Proplatelet formation is a terminal process, and once it has been completed the residual megakaryocyte nucleus is engulfed by macrophages within the bone marrow ...

Bone marrow megakaryocytes produce platelets by extending long cytoplasmic protrusions, designated proplatelets, into sinusoidal blood vessels.

This report describes a model system in which functional platelets are generated in vitro from human megakaryocytes.

Jun 19, 2024 · We identified KIFC1- and cell cycle–mediated centrosome clustering as an important initiator of proplatelet formation from MKs.

We found that D-dencichine was efficient in promoting megakaryocyte adhesion, migration, and proplatelet formation (PPF) through ERK1/2 and Akt signaling ...

After vessel injury, subendothelial collagen becomes exposed and induces platelet activation to prevent blood loss. Collagen types I and IV are thought to have ...

Objective: To analyse the regulation of proplatelet formation by megakaryocyte adhesion to extracellular adhesive proteins through different membrane receptors.

Dec 19, 2018 · In summary, our results unveiled a novel function of C3G as a promoter of megakaryocyte differentiation, maturation and proplatelet formation.

Proplatelet formation is a terminal process, and once it has been completed the residual megakaryocyte nucleus is engulfed by macrophages within the bone marrow ...