@prefix dbo: <http://dbpedia.org/ontology/> . @prefix dbr: <http://dbpedia.org/resource/> . dbr:Coincidence_detection_in_neurobiology dbo:wikiPageWikiLink dbr:Long-term_depression . dbr:Computational_neurogenetic_modeling dbo:wikiPageWikiLink dbr:Long-term_depression . dbr:Metaplasticity dbo:wikiPageWikiLink dbr:Long-term_depression . dbr:Activity-dependent_plasticity dbo:wikiPageWikiLink dbr:Long-term_depression . dbr:Didactic_organisation dbo:wikiPageWikiLink dbr:Long-term_depression . dbr:Synaptic_fatigue dbo:wikiPageWikiLink dbr:Long-term_depression . dbr:Collapsin_response_mediator_protein_family dbo:wikiPageWikiLink dbr:Long-term_depression . dbr:Synaptic_weight dbo:wikiPageWikiLink dbr:Long-term_depression . dbr:Synaptic_tagging dbo:wikiPageWikiLink dbr:Long-term_depression . dbr:Nonsynaptic_plasticity dbo:wikiPageWikiLink dbr:Long-term_depression . dbr:Schaffer_collateral dbo:wikiPageWikiLink dbr:Long-term_depression . dbr:Spine_apparatus dbo:wikiPageWikiLink dbr:Long-term_depression . dbr:Long-term_potentiation dbo:wikiPageWikiLink dbr:Long-term_depression . dbr:Inferior_olivary_nucleus dbo:wikiPageWikiLink dbr:Long-term_depression . dbr:Chemical_synapse dbo:wikiPageWikiLink dbr:Long-term_depression . dbr:Memory dbo:wikiPageWikiLink dbr:Long-term_depression . @prefix foaf: <http://xmlns.com/foaf/0.1/> . @prefix wikipedia-en: <http://en.wikipedia.org/wiki/> . wikipedia-en:Long-term_depression foaf:primaryTopic dbr:Long-term_depression . dbr:LTD dbo:wikiPageWikiLink dbr:Long-term_depression ; dbo:wikiPageDisambiguates dbr:Long-term_depression . dbr:Synaptic_plasticity dbo:wikiPageWikiLink dbr:Long-term_depression . dbr:Min_Zhuo dbo:wikiPageWikiLink dbr:Long-term_depression . dbr:Ocular_dominance_column dbo:wikiPageWikiLink dbr:Long-term_depression . dbr:Dopamine_receptor_D5 dbo:wikiPageWikiLink dbr:Long-term_depression . dbr:Early_long-term_potentiation dbo:wikiPageWikiLink dbr:Long-term_depression . dbr:Spike-timing-dependent_plasticity dbo:wikiPageWikiLink dbr:Long-term_depression . dbr:BCM_theory dbo:wikiPageWikiLink dbr:Long-term_depression . dbr:Long_term_depression dbo:wikiPageWikiLink dbr:Long-term_depression ; dbo:wikiPageRedirects dbr:Long-term_depression . dbr:Ultrasensitivity dbo:wikiPageWikiLink dbr:Long-term_depression . dbr:Epigenetics_in_learning_and_memory dbo:wikiPageWikiLink dbr:Long-term_depression . dbr:Serena_Dudek dbo:wikiPageWikiLink dbr:Long-term_depression . <http://dbpedia.org/resource/Oja\u0027s_rule> dbo:wikiPageWikiLink dbr:Long-term_depression . dbr:Actin_remodeling_of_neurons dbo:wikiPageWikiLink dbr:Long-term_depression . dbr:Portrait_of_George_Dyer_Talking dbo:wikiPageWikiLink dbr:Long-term_depression . dbr:Barrel_cortex dbo:wikiPageWikiLink dbr:Long-term_depression . <http://dbpedia.org/resource/(RS)-MCPG> dbo:wikiPageWikiLink dbr:Long-term_depression . dbr:Muscle_memory dbo:wikiPageWikiLink dbr:Long-term_depression . dbr:Dopamine_hypothesis_of_schizophrenia dbo:wikiPageWikiLink dbr:Long-term_depression . dbr:Addiction-related_structural_neuroplasticity dbo:wikiPageWikiLink dbr:Long-term_depression . @prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> . @prefix owl: <http://www.w3.org/2002/07/owl#> . dbr:Long-term_depression rdf:type owl:Thing . @prefix yago: <http://dbpedia.org/class/yago/> . dbr:Long-term_depression rdf:type yago:YagoPermanentlyLocatedEntity , yago:Act100030358 , yago:WikicatMemoryProcesses , yago:Activity100407535 , dbo:Album , yago:Abstraction100002137 , yago:Procedure101023820 , yago:Event100029378 , yago:PsychologicalFeature100023100 . @prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> . dbr:Long-term_depression rdfs:label "\u062A\u062E\u0645\u064A\u062F \u0637\u0648\u064A\u0644 \u0627\u0644\u0623\u0645\u062F"@ar , "Long term depression"@it , "Long-term depression"@en , "Depresi\u00F3n a largo plazo"@es , "\uC7A5\uAE30\uC5B5\uC555"@ko , "D\u00E9pression synaptique \u00E0 long terme"@fr , "Depress\u00E3o de longa dura\u00E7\u00E3o"@pt , "\u9577\u671F\u6291\u5236\u4F5C\u7528"@zh , "Langzeit-Depression"@de , "\u0414\u043E\u0432\u0433\u043E\u0442\u0440\u0438\u0432\u0430\u043B\u0435 \u043F\u0440\u0438\u0433\u043D\u0456\u0447\u0435\u043D\u043D\u044F"@uk ; rdfs:comment "\u9577\u671F\u6291\u5236\u4F5C\u7528\uFF08\u82F1\u8A9E\uFF1ALong-term depression\uFF0CLTD\uFF09\u53C8\u7A31\u9577\u6642\u7A0B\u6291\u5236\u4F5C\u7528\u3001\u957F\u671F\u6291\u52BF\uFF0C\u6307\u795E\u7ECF\u7A81\u89E6\u6301\u7EED\u51E0\u4E2A\u5C0F\u65F6\u5230\u51E0\u5929\u7684\u6291\u5236\u884C\u4E3A\u3002\u5F3A\u70C8\u7684\u7A81\u89E6\u523A\u6FC0\uFF08\u5C0F\u8111Purkinje\u7EC6\u80DE\uFF09\u6216\u8005\u957F\u671F\u7684\u5F31\u7A81\u89E6\u523A\u6FC0\uFF08\u6D77\u9A6C\u4F53\uFF09\u5747\u53EF\u5BFC\u81F4\u957F\u671F\u6291\u52BF\u7684\u5F62\u6210\u3002\u957F\u671F\u6291\u52BF\u88AB\u8BA4\u4E3A\u662F\u540E\u7A81\u89E6\u63A5\u53D7\u4F53\u5BC6\u5EA6\u7684\u6539\u53D8\u5BFC\u81F4\u7684\uFF0C\u4F46\u662F\u524D\u7A81\u89E6\u91CA\u653E\u7269\u7684\u6539\u53D8\u4E5F\u53EF\u80FD\u6709\u4E00\u5B9A\u5F71\u54CD\u3002\u5C0F\u8111\u7684\u957F\u671F\u6291\u52BF\u88AB\u5047\u5B9A\u5BF9\u8FD0\u52A8\u795E\u7ECF\u7684\u5B66\u4E60\u5177\u6709\u91CD\u8981\u4F5C\u7528\u3002\u6D77\u9A6C\u4F53\u7684\u957F\u671F\u6291\u52BF\u4E5F\u53EF\u80FD\u5BF9\u6E05\u9664\u8FC7\u53BB\u7684\u8BB0\u5FC6\u5177\u6709\u91CD\u8981\u4F5C\u7528\u3002\u6D77\u9A6C\u4F53/\u5927\u8111\u76AE\u5C42\u957F\u671F\u6291\u52BF\u53EF\u7531NMDA\u63A5\u53D7\u4F53\uFF0C\u4EE3\u8B1D\u578B\u9EA9\u80FA\u9178\u9E7D\u53D7\u9AD4\uFF08mGluR\uFF09\u6216\u8005endocannabinoids\u63A7\u5236\u3002"@zh , "Unter Langzeit-Depression (eng: long-term depression, LTD) versteht man eine dauerhafte Abschw\u00E4chung der Signal\u00FCbertragung an den Synapsen von Nervenzellen. Zusammen mit ihrem Gegenst\u00FCck \u2013 der Langzeit-Potenzierung (LTP) stellt LTD eine der zellul\u00E4ren Grundlagen von Lernen und Ged\u00E4chtnis dar. Es wird heute gemeinhin angenommen, dass durch diese Formen von synaptischer Plastizit\u00E4t Informationen in Nervensystemen dauerhaft abgespeichert werden. Zwar ist es bislang noch nicht gelungen, Lernen direkt auf LTP und LTD zur\u00FCckzuf\u00FChren, es gibt aber eine Reihe indirekter Hinweise darauf, dass sie den zellul\u00E4ren Mechanismus bestimmter Lernformen darstellen."@de , "\u0414\u043E\u0432\u0433\u043E\u0442\u0440\u0438\u0432\u0430\u043B\u0435 \u043F\u0440\u0438\u0433\u043D\u0456\u0447\u0435\u043D\u043D\u044F, \u0430\u0431\u043E \u0434\u043E\u0432\u0433\u043E\u0442\u0440\u0438\u0432\u0430\u043B\u0435 \u0441\u0438\u043D\u0430\u043F\u0442\u0438\u0447\u043D\u0435 \u043F\u0440\u0438\u0433\u043D\u0456\u0447\u0435\u043D\u043D\u044F (Long-Term Depression, LTD) - \u0432 \u043D\u0435\u0439\u0440\u043E\u0444\u0456\u0437\u0456\u043E\u043B\u043E\u0433\u0456\u0457 \u0437\u0430\u043B\u0435\u0436\u043D\u0430 \u0432\u0456\u0434 \u0430\u043A\u0442\u0438\u0432\u043D\u043E\u0441\u0442\u0456 \u043D\u0435\u0439\u0440\u043E\u043D\u043D\u0438\u0445 \u0441\u0438\u0433\u043D\u0430\u043B\u0456\u0432 \u0432\u0442\u0440\u0430\u0442\u0430 \u0435\u0444\u0435\u043A\u0442\u0438\u0432\u043D\u043E\u0441\u0442\u0456 \u0440\u043E\u0431\u043E\u0442\u0438 \u0441\u0438\u043D\u0430\u043F\u0441\u0456\u0432, \u0449\u043E \u043C\u043E\u0436\u0435 \u0442\u0440\u0438\u0432\u0430\u0442\u0438 \u0432\u0456\u0434 \u043A\u0456\u043B\u044C\u043A\u043E\u0445 \u0434\u0435\u0441\u044F\u0442\u043A\u0456\u0432 \u0445\u0432\u0438\u043B\u0438\u043D \u0434\u043E \u043A\u0456\u043B\u044C\u043A\u043E\u0445 \u0434\u0456\u0431. \u0412 \u0446\u0435\u043D\u0442\u0440\u0430\u043B\u044C\u043D\u0456\u0439 \u043D\u0435\u0440\u0432\u043E\u0432\u0456\u0439 \u0441\u0438\u0441\u0442\u0435\u043C\u0456, \u0437\u0430\u043B\u0435\u0436\u043D\u043E \u0432\u0456\u0434 \u0440\u0435\u0433\u0456\u043E\u043D\u0430 \u043C\u043E\u0437\u043A\u0443 \u0442\u0430 \u0441\u0442\u0430\u0434\u0456\u0457 \u0439\u043E\u0433\u043E \u0440\u043E\u0437\u0432\u0438\u0442\u043A\u0443, LTD \u043C\u043E\u0436\u0435 \u0431\u0443\u0442\u0438 \u0432\u0438\u043A\u043B\u0438\u043A\u0430\u043D\u0430 \u0440\u0456\u0437\u043D\u0438\u043C\u0438 \u043C\u0435\u0445\u0430\u043D\u0456\u0437\u043C\u0430\u043C\u0438. \u041D\u0430\u0439\u043A\u0440\u0430\u0449\u0435 \u0432\u0438\u0432\u0447\u0435\u043D\u0438\u043C\u0438 \u0454 \u043C\u0435\u0445\u0430\u043D\u0456\u0437\u043C\u0438 LTD \u0432 \u0433\u0456\u043F\u043E\u043A\u0430\u043C\u043F\u0456 \u0442\u0430 \u043C\u043E\u0437\u043E\u0447\u043A\u0443. \u0412 \u0433\u0456\u043F\u043E\u043A\u0430\u043C\u043F\u0456 LTD \u0432\u0438\u043A\u043B\u0438\u043A\u0430\u0454 \u0441\u043B\u0430\u0431\u043A\u0430, \u0430\u043B\u0435 \u0434\u043E\u0432\u0433\u043E\u0442\u0440\u0438\u0432\u0430\u043B\u0430 \u0441\u0442\u0438\u043C\u0443\u043B\u044F\u0446\u0456\u044F \u043D\u0435\u0439\u0440\u043E\u043D\u0456\u0432; \u043D\u0430\u0442\u043E\u043C\u0456\u0441\u0442\u044C \u0432 \u043C\u043E\u0437\u043E\u0447\u043A\u0443 \u0434\u043B\u044F \u0432\u0438\u043A\u043B\u0438\u043A\u0430\u043D\u043D\u044F LTD \u0441\u0442\u0438\u043C\u0443\u043B\u044F\u0446\u0456\u044F \u043C\u0430\u0454 \u0431\u0443\u0442\u0438 \u043D\u0430\u0431\u0430\u0433\u0430\u0442\u043E \u0441\u0438\u043B\u044C\u043D\u0456\u0448\u043E\u044E (\u044F\u043A \u043F\u043E\u043A\u0430\u0437\u0430\u043D\u043E \u043D\u0430 ). \u041E\u0441\u043D\u043E\u0432\u043D\u0438\u043C\u0438 \u043C\u0435\u0445\u0430\u043D\u0456\u0437\u043C\u0430\u043C\u0438 LTD \u0432\u0432\u0430\u0436\u0430\u044E\u0442\u044C\u0441\u044F \u0437\u043D\u0438\u0436\u0435\u043D\u043D\u044F \u043A\u0456\u043B\u044C\u043A\u043E\u0441\u0442\u0456 \u0440\u0435\u0446\u0435\u043F\u0442\u043E\u0440\u0456\u0432 \u043D\u0430 \u043F\u043E\u0441\u0442\u0441\u0438\u043D\u0430\u043F\u0442\u0438\u0447\u043D\u0456\u0439 \u043C\u0435\u043C\u0431\u0440\u0430\u043D\u0456, \u0430 \u0442\u0430\u043A\u043E\u0436 \u0437\u043D\u0438\u0436\u0435\u043D\u043D\u044F \u0435\u0444\u0435\u043A\u0442\u0438\u0432\u043D\u043E\u0441\u0442\u0456 \u0432\u0438\u0432\u0456\u043B\u044C\u043D\u0435\u043D\u043D\u044F \u043D\u0435\u0439\u0440\u043E\u043C\u0435\u0434\u0456\u0430\u0442\u043E\u0440\u0430 \u0437 \u043F\u0440\u0435\u0441\u0438\u043D\u0430\u043F\u0442\u0438\u0447\u043D\u043E\u0433\u043E \u0431\u0443\u0442\u043E\u043D\u0430. LTD \u0432 \u043C\u043E\u0437\u043E\u0447\u043A\u0443"@uk , "In neurophysiology, long-term depression (LTD) is an activity-dependent reduction in the efficacy of neuronal synapses lasting hours or longer following a long patterned stimulus. LTD occurs in many areas of the CNS with varying mechanisms depending upon brain region and developmental progress."@en , "\uC7A5\uAE30\uC5B5\uC555(\u9577\u671F\u6291\u58D3, LTD: Long-term depression)\uC740 \uC2E0\uACBD\uACFC\uD559 \uBD84\uC57C\uC5D0\uC11C \uBA87 \uC2DC\uAC04 \uD639\uC740 \uADF8 \uC774\uC0C1 \uC9C0\uC18D\uB418\uB294 \uD615\uC2DD\uC801 \uC790\uADF9\uC5D0 \uB300\uD574 \uC2E0\uACBD\uC138\uD3EC \uC2DC\uB0C5\uC2A4\uC758 \uD65C\uC131 \uD6A8\uC728\uC774 \uAC10\uC18C\uD558\uB294 \uAC83\uC744 \uB9D0\uD55C\uB2E4.\uC7A5\uAE30 \uC5B5\uC81C\uB294 \uB1CC \uC601\uC5ED\uACFC \uBC1C\uB2EC \uACFC\uC815\uC5D0 \uB530\uB77C \uB2E4\uC591\uD55C \uAE30\uC791\uC744 \uD1B5\uD574 \uC5EC\uB7EC \uC911\uCD94\uC2E0\uACBD\uACC4\uC5D0\uC11C \uB098\uD0C0\uB09C\uB2E4. \uD574\uB9C8\uC640 \uC18C\uB1CC\uC5D0\uC11C\uC758 \uC7A5\uAE30\uC5B5\uC81C\uAC00 \uAC00\uC7A5 \uC798 \uBD84\uC11D \uB418\uC5C8\uC73C\uBA70, \uB2E4\uB978 \uB1CC \uC601\uC5ED\uC5D0\uC11C\uC758 \uC7A5\uAE30\uC5B5\uC81C \uAE30\uC791\uB3C4 \uC774\uD574\uB418\uC5C8\uB2E4. \uC7A5\uAE30 \uC5B5\uC81C\uB294 \uB2E4\uC591\uD55C \uC2E0\uACBD\uC804\uB2EC\uBB3C\uC9C8\uC744 \uBD84\uBE44\uD558\uB294 \uC5EC\uB7EC \uC885\uB958\uC758 \uC2E0\uACBD\uC138\uD3EC\uC5D0\uC11C \uB098\uD0C0\uB098\uB294 \uAC83\uC774 \uBC1C\uACAC\uB418\uC5C8\uC73C\uB098, \uC7A5\uAE30\uC5B5\uC81C\uC5D0 \uAD00\uC5EC\uD558\uB294 \uC77C\uBC18\uC801\uC778 \uC2E0\uACBD \uC804\uB2EC\uBB3C\uC9C8\uC740 \uC8FC\uB85C L-\uAE00\uB8E8\uD0D0\uC0B0\uC774\uB2E4. L-\uAE00\uB8E8\uD0D0\uC0B0\uC740 \uC7A5\uAE30 \uC5B5\uC81C\uAC00 \uC77C\uC5B4\uB098\uB294 \uB3D9\uC548 NMDA \uAE00\uB8E8\uD0D0\uC0B0 \uC218\uC6A9\uCCB4(N-methyl-D-asparate receptors), AMPA \uAE00\uB8E8\uD0D0\uC0B0 \uC218\uC6A9\uCCB4(\u03B1-amino-3-hydroxy-5-methylisoxazole-4-propionicacid receptor), kinate \uC218\uC6A9\uCCB4, \uB300\uC0AC\uD615 \uAE00\uB8E8\uD0D0\uC0B0 \uC218\uC6A9\uCCB4(mGluR)\uC5D0 \uC791\uC6A9\uD55C\uB2E4. \uC774\uB7EC\uD55C \uC7A5\uAE30 \uC5B5\uC81C\uB294 \uAC15\uB825\uD55C \uC2DC\uB0C5\uC2A4 \uC790\uADF9(\uC18C\uB1CC \uD37C\uD0A8\uC81C \uC138\uD3EC\uC5D0\uC11C \uC77C\uC5B4\uB098\uB294 \uAC83\uACFC \uAC19\uC774)\uC774\uB098 \uC57D\uD55C \uC9C0\uC18D\uC801\uC778 \uC2DC\uB0C5\uC2A4 \uC790\uADF9\uC5D0 \uC758\uD574 \uB098\uD0C0\uB09C\uB2E4(\uD574\uB9C8\uC5D0\uC11C\uC640 \uAC19\uC774). \uC7A5\uAE30 \uAC15\uD654(Long-term potentiation, LTP)\uB294 \uC7A5\uAE30 \uC5B5\uC81C\uC5D0 \uBC18\uB300\uB418\uB294 \uAE30\uC791 \uC774\uB2E4; \uC774\uAC83\uC740 \uC624\uB798 \uC9C0\uC18D\uB418\uB294 \uC2DC\uB0C5\uC2A4 \uAC15\uB3C4\uC758 \uC99D\uAC00\uC774\uB2E4. \uC7A5\uAE30 \uC5B5\uC81C\uC640 \uC7A5\uAE30 \uAC15\uD654\uB294 \uC2E0\uACBD\uC138\uD3EC\uC758 \uC2DC\uB0C5\uC2A4 \uAC00\uC18C\uC131\uC5D0 \uD568\uAED8 \uC601\uD5A5\uC744 \uBBF8\uCE58\uB294 \uC694\uC18C\uC774\uB2E4. \uC7A5\uAE30 \uC5B5\uC81C\uB294 \uC8FC\uB85C \uC2DC\uB0C5\uC2A4 \uD6C4 \uC2E0\uACBD\uC138\uD3EC\uC758 \uC218\uC6A9\uCCB4 \uC218\uAC00 \uAC10\uC18C\uD558\uC5EC \uB098\uD0C0\uB098\uB294 \uAC83\uC73C\uB85C \uC0DD\uAC01\uB418\uBA70, \uC2DC\uB0C5\uC2A4 \uC804 \uC2E0\uACBD\uC138\uD3EC\uC758 \uC2E0\uACBD\uC804\uB2EC\uBB3C\uC9C8 \uBD84\uBE44\uC758 \uAC10\uC18C \uB610\uD55C \uC601\uD5A5\uC744 \uBBF8\uCE5C\uB2E4. \uC18C\uB1CC\uC758 \uC7A5\uAE30 \uC5B5\uC81C\uB294 "@ko , "La depresi\u00F3n a largo plazo (DLP)\u200B en neurofisiolog\u00EDa, es un tipo de plasticidad neuronal en el que se hay una reducci\u00F3n de la eficacia de la sinapsis neuronal. La expresi\u00F3n de DLP depende de la actividad de las neuronas que conforman la sinapsis. La DLP dura horas o m\u00E1s."@es , "La Long-Term Depression (LTD, o \"depressione a lungo termine\") \u00E8 un fenomeno fisiologico opposto alla Long-Term Potentiation (LTP, o \"potenziamento a lungo termine\") e, come questo, rappresenta un tipo di plasticit\u00E0 sinaptica, e uno dei meccanismi cellulari e molecolari ritenuti alla base di processi di apprendimento di nuove memorie. \u00C8 stata studiata in particolare, ad esempio, nell'ippocampo e nel cervelletto (nelle sinapsi tra le e le Cellule di Purkinje)."@it , "La d\u00E9pression \u00E0 long terme (DLT) est \u00AB une r\u00E9duction durable de l'efficacit\u00E9 de la transmission synaptique qui fait suite \u00E0 certains types de stimulation \u00BB."@fr , "Em neurofisiologia, a depress\u00E3o de longa dura\u00E7\u00E3o (LTD) \u00E9 uma redu\u00E7\u00E3o dependente de atividade das sinapses neuronais que dura por horas, ou at\u00E9 mais, seguindo um est\u00EDmulo longo padronizado. A LTD ocorre em v\u00E1rias \u00E1reas do SNC com mecanismos variados dependendo da regi\u00E3o do enc\u00E9falo e no progresso do desenvolvimento. A LTD foi caracterizada principalmente no hipocampo e no cerebelo, por\u00E9m h\u00E1 outras \u00E1reas nas quais os mecanismos de LTD s\u00E3o compreendidos tamb\u00E9m. A LTD j\u00E1 foi encontrada em diferentes tipos de neur\u00F4nios, contudo, o neurotransmissor envolvido a maior parte das vezes na LTD \u00E9 o L-glutamato.O glutamato age em receptores N-metil-D- aspartato (NMDA), em receptores \u03B1-amino-3-hidr\u00F3xi-5-metilisoxazole-4-propionato (AMPA), receptores kainato (KA) e receptores metabotr\u00F3picos(mGluRs) duran"@pt , "\u0641\u064A \u0627\u0644\u0641\u0633\u064A\u0648\u0644\u0648\u062C\u064A\u0627 \u0627\u0644\u0639\u0635\u0628\u064A\u0629\u060C \u064A\u064F\u0639\u0631\u0641 \u0627\u0644\u062A\u062E\u0645\u064A\u062F \u0637\u0648\u064A\u0644 \u0627\u0644\u0623\u0645\u062F \u0628\u0623\u0646\u0647 \u0627\u0646\u062E\u0641\u0627\u0636 \u0645\u0639\u062A\u0645\u062F \u0639\u0644\u0649 \u0627\u0644\u0646\u0634\u0627\u0637 \u0641\u064A \u0641\u0639\u0627\u0644\u064A\u0629 \u0627\u0644\u0645\u0634\u0627\u0628\u0643 \u0627\u0644\u0639\u0635\u0628\u064A\u0629\u060C \u064A\u0633\u062A\u0645\u0631 \u0644\u0633\u0627\u0639\u0627\u062A \u0623\u0648 \u0623\u0643\u062B\u0631 \u0628\u0639\u062F \u0627\u0644\u062A\u0646\u0628\u064A\u0647 \u0637\u0648\u064A\u0644 \u0627\u0644\u0646\u0645\u0637. \u064A\u062D\u062F\u062B \u0627\u0644\u062A\u062E\u0645\u064A\u062F \u0637\u0648\u064A\u0644 \u0627\u0644\u0623\u0645\u062F \u0641\u064A \u0627\u0644\u0639\u062F\u064A\u062F \u0645\u0646 \u0645\u0646\u0627\u0637\u0642 \u0627\u0644\u062C\u0647\u0627\u0632 \u0627\u0644\u0639\u0635\u0628\u064A \u0627\u0644\u0645\u0631\u0643\u0632\u064A \u0628\u0622\u0644\u064A\u0627\u062A \u0645\u062E\u062A\u0644\u0641\u0629 \u0627\u0639\u062A\u0645\u0627\u062F\u064B\u0627 \u0639\u0644\u0649 \u0645\u0646\u0637\u0642\u0629 \u0627\u0644\u062F\u0645\u0627\u063A \u0648\u0627\u0644\u0645\u0633\u0627\u0631 \u0627\u0644\u0646\u0645\u0627\u0626\u064A."@ar ; foaf:depiction <http://commons.wikimedia.org/wiki/Special:FilePath/Bi-directional_modulation_of_AMPA_receptor.png> . @prefix dcterms: <http://purl.org/dc/terms/> . @prefix dbc: <http://dbpedia.org/resource/Category:> . dbr:Long-term_depression dcterms:subject dbc:Neuroplasticity , dbc:Memory , dbc:Neurophysiology ; dbo:abstract "La depresi\u00F3n a largo plazo (DLP)\u200B en neurofisiolog\u00EDa, es un tipo de plasticidad neuronal en el que se hay una reducci\u00F3n de la eficacia de la sinapsis neuronal. La expresi\u00F3n de DLP depende de la actividad de las neuronas que conforman la sinapsis. La DLP dura horas o m\u00E1s. La DLP tiene lugar en diversas \u00E1reas del sistema nervioso central con diferentes mecanismos dependiendo del \u00E1rea del cerebro y del periodo del desarrollo del mismo. Por ejemplo, la DLP en el hipocampo y el cerebelo son las que m\u00E1s se han estudiado, pero tambi\u00E9n existen otras \u00E1reas del cerebro en las cuales la DLP existe.\u200B Se ha comprobado que la DLP ocurre en diferentes tipos de neuronas que liberan varios neurotransmisores, excitatorios o inhibitorios. Puede resultar de est\u00EDmulos sin\u00E1pticos fuertes, como ocurre en c\u00E9lulas de Purkinje del cerebelo, o de est\u00EDmulos sin\u00E1pticos d\u00E9biles pero persistentes como ocurre en el hipocampo. Se estima que la DLP resulta del decremento en la densidad de receptores postsin\u00E1pticos,\u200B aunque tambi\u00E9n puede ser influenciada por decrecimiento en la liberaci\u00F3n de neurotransmisores.\u200B Tradicionalmente, la DLP en el cerebelo se ha asociado con el aprendizaje motriz en la corteza, sin embargo, recientes experimentos no apoyan esta hip\u00F3tesis.\u200B En cambio en el hipocampo, la DLP puede ser importante para deshacerse de trazos de memorias viejas.\u200B\u200B La DLP es uno de los diferentes procesos que sirve para debilitar de manera selectiva sinapsis espec\u00EDficos de manera que se pueda hacer uso constructivo de la fortaleza de la sinapsis causada por la PLP. Esto es necesario porque, si se contin\u00FAa incrementando en fuerza, la sinapsis llegar\u00EDa a su m\u00E1ximo nivel de eficacia, que en consecuencia inhibir\u00EDa procesamiento de informaci\u00F3n nueva.\u200B"@es , "\u0641\u064A \u0627\u0644\u0641\u0633\u064A\u0648\u0644\u0648\u062C\u064A\u0627 \u0627\u0644\u0639\u0635\u0628\u064A\u0629\u060C \u064A\u064F\u0639\u0631\u0641 \u0627\u0644\u062A\u062E\u0645\u064A\u062F \u0637\u0648\u064A\u0644 \u0627\u0644\u0623\u0645\u062F \u0628\u0623\u0646\u0647 \u0627\u0646\u062E\u0641\u0627\u0636 \u0645\u0639\u062A\u0645\u062F \u0639\u0644\u0649 \u0627\u0644\u0646\u0634\u0627\u0637 \u0641\u064A \u0641\u0639\u0627\u0644\u064A\u0629 \u0627\u0644\u0645\u0634\u0627\u0628\u0643 \u0627\u0644\u0639\u0635\u0628\u064A\u0629\u060C \u064A\u0633\u062A\u0645\u0631 \u0644\u0633\u0627\u0639\u0627\u062A \u0623\u0648 \u0623\u0643\u062B\u0631 \u0628\u0639\u062F \u0627\u0644\u062A\u0646\u0628\u064A\u0647 \u0637\u0648\u064A\u0644 \u0627\u0644\u0646\u0645\u0637. \u064A\u062D\u062F\u062B \u0627\u0644\u062A\u062E\u0645\u064A\u062F \u0637\u0648\u064A\u0644 \u0627\u0644\u0623\u0645\u062F \u0641\u064A \u0627\u0644\u0639\u062F\u064A\u062F \u0645\u0646 \u0645\u0646\u0627\u0637\u0642 \u0627\u0644\u062C\u0647\u0627\u0632 \u0627\u0644\u0639\u0635\u0628\u064A \u0627\u0644\u0645\u0631\u0643\u0632\u064A \u0628\u0622\u0644\u064A\u0627\u062A \u0645\u062E\u062A\u0644\u0641\u0629 \u0627\u0639\u062A\u0645\u0627\u062F\u064B\u0627 \u0639\u0644\u0649 \u0645\u0646\u0637\u0642\u0629 \u0627\u0644\u062F\u0645\u0627\u063A \u0648\u0627\u0644\u0645\u0633\u0627\u0631 \u0627\u0644\u0646\u0645\u0627\u0626\u064A. \u064A\u0639\u062F \u0627\u0644\u0639\u0645\u0644\u064A\u0629 \u0627\u0644\u0645\u0639\u0627\u0643\u0633\u0629 \u0644\u0644\u062A\u0623\u064A\u064A\u062F \u0637\u0648\u064A\u0644 \u0627\u0644\u0623\u0645\u062F\u060C \u0641\u0647\u0648 \u0623\u062D\u062F \u0627\u0644\u0639\u0645\u0644\u064A\u0627\u062A \u0627\u0644\u062A\u064A \u062A\u0636\u0639\u0641 \u0627\u0644\u0645\u0634\u0627\u0628\u0643 \u0627\u0644\u0639\u0635\u0628\u064A\u0629 \u0628\u0634\u0643\u0644 \u0627\u0646\u062A\u0642\u0627\u0626\u064A \u0645\u0646 \u0623\u062C\u0644 \u0627\u0644\u0627\u0633\u062A\u0641\u0627\u062F\u0629 \u0627\u0644\u0628\u0646\u0627\u0621\u0629 \u0645\u0646 \u0627\u0644\u062A\u0642\u0648\u064A\u0629 \u0627\u0644\u0645\u0634\u0628\u0643\u064A\u0629 \u0627\u0644\u0646\u0627\u062A\u062C\u0629 \u0639\u0646 \u0627\u0644\u062A\u0623\u064A\u064A\u062F \u0637\u0648\u064A\u0644 \u0627\u0644\u0623\u0645\u062F. \u0647\u0630\u0627 \u0636\u0631\u0648\u0631\u064A \u0644\u0623\u0646\u0647\u060C \u0625\u0630\u0627 \u0627\u0633\u062A\u0645\u0631\u062A \u0627\u0644\u0642\u0648\u0629 \u0628\u0627\u0644\u0632\u064A\u0627\u062F\u0629\u060C \u0633\u062A\u0635\u0644 \u0627\u0644\u0645\u0634\u0627\u0628\u0643 \u0627\u0644\u0639\u0635\u0628\u064A\u0629 \u0641\u064A \u0627\u0644\u0646\u0647\u0627\u064A\u0629 \u0625\u0644\u0649 \u0623\u0639\u0644\u0649 \u0645\u0633\u062A\u0648\u0649 \u0645\u0646 \u0627\u0644\u0643\u0641\u0627\u0621\u0629\u060C \u0645\u0627 \u0633\u064A\u0645\u0646\u0639 \u062A\u0631\u0645\u064A\u0632 \u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062A \u0627\u0644\u062C\u062F\u064A\u062F\u0629. \u064A\u0639\u062A\u0628\u0631 \u0643\u0644 \u0645\u0646 \u0627\u0644\u062A\u062E\u0645\u064A\u062F \u0637\u0648\u064A\u0644 \u0627\u0644\u0623\u0645\u062F \u0648\u0627\u0644\u062A\u0623\u064A\u064A\u062F \u0637\u0648\u064A\u0644 \u0627\u0644\u0623\u0645\u062F \u0645\u0646 \u0623\u0634\u0643\u0627\u0644 \u0627\u0644\u0644\u062F\u0648\u0646\u0629 \u0627\u0644\u0645\u0634\u0628\u0643\u064A\u0629."@ar , "La d\u00E9pression \u00E0 long terme (DLT) est \u00AB une r\u00E9duction durable de l'efficacit\u00E9 de la transmission synaptique qui fait suite \u00E0 certains types de stimulation \u00BB."@fr , "La Long-Term Depression (LTD, o \"depressione a lungo termine\") \u00E8 un fenomeno fisiologico opposto alla Long-Term Potentiation (LTP, o \"potenziamento a lungo termine\") e, come questo, rappresenta un tipo di plasticit\u00E0 sinaptica, e uno dei meccanismi cellulari e molecolari ritenuti alla base di processi di apprendimento di nuove memorie. \u00C8 stata studiata in particolare, ad esempio, nell'ippocampo e nel cervelletto (nelle sinapsi tra le e le Cellule di Purkinje)."@it , "In neurophysiology, long-term depression (LTD) is an activity-dependent reduction in the efficacy of neuronal synapses lasting hours or longer following a long patterned stimulus. LTD occurs in many areas of the CNS with varying mechanisms depending upon brain region and developmental progress. As the opposing process to long-term potentiation (LTP), LTD is one of several processes that serves to selectively weaken specific synapses in order to make constructive use of synaptic strengthening caused by LTP. This is necessary because, if allowed to continue increasing in strength, synapses would ultimately reach a ceiling level of efficiency, which would inhibit the encoding of new information. Both LTD and LTP are forms of synaptic plasticity."@en , "\uC7A5\uAE30\uC5B5\uC555(\u9577\u671F\u6291\u58D3, LTD: Long-term depression)\uC740 \uC2E0\uACBD\uACFC\uD559 \uBD84\uC57C\uC5D0\uC11C \uBA87 \uC2DC\uAC04 \uD639\uC740 \uADF8 \uC774\uC0C1 \uC9C0\uC18D\uB418\uB294 \uD615\uC2DD\uC801 \uC790\uADF9\uC5D0 \uB300\uD574 \uC2E0\uACBD\uC138\uD3EC \uC2DC\uB0C5\uC2A4\uC758 \uD65C\uC131 \uD6A8\uC728\uC774 \uAC10\uC18C\uD558\uB294 \uAC83\uC744 \uB9D0\uD55C\uB2E4.\uC7A5\uAE30 \uC5B5\uC81C\uB294 \uB1CC \uC601\uC5ED\uACFC \uBC1C\uB2EC \uACFC\uC815\uC5D0 \uB530\uB77C \uB2E4\uC591\uD55C \uAE30\uC791\uC744 \uD1B5\uD574 \uC5EC\uB7EC \uC911\uCD94\uC2E0\uACBD\uACC4\uC5D0\uC11C \uB098\uD0C0\uB09C\uB2E4. \uD574\uB9C8\uC640 \uC18C\uB1CC\uC5D0\uC11C\uC758 \uC7A5\uAE30\uC5B5\uC81C\uAC00 \uAC00\uC7A5 \uC798 \uBD84\uC11D \uB418\uC5C8\uC73C\uBA70, \uB2E4\uB978 \uB1CC \uC601\uC5ED\uC5D0\uC11C\uC758 \uC7A5\uAE30\uC5B5\uC81C \uAE30\uC791\uB3C4 \uC774\uD574\uB418\uC5C8\uB2E4. \uC7A5\uAE30 \uC5B5\uC81C\uB294 \uB2E4\uC591\uD55C \uC2E0\uACBD\uC804\uB2EC\uBB3C\uC9C8\uC744 \uBD84\uBE44\uD558\uB294 \uC5EC\uB7EC \uC885\uB958\uC758 \uC2E0\uACBD\uC138\uD3EC\uC5D0\uC11C \uB098\uD0C0\uB098\uB294 \uAC83\uC774 \uBC1C\uACAC\uB418\uC5C8\uC73C\uB098, \uC7A5\uAE30\uC5B5\uC81C\uC5D0 \uAD00\uC5EC\uD558\uB294 \uC77C\uBC18\uC801\uC778 \uC2E0\uACBD \uC804\uB2EC\uBB3C\uC9C8\uC740 \uC8FC\uB85C L-\uAE00\uB8E8\uD0D0\uC0B0\uC774\uB2E4. L-\uAE00\uB8E8\uD0D0\uC0B0\uC740 \uC7A5\uAE30 \uC5B5\uC81C\uAC00 \uC77C\uC5B4\uB098\uB294 \uB3D9\uC548 NMDA \uAE00\uB8E8\uD0D0\uC0B0 \uC218\uC6A9\uCCB4(N-methyl-D-asparate receptors), AMPA \uAE00\uB8E8\uD0D0\uC0B0 \uC218\uC6A9\uCCB4(\u03B1-amino-3-hydroxy-5-methylisoxazole-4-propionicacid receptor), kinate \uC218\uC6A9\uCCB4, \uB300\uC0AC\uD615 \uAE00\uB8E8\uD0D0\uC0B0 \uC218\uC6A9\uCCB4(mGluR)\uC5D0 \uC791\uC6A9\uD55C\uB2E4. \uC774\uB7EC\uD55C \uC7A5\uAE30 \uC5B5\uC81C\uB294 \uAC15\uB825\uD55C \uC2DC\uB0C5\uC2A4 \uC790\uADF9(\uC18C\uB1CC \uD37C\uD0A8\uC81C \uC138\uD3EC\uC5D0\uC11C \uC77C\uC5B4\uB098\uB294 \uAC83\uACFC \uAC19\uC774)\uC774\uB098 \uC57D\uD55C \uC9C0\uC18D\uC801\uC778 \uC2DC\uB0C5\uC2A4 \uC790\uADF9\uC5D0 \uC758\uD574 \uB098\uD0C0\uB09C\uB2E4(\uD574\uB9C8\uC5D0\uC11C\uC640 \uAC19\uC774). \uC7A5\uAE30 \uAC15\uD654(Long-term potentiation, LTP)\uB294 \uC7A5\uAE30 \uC5B5\uC81C\uC5D0 \uBC18\uB300\uB418\uB294 \uAE30\uC791 \uC774\uB2E4; \uC774\uAC83\uC740 \uC624\uB798 \uC9C0\uC18D\uB418\uB294 \uC2DC\uB0C5\uC2A4 \uAC15\uB3C4\uC758 \uC99D\uAC00\uC774\uB2E4. \uC7A5\uAE30 \uC5B5\uC81C\uC640 \uC7A5\uAE30 \uAC15\uD654\uB294 \uC2E0\uACBD\uC138\uD3EC\uC758 \uC2DC\uB0C5\uC2A4 \uAC00\uC18C\uC131\uC5D0 \uD568\uAED8 \uC601\uD5A5\uC744 \uBBF8\uCE58\uB294 \uC694\uC18C\uC774\uB2E4. \uC7A5\uAE30 \uC5B5\uC81C\uB294 \uC8FC\uB85C \uC2DC\uB0C5\uC2A4 \uD6C4 \uC2E0\uACBD\uC138\uD3EC\uC758 \uC218\uC6A9\uCCB4 \uC218\uAC00 \uAC10\uC18C\uD558\uC5EC \uB098\uD0C0\uB098\uB294 \uAC83\uC73C\uB85C \uC0DD\uAC01\uB418\uBA70, \uC2DC\uB0C5\uC2A4 \uC804 \uC2E0\uACBD\uC138\uD3EC\uC758 \uC2E0\uACBD\uC804\uB2EC\uBB3C\uC9C8 \uBD84\uBE44\uC758 \uAC10\uC18C \uB610\uD55C \uC601\uD5A5\uC744 \uBBF8\uCE5C\uB2E4. \uC18C\uB1CC\uC758 \uC7A5\uAE30 \uC5B5\uC81C\uB294 \uC6B4\uB3D9 \uD559\uC2B5\uC5D0 \uC911\uC694\uD55C \uC5ED\uD560\uC744 \uD560 \uAC83\uC73C\uB85C \uC0DD\uAC01\uB41C\uB2E4. \uD574\uB9C8\uC758 \uC7A5\uAE30\uC5B5\uC81C\uB294 \uC624\uB798\uB41C \uAE30\uC5B5\uC744 \uC5C6\uC560\uB294 \uB370\uC5D0 \uC911\uC694\uD55C \uC5ED\uD560\uC744 \uD558\uB294 \uAC83\uC73C\uB85C \uC0DD\uAC01\uB41C\uB2E4. \uD574\uB9C8\uB098 \uB300\uB1CC \uD53C\uC9C8\uC5D0\uC11C\uC758 \uC7A5\uAE30 \uC5B5\uC81C\uB294 NMDA \uAE00\uB8E8\uD0D0\uC0B0 \uC218\uC6A9\uCCB4, \uB300\uC0AC\uD615 \uAE00\uB8E8\uD0D0\uC0B0 \uC218\uC6A9\uCCB4, endocannabinoid\uC5D0 \uC758\uC874\uD558\uC5EC \uB098\uD0C0\uB09C\uB2E4. \uC7A5\uAE30 \uC5B5\uC81C\uC5D0 \uAE30\uC800 \uD558\uB294 \uBD84\uC790\uC801 \uAE30\uC791\uC5D0 \uC758\uD574 AMPA \uAE00\uB8E8\uD0D0\uC0B0 \uC218\uC6A9\uCCB4\uB294 \uC778\uC0B0\uD654 \uB418\uAC70\uB098 PF-PC \uC2DC\uB0C5\uC2A4 \uD45C\uBA74\uC5D0\uC11C \uC81C\uAC70\uB41C\uB2E4.\uC7A5\uAE30 \uC5B5\uC81C\uB294 \uC7A5\uAE30 \uAC15\uD654\uC5D0 \uC758\uD55C \uC2DC\uB0C5\uC2A4 \uAC15\uD654\uB97C \uAD6C\uC870\uC801\uC73C\uB85C \uC0AC\uC6A9\uD560 \uC218 \uC788\uAC8C\uB054 \uD558\uB294 \uD2B9\uC815 \uC2DC\uB0C5\uC2A4\uC758 \uC120\uD0DD\uC801 \uC57D\uD654\uB97C \uC720\uB3C4\uD558\uB294 \uC5EC\uB7EC \uAE30\uC791\uC911\uC758 \uD558\uB098\uC774\uB2E4. \uC2DC\uB0C5\uC2A4\uC758 \uAC15\uD654\uAC00 \uC9C0\uC18D\uC801\uC73C\uB85C \uC77C\uC5B4\uB0A0 \uACBD\uC6B0 \uC2DC\uB0C5\uC2A4\uB294 \uADF8 \uD6A8\uC728\uC758 \uCD5C\uACE0\uC810\uC5D0 \uB2EC\uD558\uAC8C \uB418\uC5B4 \uC0C8\uB85C\uC6B4 \uC815\uBCF4\uC758 \uC800\uC7A5\uC774 \uC800\uD574 \uB420 \uC218 \uC788\uC73C\uBBC0\uB85C \uC7A5\uAE30\uC5B5\uC81C\uC758 \uC5ED\uD560\uC774 \uD544\uC218\uC801\uC774\uB2E4."@ko , "Unter Langzeit-Depression (eng: long-term depression, LTD) versteht man eine dauerhafte Abschw\u00E4chung der Signal\u00FCbertragung an den Synapsen von Nervenzellen. Zusammen mit ihrem Gegenst\u00FCck \u2013 der Langzeit-Potenzierung (LTP) stellt LTD eine der zellul\u00E4ren Grundlagen von Lernen und Ged\u00E4chtnis dar. Es wird heute gemeinhin angenommen, dass durch diese Formen von synaptischer Plastizit\u00E4t Informationen in Nervensystemen dauerhaft abgespeichert werden. Zwar ist es bislang noch nicht gelungen, Lernen direkt auf LTP und LTD zur\u00FCckzuf\u00FChren, es gibt aber eine Reihe indirekter Hinweise darauf, dass sie den zellul\u00E4ren Mechanismus bestimmter Lernformen darstellen."@de , "Em neurofisiologia, a depress\u00E3o de longa dura\u00E7\u00E3o (LTD) \u00E9 uma redu\u00E7\u00E3o dependente de atividade das sinapses neuronais que dura por horas, ou at\u00E9 mais, seguindo um est\u00EDmulo longo padronizado. A LTD ocorre em v\u00E1rias \u00E1reas do SNC com mecanismos variados dependendo da regi\u00E3o do enc\u00E9falo e no progresso do desenvolvimento. A LTD foi caracterizada principalmente no hipocampo e no cerebelo, por\u00E9m h\u00E1 outras \u00E1reas nas quais os mecanismos de LTD s\u00E3o compreendidos tamb\u00E9m. A LTD j\u00E1 foi encontrada em diferentes tipos de neur\u00F4nios, contudo, o neurotransmissor envolvido a maior parte das vezes na LTD \u00E9 o L-glutamato.O glutamato age em receptores N-metil-D- aspartato (NMDA), em receptores \u03B1-amino-3-hidr\u00F3xi-5-metilisoxazole-4-propionato (AMPA), receptores kainato (KA) e receptores metabotr\u00F3picos(mGluRs) durante a LTD. Ela pode resultar de estimula\u00E7\u00E3o sin\u00E1ptica forte (como ocorre nas do cerebelo) ou por estimula\u00E7\u00E3o sin\u00E1ptica fraca e persistente (como no hipocampo).Potencia\u00E7\u00E3o de longa dura\u00E7\u00E3o (LTP) \u00E9 o processo oposto \u00E0 LTD; \u00E9 o incremento duradouro na for\u00E7a da sinapse. Em conjunto, LTD e LTP s\u00E3o fatores que afetam a plasticidade neuronal sin\u00E1ptica. A LTD resulta da diminui\u00E7\u00E3o da densidade p\u00F3s-sin\u00E1ptica de , ainda que a diminui\u00E7\u00E3o da libera\u00E7\u00E3o pr\u00E9-sin\u00E1ptica de neurotransmissores possa tamb\u00E9m exercer um papel.A LTD cerebelar tem sido hipotetizada como importante para o , mas \u00E9 prov\u00E1vel que outros mecanismos participem tamb\u00E9m. A LTD no hipocampo, por sua vez, pode ser importante para a limpeza de mem\u00F3rias velhas. A LTD hipocampal/cortical pode ser dependente de receptores NMDA, receptores metabotr\u00F3picos (mGluR) ou endocanabin\u00F3ides. O resultado do mecanismo molecular de LTD subjacente \u00E9 a fosforila\u00E7\u00E3o dos receptores do tipo AMPA e a redu\u00E7\u00E3o dos mesmos na superf\u00EDcie p\u00F3s sin\u00E1ptica. LTD \u00E9 um dos diversos processos que servem para enfraquecer seletivamente sinapses espec\u00EDficas para fazer um uso construtivo do refor\u00E7o sin\u00E1ptico da LTP. Isso \u00E9 necess\u00E1rio pois, caso o aumento em for\u00E7a sin\u00E1ptica n\u00E3o fosse interrompido, as sinapses atingiriam um teto de efici\u00EAncia, que inibiria a codifica\u00E7\u00E3o de informa\u00E7\u00E3o."@pt , "\u9577\u671F\u6291\u5236\u4F5C\u7528\uFF08\u82F1\u8A9E\uFF1ALong-term depression\uFF0CLTD\uFF09\u53C8\u7A31\u9577\u6642\u7A0B\u6291\u5236\u4F5C\u7528\u3001\u957F\u671F\u6291\u52BF\uFF0C\u6307\u795E\u7ECF\u7A81\u89E6\u6301\u7EED\u51E0\u4E2A\u5C0F\u65F6\u5230\u51E0\u5929\u7684\u6291\u5236\u884C\u4E3A\u3002\u5F3A\u70C8\u7684\u7A81\u89E6\u523A\u6FC0\uFF08\u5C0F\u8111Purkinje\u7EC6\u80DE\uFF09\u6216\u8005\u957F\u671F\u7684\u5F31\u7A81\u89E6\u523A\u6FC0\uFF08\u6D77\u9A6C\u4F53\uFF09\u5747\u53EF\u5BFC\u81F4\u957F\u671F\u6291\u52BF\u7684\u5F62\u6210\u3002\u957F\u671F\u6291\u52BF\u88AB\u8BA4\u4E3A\u662F\u540E\u7A81\u89E6\u63A5\u53D7\u4F53\u5BC6\u5EA6\u7684\u6539\u53D8\u5BFC\u81F4\u7684\uFF0C\u4F46\u662F\u524D\u7A81\u89E6\u91CA\u653E\u7269\u7684\u6539\u53D8\u4E5F\u53EF\u80FD\u6709\u4E00\u5B9A\u5F71\u54CD\u3002\u5C0F\u8111\u7684\u957F\u671F\u6291\u52BF\u88AB\u5047\u5B9A\u5BF9\u8FD0\u52A8\u795E\u7ECF\u7684\u5B66\u4E60\u5177\u6709\u91CD\u8981\u4F5C\u7528\u3002\u6D77\u9A6C\u4F53\u7684\u957F\u671F\u6291\u52BF\u4E5F\u53EF\u80FD\u5BF9\u6E05\u9664\u8FC7\u53BB\u7684\u8BB0\u5FC6\u5177\u6709\u91CD\u8981\u4F5C\u7528\u3002\u6D77\u9A6C\u4F53/\u5927\u8111\u76AE\u5C42\u957F\u671F\u6291\u52BF\u53EF\u7531NMDA\u63A5\u53D7\u4F53\uFF0C\u4EE3\u8B1D\u578B\u9EA9\u80FA\u9178\u9E7D\u53D7\u9AD4\uFF08mGluR\uFF09\u6216\u8005endocannabinoids\u63A7\u5236\u3002"@zh , "\u0414\u043E\u0432\u0433\u043E\u0442\u0440\u0438\u0432\u0430\u043B\u0435 \u043F\u0440\u0438\u0433\u043D\u0456\u0447\u0435\u043D\u043D\u044F, \u0430\u0431\u043E \u0434\u043E\u0432\u0433\u043E\u0442\u0440\u0438\u0432\u0430\u043B\u0435 \u0441\u0438\u043D\u0430\u043F\u0442\u0438\u0447\u043D\u0435 \u043F\u0440\u0438\u0433\u043D\u0456\u0447\u0435\u043D\u043D\u044F (Long-Term Depression, LTD) - \u0432 \u043D\u0435\u0439\u0440\u043E\u0444\u0456\u0437\u0456\u043E\u043B\u043E\u0433\u0456\u0457 \u0437\u0430\u043B\u0435\u0436\u043D\u0430 \u0432\u0456\u0434 \u0430\u043A\u0442\u0438\u0432\u043D\u043E\u0441\u0442\u0456 \u043D\u0435\u0439\u0440\u043E\u043D\u043D\u0438\u0445 \u0441\u0438\u0433\u043D\u0430\u043B\u0456\u0432 \u0432\u0442\u0440\u0430\u0442\u0430 \u0435\u0444\u0435\u043A\u0442\u0438\u0432\u043D\u043E\u0441\u0442\u0456 \u0440\u043E\u0431\u043E\u0442\u0438 \u0441\u0438\u043D\u0430\u043F\u0441\u0456\u0432, \u0449\u043E \u043C\u043E\u0436\u0435 \u0442\u0440\u0438\u0432\u0430\u0442\u0438 \u0432\u0456\u0434 \u043A\u0456\u043B\u044C\u043A\u043E\u0445 \u0434\u0435\u0441\u044F\u0442\u043A\u0456\u0432 \u0445\u0432\u0438\u043B\u0438\u043D \u0434\u043E \u043A\u0456\u043B\u044C\u043A\u043E\u0445 \u0434\u0456\u0431. \u0412 \u0446\u0435\u043D\u0442\u0440\u0430\u043B\u044C\u043D\u0456\u0439 \u043D\u0435\u0440\u0432\u043E\u0432\u0456\u0439 \u0441\u0438\u0441\u0442\u0435\u043C\u0456, \u0437\u0430\u043B\u0435\u0436\u043D\u043E \u0432\u0456\u0434 \u0440\u0435\u0433\u0456\u043E\u043D\u0430 \u043C\u043E\u0437\u043A\u0443 \u0442\u0430 \u0441\u0442\u0430\u0434\u0456\u0457 \u0439\u043E\u0433\u043E \u0440\u043E\u0437\u0432\u0438\u0442\u043A\u0443, LTD \u043C\u043E\u0436\u0435 \u0431\u0443\u0442\u0438 \u0432\u0438\u043A\u043B\u0438\u043A\u0430\u043D\u0430 \u0440\u0456\u0437\u043D\u0438\u043C\u0438 \u043C\u0435\u0445\u0430\u043D\u0456\u0437\u043C\u0430\u043C\u0438. \u041D\u0430\u0439\u043A\u0440\u0430\u0449\u0435 \u0432\u0438\u0432\u0447\u0435\u043D\u0438\u043C\u0438 \u0454 \u043C\u0435\u0445\u0430\u043D\u0456\u0437\u043C\u0438 LTD \u0432 \u0433\u0456\u043F\u043E\u043A\u0430\u043C\u043F\u0456 \u0442\u0430 \u043C\u043E\u0437\u043E\u0447\u043A\u0443. \u0412 \u0433\u0456\u043F\u043E\u043A\u0430\u043C\u043F\u0456 LTD \u0432\u0438\u043A\u043B\u0438\u043A\u0430\u0454 \u0441\u043B\u0430\u0431\u043A\u0430, \u0430\u043B\u0435 \u0434\u043E\u0432\u0433\u043E\u0442\u0440\u0438\u0432\u0430\u043B\u0430 \u0441\u0442\u0438\u043C\u0443\u043B\u044F\u0446\u0456\u044F \u043D\u0435\u0439\u0440\u043E\u043D\u0456\u0432; \u043D\u0430\u0442\u043E\u043C\u0456\u0441\u0442\u044C \u0432 \u043C\u043E\u0437\u043E\u0447\u043A\u0443 \u0434\u043B\u044F \u0432\u0438\u043A\u043B\u0438\u043A\u0430\u043D\u043D\u044F LTD \u0441\u0442\u0438\u043C\u0443\u043B\u044F\u0446\u0456\u044F \u043C\u0430\u0454 \u0431\u0443\u0442\u0438 \u043D\u0430\u0431\u0430\u0433\u0430\u0442\u043E \u0441\u0438\u043B\u044C\u043D\u0456\u0448\u043E\u044E (\u044F\u043A \u043F\u043E\u043A\u0430\u0437\u0430\u043D\u043E \u043D\u0430 ). \u041E\u0441\u043D\u043E\u0432\u043D\u0438\u043C\u0438 \u043C\u0435\u0445\u0430\u043D\u0456\u0437\u043C\u0430\u043C\u0438 LTD \u0432\u0432\u0430\u0436\u0430\u044E\u0442\u044C\u0441\u044F \u0437\u043D\u0438\u0436\u0435\u043D\u043D\u044F \u043A\u0456\u043B\u044C\u043A\u043E\u0441\u0442\u0456 \u0440\u0435\u0446\u0435\u043F\u0442\u043E\u0440\u0456\u0432 \u043D\u0430 \u043F\u043E\u0441\u0442\u0441\u0438\u043D\u0430\u043F\u0442\u0438\u0447\u043D\u0456\u0439 \u043C\u0435\u043C\u0431\u0440\u0430\u043D\u0456, \u0430 \u0442\u0430\u043A\u043E\u0436 \u0437\u043D\u0438\u0436\u0435\u043D\u043D\u044F \u0435\u0444\u0435\u043A\u0442\u0438\u0432\u043D\u043E\u0441\u0442\u0456 \u0432\u0438\u0432\u0456\u043B\u044C\u043D\u0435\u043D\u043D\u044F \u043D\u0435\u0439\u0440\u043E\u043C\u0435\u0434\u0456\u0430\u0442\u043E\u0440\u0430 \u0437 \u043F\u0440\u0435\u0441\u0438\u043D\u0430\u043F\u0442\u0438\u0447\u043D\u043E\u0433\u043E \u0431\u0443\u0442\u043E\u043D\u0430. LTD \u0432 \u043C\u043E\u0437\u043E\u0447\u043A\u0443 \u0432\u0432\u0430\u0436\u0430\u0454\u0442\u044C\u0441\u044F \u043F\u0440\u043E\u0446\u0435\u0441\u043E\u043C, \u0449\u043E \u0432\u0456\u0434\u0456\u0433\u0440\u0430\u0454 \u0437\u043D\u0430\u0447\u043D\u0443 \u0440\u043E\u043B\u044C \u0432 \u0444\u043E\u0440\u043C\u0443\u0432\u0430\u043D\u043D\u0456 \u0440\u0443\u0448\u0456\u0439\u043D\u043E\u0457 \u043F\u0430\u043C'\u044F\u0442\u0456; \u043D\u0430\u0442\u043E\u043C\u0456\u0441\u0442\u044C LTD \u0432 \u0433\u0456\u043F\u043E\u043A\u0430\u043C\u043F\u0456, \u0437\u0433\u0456\u0434\u043D\u043E \u0437 \u0440\u0435\u0437\u0443\u043B\u044C\u0442\u0430\u0442\u0430\u043C\u0438 \u0440\u044F\u0434\u0443 \u0434\u043E\u0441\u043B\u0456\u0434\u0436\u0435\u043D\u044C, \u0432\u0456\u0434\u0456\u0433\u0440\u0430\u0454 \u0437\u043D\u0430\u0447\u043D\u0443 \u0440\u043E\u043B\u044C \u0432 \u0444\u043E\u0440\u043C\u0443\u0432\u0430\u043D\u043D\u0456 \u0434\u043E\u0432\u0433\u043E\u0442\u0440\u0438\u0432\u0430\u043B\u0438\u0445 \u0441\u043F\u043E\u0433\u0430\u0434\u0456\u0432. \u0412 \u0444\u043E\u0440\u043C\u0443\u0432\u0430\u043D\u043D\u0456 \u0433\u0456\u043F\u043E\u043A\u0430\u043C\u043F\u0430\u043B\u044C\u043D\u043E\u0433\u043E LTD \u043F\u043E\u043C\u0456\u0442\u043D\u0443 \u0440\u043E\u043B\u044C \u0432\u0456\u0434\u0456\u0433\u0440\u0430\u044E\u0442\u044C NMDA-, \u0410\u041C\u0420\u0410-, \u043C\u0435\u0442\u0430\u0431\u043E\u0442\u0440\u043E\u043F\u043D\u0456 \u0433\u043B\u0443\u0442\u0430\u043C\u0430\u0442\u043D\u0456 \u0442\u0430 \u043A\u0430\u043D\u0430\u0431\u0456\u043D\u043E\u0457\u0434\u043D\u0456 \u0440\u0435\u0446\u0435\u043F\u0442\u043E\u0440\u0438. \u0417\u0430\u0433\u0430\u043B\u043E\u043C LTD \u0440\u0430\u0437\u043E\u043C \u0437 LTP \u0454 \u0434\u0432\u043E\u043C\u0430 \u043E\u0441\u043D\u043E\u0432\u043D\u0438\u043C\u0438 \u043C\u0435\u0445\u0430\u043D\u0456\u0437\u043C\u0430\u043C\u0438, \u0449\u043E \u0431\u0430\u043B\u0430\u043D\u0441\u0443\u044E\u0442\u044C \u0441\u0438\u0433\u043D\u0430\u043B\u044C\u043D\u0443 \u0430\u043A\u0442\u0438\u0432\u043D\u0456\u0441\u0442\u044C \u0432 \u043D\u0435\u0440\u0432\u043E\u0432\u0456\u0439 \u0441\u0438\u0441\u0442\u0435\u043C\u0456."@uk ; 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