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Recent Citations

Molecular architecture of coronavirus double-membrane vesicle pore complex. Huang Y, Wang T et al. Nature. 2024 Sep 5;633(8028):224–231.

FANCD2-FANCI surveys DNA and recognizes double- to single-stranded junctions. Alcón P, Kaczmarczyk AP et al. Nature. 2024 Aug 29;632(8027):1165–1173.

Transport and inhibition mechanisms of the human noradrenaline transporter. Hu T, Yu Z et al. Nature. 2024 Aug 22;632(8026):930–937.

Cryo-EM architecture of a near-native stretch-sensitive membrane microdomain. Kefauver JM, Hakala M et al. Nature. 2024 Aug 15;632(8025):664-671.

An integrative structural study of the human full-length RAD52 at 2.2 Å resolution. Balboni B, Marotta R et al. Commun Biol. 2024 Aug 8;7(1):956.

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August 1, 2024

Planned downtime: The Chimera and ChimeraX websites, web services (Blast Protein, Modeller, ...) and cgl.ucsf.edu e-mail will be unavailable August 1, 3-6 pm PDT.

July 16, 2024

Chimera production release 1.18 is now available. See the release notes for details.

June 17-18, 2024

Planned downtime: The Chimera and ChimeraX websites, web services (Blast Protein, Modeller, ...) and cgl.ucsf.edu e-mail will be unavailable June 17-18 PDT.

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Upcoming Events

Please note that UCSF Chimera is legacy software that is no longer being developed or supported. Users are strongly encouraged to try UCSF ChimeraX, which is under active development.

UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.

We encourage Chimera users to try ChimeraX for much better performance with large structures, as well as other major advantages and completely new features in addition to nearly all the capabilities of Chimera (details...).

Chimera is no longer under active development. Chimera development was supported by a grant from the National Institutes of Health (P41-GM103311) that ended in 2018.

Feature Highlight

Thermal Ellipsoids

Anisotropic B-factors can be shown as ellipsoids, with ellipsoid axes and radii representing the eigenvectors and eigenvalues of the atomic mean-square displacement matrix. Anisotropic B-factors are read from the input coordinate file (for example, from ANISOU records in a PDB file) and can be displayed with the tool Thermal Ellipsoids or the command aniso. The figure shows ellipsoids scaled to enclose 50% probability for the heme and nearby atoms from PDB entry 1a6m.

(More features...)

Gallery Sample

Peroxiredoxin Wreath

Peroxiredoxins are enzymes that help cells cope with stressors such as high levels of reactive oxygen species. The image shows a decameric peroxiredoxin from human red blood cells (Protein Data Bank entry 1qmv), styled as a holiday wreath.

See also the RBVI holiday card gallery.

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