Abstract
The possible role of quercetin, a naturally occurring plant flavonoid, in protecting against oxygen-glucose deprivation (OGD)-, excitotoxins-, and free radical-induced neuronal injury in mouse cortical cell cultures was investigated. Pre- and co-treatment with quercetin (100 microM) inhibited 50 min OGD-, 20 microM N-methyl-D-aspartate (NMDA)-, and 50 microM kainate-induced neurotoxicity by 36, 22, and 61%, respectively. Quercetin significantly ameliorated free radical-induced neuronal injury caused by buthionine sulfoximine, sodium nitroprusside, ZnCl(2), and FeCl(2). These results suggest that quercetin may contribute a neuroprotective action against ischemic neural injury, partially via antioxidant actions.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antioxidants / pharmacology
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Cell Hypoxia / drug effects
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Cell Hypoxia / physiology
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Cells, Cultured
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Cerebral Cortex / drug effects*
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Cerebral Cortex / pathology
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Cerebral Cortex / physiology
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Dose-Response Relationship, Drug
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Excitatory Amino Acid Agonists / toxicity*
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Glucose / deficiency*
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Kainic Acid / toxicity
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Mice
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Mice, Inbred ICR
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N-Methylaspartate / toxicity
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Neuroglia / drug effects
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Neuroglia / pathology
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Neuroglia / physiology
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Neurons / drug effects
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Neurons / pathology
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Neurons / physiology
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Oxygen / metabolism*
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Quercetin / pharmacology*
Substances
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Antioxidants
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Excitatory Amino Acid Agonists
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N-Methylaspartate
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Quercetin
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Glucose
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Oxygen
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Kainic Acid