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Series GSE8401

Query DataSets for GSE8401

Status

Public on Oct 02, 2007

Title

Gene Signature for Aggression of Melanoma Metastases - Melanoma Metastasis

Organism

Homo sapiens

Experiment type

Expression profiling by array

Summary

Metastasis is the deadliest phase of cancer progression. Experimental models using immunodeficient mice have been used to gain insights into the mechanisms of metastasis. We report here the identification of a “metastasis aggressiveness gene expression signature” derived using human melanoma cells selected based on their metastatic potentials in a xenotransplant metastasis model. Comparison with expression data from human melanoma patients shows that this metastasis gene signature correlates with the aggressiveness of melanoma metastases in human patients. Many genes encoding secreted and membrane proteins are included in the signature, suggesting the importance of tumor-microenvironment interactions during metastasis.
Keywords: disease state

Overall design

test signature genereated from experiments of parental cell line vs xenograft model

Contributor(s)

Xu L, Shen S, Hynes R

Citation(s)

18505921, 23935925

Submission date

Jul 06, 2007

Last update date

Sep 16, 2019

Contact name

steve shen

E-mail(s)

ssshen@mit.edu

Organization name

MIT

Street address

77 mass ave

City

cambridge

State/province

ZIP/Postal code

02139

Country

USA

Platforms (1)

GPL96

[HG-U133A] Affymetrix Human Genome U133A Array

Samples (83)

More...

GSM207929	Human cancer, primary melanoma (Prim Nr 87/3)
GSM207930	Human cancer, primary melanoma (Prim Nr 89/4)
GSM207931	Human cancer, primary melanoma (Prim Nr 90/6)

GSM207932	Human cancer, primary melanoma (Prim Nr 74/5)
GSM207933	Human cancer, primary melanoma (Prim Nr 90/5)
GSM207934	Human cancer, primary melanoma (Prim Nr 103/1)
GSM207935	Human cancer, primary melanoma (Prim Nr 78/2)
GSM207936	Human cancer, primary melanoma (Prim Nr 71/5 )
GSM207937	Human cancer, primary melanoma (Prim Nr 15/5)
GSM207938	Human cancer, primary melanoma (Prim Nr 20/1)
GSM207939	Human cancer, primary melanoma (Prim Nr 89/2)
GSM207940	Human cancer, primary melanoma (Prim Nr 8/3)
GSM207941	Human cancer, primary melanoma (Prim Nr 72/4)
GSM207942	Human cancer, primary melanoma (Prim Nr 90/3)
GSM207943	Human cancer, primary melanoma (Prim Nr 72/2 )
GSM207944	Human cancer, primary melanoma (Prim Nr 104/5)
GSM207945	Human cancer, primary melanoma (Prim Nr 89/5)
GSM207946	Human cancer, primary melanoma (Prim Nr 104/6)
GSM207947	Human cancer, primary melanoma (Prim Nr 103/2)
GSM207948	Human cancer, primary melanoma (Prim Nr 102/5)
GSM207949	Human cancer, primary melanoma (Prim Nr 103/3)
GSM207950	Human cancer, primary melanoma (Prim Nr 103/4)
GSM207951	Human cancer, primary melanoma (Prim Nr 106/1)
GSM207952	Human cancer, primary melanoma (Prim Nr 103/5)
GSM207953	Human cancer, primary melanoma (Prim Nr 106/2)
GSM207954	Human cancer, primary melanoma (Prim Nr 102/6)
GSM207955	Human cancer, primary melanoma (Prim Nr 106/3)
GSM207956	Human cancer, primary melanoma (Prim Nr 89/6)
GSM207957	Human cancer, primary melanoma (Prim Nr 107/5)
GSM207958	Human cancer, primary melanoma (Prim Nr 107/4)
GSM207959	Human cancer, primary melanoma (Prim Nr 79/3)
GSM207960	Human cancer, melanoma metastasis (Met Nr 68/4)
GSM207961	Human cancer, melanoma metastasis (Met Nr 67/6)
GSM207962	Human cancer, melanoma metastasis (Met Nr 66/4)
GSM207963	Human cancer, melanoma metastasis (Met Nr 65/2)
GSM207964	Human cancer, melanoma metastasis (Met Nr. 99/2)
GSM207965	Human cancer, melanoma metastasis (Met Nr. 101/6)
GSM207966	Human cancer, melanoma metastasis (Met Nr 67/3)
GSM207967	Human cancer, melanoma metastasis (Met Nr 66/1)
GSM207968	Human cancer, melanoma metastasis (Met Nr 64/5)
GSM207969	Human cancer, melanoma metastasis (Met Nr. 99/3)
GSM207970	Human cancer, melanoma metastasis (Met Nr 15/3)
GSM207971	Human cancer, melanoma metastasis (Met Nr 18/2)
GSM207972	Human cancer, melanoma metastasis (Met Nr 18/4)
GSM207973	Human cancer, melanoma metastasis (Met Nr 64/1)
GSM207974	Human cancer, melanoma metastasis (met Nr 64/2)
GSM207975	Human cancer, melanoma metastasis (Met Nr 64/3)
GSM207976	Human cancer, melanoma metastasis (Met Nr 64/4)
GSM207977	Human cancer, melanoma metastasis (Met Nr 65/3)
GSM207978	Human cancer, melanoma metastasis (Met Nr 65/4)
GSM207979	Human cancer, melanoma metastasis (Met Nr 66/5)
GSM207980	Human cancer, melanoma metastasis (Met Nr 66/6)
GSM207981	Human cancer, melanoma metastasis (Met Nr 67/4)
GSM207982	Human cancer, melanoma metastasis (Met Nr 67/5)
GSM207983	Human cancer, melanoma metastasis (Met Nr 68/2)
GSM207984	Human cancer, melanoma metastasis (Met Nr 68/6)
GSM207985	Human cancer, melanoma metastasis (Met Nr 69/1)
GSM207986	Human cancer, melanoma metastasis (Met Nr 69/2)
GSM207987	Human cancer, melanoma metastasis (Met Nr 69/4)
GSM207988	Human cancer, melanoma metastasis (Met Nr 69/5)
GSM207989	Human cancer, melanoma metastasis (Met Nr 88/5)
GSM207990	Human cancer, melanoma metastasis (Met Nr 89/1)
GSM207991	Human cancer, melanoma metastasis (Met Nr 89/3)
GSM207992	Human cancer, melanoma metastasis (Met Nr 91/1)
GSM207993	Human cancer, melanoma metastasis (Met Nr 91/2)
GSM207994	Human cancer, melanoma metastasis (Met Nr 92/5)
GSM207995	Human cancer, melanoma metastasis (Met Nr 92/6)
GSM207996	Human cancer, melanoma metastasis (Met Nr 105/1)
GSM207997	Human cancer, melanoma metastasis (Met Nr 105/6)
GSM207998	Human cancer, melanoma metastasis (Met Nr 104/2)
GSM207999	Human cancer, melanoma metastasis (Met Nr 105/3)
GSM208000	Human cancer, melanoma metastasis (Met Nr 99/4)
GSM208001	Human cancer, melanoma metastasis (Met Nr 102/2)
GSM208002	Human cancer, melanoma metastasis (Met Nr 105/2)
GSM208003	Human cancer, melanoma metastasis (Met Nr 104/3)
GSM208004	Human cancer, melanoma metastasis (Met Nr 99/6)
GSM208005	Human cancer, melanoma metastasis (Met Nr 105/4)
GSM208006	Human cancer, melanoma metastasis (Met Nr 105/5)
GSM208007	Human cancer, melanoma metastasis (Met Nr 104/4)
GSM208008	Human cancer, melanoma metastasis (Met Nr 69/3)
GSM208009	Human cancer, melanoma metastasis (Met Nr 69/6)
GSM208010	Human cancer, melanoma metastasis (Met Nr 66/2)
GSM208011	Human cancer, melanoma metastasis (Met Nr 92/3)

Relations

BioProject

PRJNA101453

Download family	Format
SOFT formatted family file(s)	SOFT
MINiML formatted family file(s)	MINiML
Series Matrix File(s)	TXT

Supplementary file	Size	Download	File type/resource
GSE8401_RAW.tar	279.7 Mb	(http)(custom)	TAR (of CEL)
Processed data included within Sample table