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Pulmonary edema and hydrothorax in swine produced by fumonisin B1, a toxic metabolite of Fusarium moniliforme

J Vet Diagn Invest. 1990 Jul;2(3):217-21. doi: 10.1177/104063879000200312.

Abstract

Pulmonary edema and hydrothorax were observed in mature swine that died approximately 5 days after consuming corn screenings. These postmortem observations were reproduced in younger swine (16-24 kg) that died within 1 week when fed the corn screenings under experimental conditions. Additionally, pulmonary edema and hydrothorax occurred in a pig (7.1 kg) that died after receiving 4 daily intravenous injections of fumonisin B1. A fungus was isolated from the corn screenings that is identical to Fusarium moniliforme MRC-826 in colony morphology and under microscopic examination.

MeSH terms

  • Animal Feed / analysis
  • Animal Feed / poisoning*
  • Animals
  • Chromatography, High Pressure Liquid
  • Food Microbiology
  • Fumonisins*
  • Fusarium / isolation & purification
  • Hydrothorax / chemically induced
  • Hydrothorax / pathology
  • Hydrothorax / veterinary*
  • Liver / pathology
  • Lung / pathology
  • Mycotoxins / analysis
  • Mycotoxins / poisoning*
  • Pancreas / pathology
  • Pulmonary Edema / chemically induced
  • Pulmonary Edema / pathology
  • Pulmonary Edema / veterinary*
  • Swine
  • Swine Diseases / chemically induced*
  • Swine Diseases / pathology
  • Zea mays

Substances

  • Fumonisins
  • Mycotoxins
  • fumonisin B1