Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

Shimon Sakaguchi

doi:10.1038/ni1178

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

Nat Immunol. 2005 Apr;6(4):345-52. doi: 10.1038/ni1178.

Author

Shimon Sakaguchi¹

Affiliation

¹ Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan. shimon@frontier.kyoto-u.ac.jp

PMID: 15785760
DOI: 10.1038/ni1178

Abstract

Naturally arising CD25(+)CD4(+) regulatory T cells actively maintain immunological self-tolerance. Deficiency in or dysfunction of these cells can be a cause of autoimmune disease. A reduction in their number or function can also elicit tumor immunity, whereas their antigen-specific population expansion can establish transplantation tolerance. They are therefore a good target for designing ways to induce or abrogate immunological tolerance to self and non-self antigens.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antigens, CD
Antigens, Differentiation / immunology
Autoimmune Diseases / immunology
CD4 Antigens / immunology*
CTLA-4 Antigen
DNA-Binding Proteins / immunology*
Forkhead Transcription Factors
Humans
Lymphocyte Activation
Neoplasms / immunology
Receptors, Interleukin-2 / immunology*
Self Tolerance / immunology*
T-Lymphocytes / immunology*
Thymus Gland / immunology
Transplantation Immunology

Substances

Antigens, CD
Antigens, Differentiation
CD4 Antigens
CTLA-4 Antigen
CTLA4 protein, human
DNA-Binding Proteins
FOXP3 protein, human
Forkhead Transcription Factors
Receptors, Interleukin-2