About: Sonlicromanol

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Sonlicromanol (KH176) is a clinical-stage oral drug compound developed by Khondrion as a potential treatment for inherited mitochondrial diseases, such as Leigh's Disease, MELAS and LHON. Due to dysfunctional mitochondria, an increased level of cellular reactive oxygen species (ROS) is observed in these patients, causing a wide range of symptoms. The active metabolite of Sonlicromanol (KH176m, or KH183) has several mechanisms of action, acting both as antioxidant and as reactive oxygen species (ROS)-redox modulator. Through selective suppression of microsomal prostaglandin E synthase-1 (mPGES-1), Sonlicromanol even has potency as anti-cancer drug for mPGES-1 overexpressing cancer like prostate cancer. Currently, Sonlicromanol is in phase II clinical trial in the KHENERGYZE, KHENEREXT and K

Property	Value
dbo:abstract	Sonlicromanol (KH176) is a clinical-stage oral drug compound developed by Khondrion as a potential treatment for inherited mitochondrial diseases, such as Leigh's Disease, MELAS and LHON. Due to dysfunctional mitochondria, an increased level of cellular reactive oxygen species (ROS) is observed in these patients, causing a wide range of symptoms. The active metabolite of Sonlicromanol (KH176m, or KH183) has several mechanisms of action, acting both as antioxidant and as reactive oxygen species (ROS)-redox modulator. Through selective suppression of microsomal prostaglandin E synthase-1 (mPGES-1), Sonlicromanol even has potency as anti-cancer drug for mPGES-1 overexpressing cancer like prostate cancer. Currently, Sonlicromanol is in phase II clinical trial in the KHENERGYZE, KHENEREXT and KHENERGYC studies as potent candidate in treatment for mitochondrial diseases. (en)
dbo:alternativeName	(en) * KH-176 (en) * (2S)-3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-N-(3R)-3-piperidinyl-2H-1-benzopyran-2-carboxamide (en)
dbo:iupacName	(2S)-6-Hydroxy-2,5,7,8-tetramethyl-N-[(3R)-piperidin-3-yl]-3,4-dihydrochromene-2-carboxamide (en)
dbo:thumbnail	wiki-commons:Special:FilePath/Sonlicromanol.svg?width=300
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dbo:wikiPageWikiLink	dbr:MELAS_syndrome dbr:Hydrogen_peroxide dbr:MPGES-1 dbc:Alcohols dbc:Piperidines dbr:Peroxiredoxin dbr:Prostate_cancer dbr:Thioredoxin dbc:Carboxamides dbr:Oxidative_phosphorylation dbr:Leigh_syndrome dbr:Post_hoc_analysis dbc:Chromanes dbr:Superoxide dbr:Diabetes dbr:Cytochrome_P450_3A4 dbr:Migraine dbr:Oxidative_stress dbr:LHON dbr:File:Sonlicromanol_and_metabolite.png
dbp:imagefile	Sonlicromanol.svg (en)
dbp:iupacname	-6 (xsd:integer)
dbp:name	Sonlicromanol (en)
dbp:othernames	(en) * KH-176 * -3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-N--3-piperidinyl-2H-1-benzopyran-2-carboxamide (en)
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dcterms:subject	dbc:Alcohols dbc:Piperidines dbc:Carboxamides dbc:Chromanes
rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 dbo:ChemicalCompound
rdfs:comment	Sonlicromanol (KH176) is a clinical-stage oral drug compound developed by Khondrion as a potential treatment for inherited mitochondrial diseases, such as Leigh's Disease, MELAS and LHON. Due to dysfunctional mitochondria, an increased level of cellular reactive oxygen species (ROS) is observed in these patients, causing a wide range of symptoms. The active metabolite of Sonlicromanol (KH176m, or KH183) has several mechanisms of action, acting both as antioxidant and as reactive oxygen species (ROS)-redox modulator. Through selective suppression of microsomal prostaglandin E synthase-1 (mPGES-1), Sonlicromanol even has potency as anti-cancer drug for mPGES-1 overexpressing cancer like prostate cancer. Currently, Sonlicromanol is in phase II clinical trial in the KHENERGYZE, KHENEREXT and K (en)
rdfs:label	Sonlicromanol (en)
owl:sameAs	wikidata:Sonlicromanol https://global.dbpedia.org/id/2bniQ
prov:wasDerivedFrom	wikipedia-en:Sonlicromanol?oldid=1097963702&ns=0
foaf:depiction	wiki-commons:Special:FilePath/Sonlicromanol.svg wiki-commons:Special:FilePath/Sonlicromanol_and_metabolite.png
foaf:isPrimaryTopicOf	wikipedia-en:Sonlicromanol
foaf:name	Sonlicromanol (en)
is foaf:primaryTopic of	wikipedia-en:Sonlicromanol

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