A Search Tool for Identification and Analysis of Conserved Sequence Patterns in Saccharomyces spp. Orthologous Promoters

Article type: Research Article

Authors: Kohli, Davinder K. | Srikanth, Chittur V. | Bachhawat, Anand K.

Affiliations: Institute of Microbial Technology, Sector 39-A Chandigarh - 160 036, India. Tel.: +91 172 2690908; Fax: +91 172 2690632/+91 172 2690585; E-mail: [email protected], [email protected]; URL: http://imtech.res.in/~anand

Note: [] Corresponding author

Abstract: We describe a web-based resource to identify, search and analyze sequence patterns conserved in the multiple sequence alignments of orthologous promoters from closely related/distant Saccharomyces spp. The webtool interfaces with a database where conserved sequence patterns (greater than 4 bp) have been previously extracted from genome-wide promoter alignments, allowing one to carry out user-defined genome-wide searches for conserved sequences to assist in the discovery of novel promoter elements based on comparative genomics. The web-based server can be accessed at http://www2.imtech.res.in/anand/sacch_prom_pat.html.

Keywords: Saccharomyces, orthologs, promoter, database, comparative genomics, motif

Journal: In Silico Biology, vol. 4, no. 4, pp. 411-415, 2004