We discuss recent developments in exploring supply chain structural dynamics. We focus on both positive (i.e., new disruptive technologies) and negative (i.e., disruption risks) triggers of the structural dynamics in complex supply chain networks. We discuss papers in the special issue which focus on supply chain structural dynamics using different methods, collating and presenting recent research in the field. In particular, the ripple effect, blockchain, network resilience, data analytics, and service platforms have been identified as the leading research directions.