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Biosynthesis of polyketides by trans-AT polyketide synthases

Nat Prod Rep. 2010 Jul;27(7):996-1047. doi: 10.1039/b816430b. Epub 2010 May 12.

Abstract

This review discusses the biosynthesis of natural products that are generated by trans-AT polyketide synthases, a family of catalytically versatile enzymes that have recently been recognized as one of the major group of proteins involved in the production of bioactive polyketides. 436 references are cited.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biological Products / biosynthesis*
  • Biological Products / chemistry
  • Lactones / chemical synthesis
  • Macrolides* / chemistry
  • Macrolides* / metabolism
  • Molecular Structure
  • Polyketide Synthases / metabolism*
  • Stereoisomerism

Substances

  • Biological Products
  • Lactones
  • Macrolides
  • Polyketide Synthases
  • myxovirescin A