foreword

Immunology p1

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News and Views

Dual personality of memory T cells p3

Charles R. Mackay

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Toll gates for pathogen selection p5

Richard J. Ulevitch

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Review

Selecting and maintaining a diverse T-cell repertoire p6

Ananda W. Goldrath and Michael J. Bevan

Abstract | Full Text | PDF (228K)

Article

Commitment to the B-lymphoid lineage depends on the transcription factor Pax5 p14

Stephen L. Nutt, Barry Heavey, Antonius G. Rolink and Meinrad Busslinger

Abstract | Full Text | PDF (422K)

Letters to Nature

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28 p21

Andreas Hutloff, Anna M. Dittrich, Katja C. Beier, Barbara Eljaschewitsch, Regine Kraft, Ionnis Anagnostopoulos and Richard A. Kroczek

First paragraph | Full Text | PDF (261K)

Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen p25

Luis J. Sigal, Shane Crotty, Raul Andino and Kenneth L. Rock

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Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase p29

Wuyi Meng, Sansana Sawasdikosol, Steven J. Burakoff and Michael J. Eck

First paragraph | Full Text | PDF (659K)

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions p34

Federica Sallusto, Danielle Lenig, Reinhold Förster, Martin Lipp and Antonio Lanzavecchia

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The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens p39

David M. Underhill, Adrian Ozinsky, Adeline M. Hajjar, Anne Stevens, Christopher B. Wilson, Michael Bassetti and Alan Aderem

First paragraph | Full Text | PDF (230K) | Supplementary information

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand p43

Young-Yun Kong, Ulrich Feige, Iidiko Sarosi, Brad Bolon, Anna Tafuri, Sean Morony, Casey Capparelli, Ji Li, Robin Elliott, Susan McCabe, Thomas Wong, Giuseppe Campagnuolo, Erika Moran, Earl R. Bogoch, Gwyneth Van, Linh T. Nguyen, Pamela S. Ohashi, David L. Lacey, Eleanor Fish, William J. Boyle and Josef M. Penninger

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sponsors

Biogen and immune disease p48

Joseph M. Davie, MD PhD, Senior Vice President–Research

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