Andrimid is an antibiotic natural product that is produced by the marine bacterium Vibrio coralliilyticus. Andrimid is an inhibitor of fatty acid biosynthesis by blocking the carboxyl transfer reaction of acetyl-CoA carboxylase (ACC). Andrimid contains a pseudopeptide backbone and is synthesized through the polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS) pathways. Amino acids are added by the NRPS pathway which loads amino acid monomer units into the growing chain during the molecular assembly line.
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