Abstract
In the present investigation, a series of new 4[(3-substituted-1H-pyrazol-4-yl)methyleneamino]-5-substituted-2-[(4-methylpiperzine-1-yl)methyl]-2H-1,2,4-triazole-3(4H)-thiones (4) were synthesized by the aminomethylation of 4-(3-substituted-1H-pyrazol-3-yl)methyleneamino-5-substituted-4H-1,2,4-triazole-3-thiols (3) with formaldehyde and N-methylpiperzine. These newly synthesized Schiff and Mannich bases were characterized by IR, (1)H NMR, mass spectral data and elemental analyses. These compounds were screened for their antibacterial and antifungal activity. Some of the compounds were found to exhibit significant antimicrobial activity.
MeSH terms
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Anti-Infective Agents / chemical synthesis
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Anti-Infective Agents / chemistry*
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Anti-Infective Agents / pharmacology*
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Antifungal Agents / chemical synthesis
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology
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Bacteria / drug effects
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Candida albicans / drug effects
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Mannich Bases / chemical synthesis
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Mannich Bases / chemistry*
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Mannich Bases / pharmacology*
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Microbial Sensitivity Tests
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Structure-Activity Relationship
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Triazoles / chemical synthesis
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Triazoles / chemistry*
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Triazoles / pharmacology*
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Antifungal Agents
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Mannich Bases
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Triazoles
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1,2,4-triazole