Location via proxy:   [ UP ]  
[Report a bug]   [Manage cookies]                

About: Safingol

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Safingol is a lyso-sphingolipid protein kinase inhibitor. It has the molecular formula C18H39NO2 and is a colorless solid. Medicinally, safingol has demonstrated promising anticancer potential as a modulator of multi-drug resistance and as an inducer of necrosis. The administration of safingol alone has not been shown to exert a significant effect on tumor cell growth. However, preclinical and clinical studies have shown that combining safingol with conventional chemotherapy agents such as fenretinide, vinblastine, irinotecan and mitomycin C can dramatically potentiate their antitumor effects. Currently in Phase I clinical trials, it is believed to be safe to co-administer with cisplatin.

thumbnail
Property Value
dbo:abstract
  • Safingol is a lyso-sphingolipid protein kinase inhibitor. It has the molecular formula C18H39NO2 and is a colorless solid. Medicinally, safingol has demonstrated promising anticancer potential as a modulator of multi-drug resistance and as an inducer of necrosis. The administration of safingol alone has not been shown to exert a significant effect on tumor cell growth. However, preclinical and clinical studies have shown that combining safingol with conventional chemotherapy agents such as fenretinide, vinblastine, irinotecan and mitomycin C can dramatically potentiate their antitumor effects. Currently in Phase I clinical trials, it is believed to be safe to co-administer with cisplatin. (en)
dbo:alternativeName
  • (−)-threo-Dihydrosphingosine; (2S,3S)-2-Amino-1,3-octadecanediol; (L)-(−)-threo-Sphinganine; (L)-threo-Dihydrosphingosine; (L)-threo-2-Amino-1,3-octadecanediol; threo-1,3-Dihydroxy-2-aminooctadecane (en)
dbo:iupacName
  • (2S,3S)-2-Aminooctadecane-1,3-diol (en)
dbo:thumbnail
dbo:wikiPageID
  • 27285703 (xsd:integer)
dbo:wikiPageLength
  • 8241 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID
  • 1021455818 (xsd:integer)
dbo:wikiPageWikiLink
dbp:imagefile
  • Safingol.png (en)
dbp:imagesize
  • 200 (xsd:integer)
dbp:othernames
  • -threo-Dihydrosphingosine; -2-Amino-1,3-octadecanediol; (L)--threo-Sphinganine; (L)-threo-Dihydrosphingosine; (L)-threo-2-Amino-1,3-octadecanediol; threo-1,3-Dihydroxy-2-aminooctadecane (en)
dbp:pin
  • -2 (xsd:integer)
dbp:verifiedfields
  • changed (en)
dbp:verifiedrevid
  • 444554602 (xsd:integer)
dbp:watchedfields
  • changed (en)
dbp:wikiPageUsesTemplate
dcterms:subject
gold:hypernym
rdf:type
rdfs:comment
  • Safingol is a lyso-sphingolipid protein kinase inhibitor. It has the molecular formula C18H39NO2 and is a colorless solid. Medicinally, safingol has demonstrated promising anticancer potential as a modulator of multi-drug resistance and as an inducer of necrosis. The administration of safingol alone has not been shown to exert a significant effect on tumor cell growth. However, preclinical and clinical studies have shown that combining safingol with conventional chemotherapy agents such as fenretinide, vinblastine, irinotecan and mitomycin C can dramatically potentiate their antitumor effects. Currently in Phase I clinical trials, it is believed to be safe to co-administer with cisplatin. (en)
rdfs:label
  • Safingol (en)
owl:sameAs
prov:wasDerivedFrom
foaf:depiction
foaf:isPrimaryTopicOf
is dbo:wikiPageRedirects of
is dbo:wikiPageWikiLink of
is foaf:primaryTopic of
Powered by OpenLink Virtuoso    This material is Open Knowledge     W3C Semantic Web Technology     This material is Open Knowledge    Valid XHTML + RDFa
This content was extracted from Wikipedia and is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License