Fluocinonide
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| Clinical data | |
|---|---|
| Trade names | Fluonex, Lidex, others[1] |
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
| MedlinePlus | a601054 |
| Routes of administration | Topical |
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| Pharmacokinetic data | |
| Metabolism | hepatic |
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| DrugBank | |
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| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.005.998 |
| Chemical and physical data | |
| Formula | C26H32F2O7 |
| Molar mass | 494.532 g·mol−1 |
| 3D model (JSmol) | |
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Fluocinonide (sold under various brand names) is a potent glucocorticoid used topically as an anti-inflammatory agent for the treatment of skin disorders such as eczema and seborrhoeic dermatitis.[3] It relieves itching, redness, dryness, crusting, scaling, inflammation, and discomfort.[3]
A common potential adverse effect is skin atrophy (thinning of the skin).[4] Systemic absorption of topical corticosteroids can produce reversible hypothalamic-pituitary-adrenal axis (HPA) suppression, manifestations of Cushing's syndrome, hyperglycemia, and glucosuria.[medical citation needed]
In 2020, it was the 280th most commonly prescribed medication in the United States, with more than 1 million prescriptions.[5][6]
Veterinary uses
Fluocinonide is used in veterinary medicine. It is a treatment for allergies in dogs.[7] Natural systemic cortisol concentrations can be suppressed for weeks after one week of topical exposure.[8]
References
- ^ MedlinePlus Drug Information: Fluocinonide Topical
- ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
- ^ a b "Fluocinonide Topical: MedlinePlus Drug Information". medlineplus.gov. Retrieved 2022-11-16.
- ^ Jablonska, S.; Groniowska, M.; Dabroswki, J. (February 1979). "Comparative evaluation of skin atrophy in man induced by topical corticoids". The British Journal of Dermatology. 100 (2): 193–206. doi:10.1111/j.1365-2133.1979.tb05561.x. ISSN 0007-0963. PMID 154921.
- ^ "The Top 300 of 2020". ClinCalc. Retrieved 7 October 2022.
- ^ "Fluocinonide - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.
- ^ Dog Allergies www.squidoo.com/dogallergy
- ^ Zenoble RD, Kemppainen RJ (September 1987). "Adrenocortical suppression by topically applied corticosteroids in healthy dogs". Journal of the American Veterinary Medical Association. 191 (6): 685–8. PMID 2824410.
External links
- "Fluocinonide". Drug Information Portal. U.S. National Library of Medicine.
