Abstract
The synthesis of a novel PS conjugated with bovine and human serum albumin (BSA and HSA) and a monoclonal antibody anti-CD104 is reported, as well as their biological potential against the human bladder cancer cell line UM-UC-3. No photodynamic effect was detected when the non-conjugated porphyrin was used. Yet, when it was coupled covalently with the mAb anti-CD104, BSA and HSA, the resulting photosensitizer conjugates demonstrated high efficacy in destroying the cancer cells, the mAb anti-CD104 efficacy overruling the albumins.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibodies, Monoclonal / chemistry*
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Cell Line, Tumor
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Enzyme-Linked Immunosorbent Assay
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Humans
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Photochemotherapy
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Photosensitizing Agents / chemistry*
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Photosensitizing Agents / therapeutic use
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Porphyrins / chemistry*
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Reactive Oxygen Species / metabolism
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Serum Albumin / chemistry*
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Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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Urinary Bladder Neoplasms / drug therapy
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Urinary Bladder Neoplasms / metabolism
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Urinary Bladder Neoplasms / pathology*
Substances
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Antibodies, Monoclonal
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Photosensitizing Agents
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Porphyrins
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Reactive Oxygen Species
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Serum Albumin