About: Amphinase

An Entity of Type: protein, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Amphinase is a ribonuclease enzyme found in the oocytes of the Northern leopard frog (Rana pipiens). Amphinase is a member of the pancreatic ribonuclease protein superfamily and degrades long RNA substrates. Along with ranpirnase, another leopard frog ribonuclease, amphinase has been studied as a potential cancer therapy due to its unusual mechanism of cytotoxicity tested against tumor cells.

Property	Value
dbo:abstract	Amphinase is a ribonuclease enzyme found in the oocytes of the Northern leopard frog (Rana pipiens). Amphinase is a member of the pancreatic ribonuclease protein superfamily and degrades long RNA substrates. Along with ranpirnase, another leopard frog ribonuclease, amphinase has been studied as a potential cancer therapy due to its unusual mechanism of cytotoxicity tested against tumor cells. (en) L'amphinase est une ribonucléase présente dans les ovocytes de la grenouille léopard (Rana pipiens). Elle est de la même famille que la ribonucléase pancréatique et clive les molécules d'ARN de grande taille. Avec la ranpirnase, autre ribonucléase des ovocytes de la grenouille léopard, elle a fait l'objet d'études infructueuses afin d'évaluer son potentiel thérapeutique en raison de sa cytotoxicité sélective contre les cellules cancéreuses. (fr)
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dbo:wikiPageRevisionID	917334740 (xsd:integer)
dbo:wikiPageWikiLink	dbr:Cancer dbc:EC_3.1.27 dbc:Ribonucleases dbr:Ribonuclease dbr:Cytotoxicity dbr:Northern_leopard_frog dbr:Oocytes dbr:Enzyme dbr:Crystallography dbr:Substrate_(chemistry) dbr:Tumor dbr:Pancreatic_ribonuclease dbr:RNA dbr:Ranpirnase
dbp:caption	Crystallographic structure of amphinase. (en)
dbp:ecnumber	3.100000 (xsd:double)
dbp:name	Amphinase (en)
dbp:organism	Rana pipiens (en)
dbp:pdb	2 (xsd:integer)
dbp:symbol	n/a (en)
dbp:taxid	8404 (xsd:integer)
dbp:uniprot	P85073 (en)
dbp:wikiPageUsesTemplate	dbt:3.1-enzyme-stub dbt:Enzymes dbt:Esterases dbt:Infobox_nonhuman_protein dbt:Portal_bar dbt:Reflist
dct:subject	dbc:EC_3.1.27 dbc:Ribonucleases
gold:hypernym	dbr:Enzyme
rdf:type	dbo:Protein
rdfs:comment	Amphinase is a ribonuclease enzyme found in the oocytes of the Northern leopard frog (Rana pipiens). Amphinase is a member of the pancreatic ribonuclease protein superfamily and degrades long RNA substrates. Along with ranpirnase, another leopard frog ribonuclease, amphinase has been studied as a potential cancer therapy due to its unusual mechanism of cytotoxicity tested against tumor cells. (en) L'amphinase est une ribonucléase présente dans les ovocytes de la grenouille léopard (Rana pipiens). Elle est de la même famille que la ribonucléase pancréatique et clive les molécules d'ARN de grande taille. Avec la ranpirnase, autre ribonucléase des ovocytes de la grenouille léopard, elle a fait l'objet d'études infructueuses afin d'évaluer son potentiel thérapeutique en raison de sa cytotoxicité sélective contre les cellules cancéreuses. (fr)
rdfs:label	Amphinase (en) Amphinase (fr)
owl:sameAs	freebase:Amphinase wikidata:Amphinase dbpedia-fr:Amphinase https://global.dbpedia.org/id/4PH8F
prov:wasDerivedFrom	wikipedia-en:Amphinase?oldid=917334740&ns=0
foaf:depiction	wiki-commons:Special:FilePath/2P7S.png
foaf:isPrimaryTopicOf	wikipedia-en:Amphinase
is dbo:wikiPageWikiLink of	dbr:Ribonuclease_inhibitor dbr:Northern_leopard_frog dbr:Pancreatic_ribonuclease_family dbr:Ranpirnase
is foaf:primaryTopic of	wikipedia-en:Amphinase

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