Bipolar disorder (BD) is a common psychiatric disease with estimated
heritability ranging from 80%-85%. Meanwhile, BD shares several
key clinical features and familial determinants with schizophrenia (SZ) and major depressive disorder
(MDD). It is of vital importance to study the genetic basis of BD and the shared genetic factors with its highly relevant diseases.
BDgene was developed to address the genetic complexity of BD and its overlap with SZ and MDD.
By profound literature screening, BDgene integrates not only multi-type BD-related genetic factors
(e.g. SNP, CNV, gene, pathway),
but also overlapping genetic factors between BD and SZ/MDD, which presents a panoramic view of current genetic studies for BD.
Based on the literature data, in-depth analyses were conducted to help understand the data and data connections,
and to provide new hypothesis for new scientific findings.
BDgene will be updated quarterly to provide the research community an up-to-date resource.
We welcome your comments and suggestions on BDgene through our Forum or email.
New Papers ( 41 new papers were added in this update: Jan. 1, 2015 - March 31, 2016)
1. Ament, S. A., et al. (2015). "Rare variants in neuronal excitability genes influence risk for bipolar disorder." Proc Natl Acad Sci U S A 112(11): 3576-3581.
PubMed
2. Eslami Amirabadi, M. R., et al. (2015). "Monoamine oxidase a gene polymorphisms and bipolar disorder in Iranian population." Iran Red Crescent Med J 17(2): e23095.
PubMed
3. Green, E. K., et al. (2015). "Copy number variation in bipolar disorder." Mol Psychiatry.
PubMed
4. Kember, R. L., et al. (2015). "Copy number variants encompassing Mendelian disease genes in a large multigenerational family segregating bipolar disorder." BMC Genet 16: 27.
PubMed
5. Lai, Y. C., et al. (2015). "Investigation of associations between NR1D1, RORA and RORB genes and bipolar disorder." PLoS One 10(3): e0121245.
PubMed
6. Kucukali, C. I., C. Ulusoy, et al. (2015). "Evaluation of paraoxonase 1 polymorphisms in patients with bipolar disorder." In Vivo 29(1): 103-108.
PubMed
7. Mohammadi, S., et al. (2015). "The serotonin transporter (5-HTTLPR) but not serotonin receptor (5-HT2C Cys23Ser) variant is associated with bipolar I disorder in Kurdish population from Western Iran." Neurosci Lett 590: 91-95.
PubMed
8. Ni, P., et al. (2015). "Methionine sulfoxide reductase A (MsrA) associated with bipolar I disorder and executive functions in A Han Chinese population." J Affect Disord 184: 235-238.
PubMed
9. Pandolfo, G., et al. (2015). "Association of the COMT synonymous polymorphism Leu136Leu and missense variant Val158Met with mood disorders." J Affect Disord 177: 108-113.
PubMed
10. Sun, Y., et al. (2015). "Association between variants of zinc finger genes and psychiatric disorders: systematic review and meta-analysis." Schizophr Res 162(1-3): 124-137.
PubMed
11. Uemura, T., M. Green, et al. (2015). "CACNA1C SNP rs1006737 associates with bipolar I disorder independent of the Bcl-2 SNP rs956572 variant and its associated effect on intracellular calcium homeostasis." World J Biol Psychiatry: 1-10.
PubMed
12. Wang, L. J., et al. (2015). "A potential interaction between COMT and MTHFR genetic variants in Han Chinese patients with bipolar II disorder." Sci Rep 5: 8813.
PubMed
13. Zhang, C., et al. (2015). "ZNF804A Genetic Variation Confers Risk to Bipolar Disorder." Mol Neurobiol.
PubMed
14. Atakhorrami, M., et al. (2015). "A genetic variant in CAMKK2 gene is possibly associated with increased risk of bipolar disorder." J Neural Transm (Vienna).
PubMed
15. Chang, S., et al. (2015). "Pathway-based analysis for genome-wide association study data of bipolar disorder provides new insights for genetic study." Protein Cell 6(12): 912-915.
PubMed
16. Chen, X., et al. (2015). "A novel relationship for schizophrenia, bipolar and major depressive disorder Part 7: A hint from chromosome 7 high density association screen." Behav Brain Res 293: 241-251.
PubMed
17. Cho, C. H., et al. (2015). "CDH13 and HCRTR2 May Be Associated with Hypersomnia Symptom of Bipolar Depression: A Genome-Wide Functional Enrichment Pathway Analysis." Psychiatry Investig 12(3): 402-407.
PubMed
18. Forstner, A. J., et al. (2015). "Genome-wide analysis implicates microRNAs and their target genes in the development of bipolar disorder." Transl Psychiatry 5: e678.
PubMed
19. Gonzalez, R., et al. (2015). "Identification of circadian gene variants in bipolar disorder in Latino populations." J Affect Disord 186: 367-375.
PubMed
20. Hughes, T., et al. (2015). "A Loss-of-Function Variant in a Minor Isoform of ANK3 Protects Against Bipolar Disorder and Schizophrenia." Biol Psychiatry.
PubMed
21. Lekman, M., et al. (2015). "A significant risk locus on 19q13 for bipolar disorder identified using a combined genome-wide linkage and copy number variation analysis." BioData Min 8: 42.
PubMed
22. Li, M., et al. (2015). "Convergent Lines of Evidence Support LRP8 as a Susceptibility Gene for Psychosis." Mol Neurobiol.
PubMed
23. Liu, Z., et al. (2015). "MAOA Variants and Genetic Susceptibility to Major Psychiatric Disorders." Mol Neurobiol.
PubMed
24. Nassan, M., et al. (2015). "Association of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism with early-onset bipolar disorder." Bipolar Disord 17(6): 645-652.
PubMed
25. Yang, S. Y., et al. (2015). "Association between ST8SIA2 and the Risk of Schizophrenia and Bipolar I Disorder across Diagnostic Boundaries." PLoS One 10(9): e0139413.
PubMed
26. Cuellar-Barboza, A. B., et al. (2016). "Accumulating evidence for a role of TCF7L2 variants in bipolar disorder with elevated body mass index." Bipolar Disord.
PubMed
27. Drago, A., et al. (2016). "The microtubule-associated molecular pathways may be genetically disrupted in patients with Bipolar Disorder. Insights from the molecular cascades." J Affect Disord 190: 429-438.PubMed
28. Emamalizadeh, B., et al. (2016). "RIT2 Polymorphisms: Is There a Differential Association?" Mol Neurobiol.
PubMed
29. Forero, D. A., et al. (2016). "A network of synaptic genes associated with schizophrenia and bipolar disorder." Schizophr Res.
PubMed
30. Gao, J., et al. (2016). "TPH2 gene polymorphisms and bipolar disorder: A meta-analysis." Am J Med Genet B Neuropsychiatr Genet 171(2): 145-152.
PubMed
31. Khan, R. A., et al. (2016). "A new risk locus in the ZEB2 gene for schizophrenia in the Han Chinese population." Prog Neuropsychopharmacol Biol Psychiatry 66: 97-103.
PubMed
32. Liu, X., et al. (2016). "A genome-wide association study of bipolar disorder with comorbid eating disorder replicates the SOX2-OT region." J Affect Disord 189: 141-149.
PubMed
33. Soler, J., et al. (2016). "Influence of DAOA and RGS4 genes on the risk for psychotic disorders and their associated executive dysfunctions: A family-based study." Eur Psychiatry 32: 42-47.
PubMed
34. Wen, Z., et al. (2016). "Genetic association between NRG1 and schizophrenia, major depressive disorder, bipolar disorder in Han Chinese population." Am J Med Genet B Neuropsychiatr Genet 171(3): 468-478.
PubMed
35. Wen, Z., et al. (2016). "Polymorphisms in NRGN are associated with schizophrenia, major depressive disorder and bipolar disorder in the Han Chinese population." J Affect Disord 194: 180-187.
PubMed
36. Zhang, C., et al. (2016). "A comprehensive analysis of NDST3 for schizophrenia and bipolar disorder in Han Chinese." Transl Psychiatry 6: e701.
PubMed
37. Ozdemircan, A., et al. (2015). "COX-2 gene variants in bipolar disorder-I." Psychiatr Danub 27(4): 385-389.
PubMed
38. Fatjo-Vilas, M., et al. (2016). "Involvement of NRN1 gene in schizophrenia-spectrum and bipolar disorders and its impact on age at onset and cognitive functioning." World J Biol Psychiatry 17(2): 129-139.
PubMed
39. Hoeffding, L. K., et al. (2016). "Identification of rare high-risk copy number variants affecting the dopamine transporter gene in mental disorders." Nord J Psychiatry 70(4): 276-279.
PubMed
40. Kazemi-Noughabi, M., et al. (2016). "Association between insertion/deletion polymorphism in intron 3 of XRCC4 and susceptibility to type I bipolar disorder." Psychiatr Genet 26(1): 52.
PubMed
41. Khan, R. A., et al. (2016). "Analysis of association between common variants in the SLCO6A1 gene with schizophrenia, bipolar disorder and major depressive disorder in the Han Chinese population." World J Biol Psychiatry 17(2): 140-146.
PubMed
Citation: Chang, S. H., Gao, L., Li, Z., Zhang, W. N., Du, Y., & Wang, J. (2013).
BDgene: A Genetic Database for Bipolar Disorder and Its Overlap With Schizophrenia and Major
Depressive Disorder. Biol Psychiatry. doi: 10.1016/j.biopsych.2013.04.016
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