Localized Neuron Stimulation with Organic Electrochemical Transistors on Delaminating Depth Probes

Adam Williamson; Marc Ferro; Pierre Leleux; Esma Ismailova; Attila Kaszas; Thomas Doublet; Pascale Quilichini; Jonathan Rivnay; Balázs Rózsa; Gergely Katona; Christophe Bernard; George G Malliaras

doi:10.1002/adma.201500218

Localized Neuron Stimulation with Organic Electrochemical Transistors on Delaminating Depth Probes

Adv Mater. 2015 Aug;27(30):4405-4410. doi: 10.1002/adma.201500218. Epub 2015 Jun 30.

Authors

Affiliations

¹ Aix Marseille Université, INS, 13005 Marseille, France, Inserm, UMR_S 1106, 13005, Marseille, France.
² Department of Bioelectronics, Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC, 13541, Gardanne, France.
³ Microvitae Technologies, Hôtel Technologique, Europarc Sainte Victoire Bât 6 Route de Valbrillant, 13590, Meyreuil, France.
⁴ Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony Str. 43, H-1083, Budapest, Hungary.
⁵ The Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Prater Str. 50, H-1083, Budapest, Hungary.

PMID: 26129730
DOI: 10.1002/adma.201500218

Abstract

Organic electrochemical transistors are integrated on depth probes to achieve localized electrical stimulation of neurons. The probes feature a mechanical delamination process which leaves only a 4 μm thick film with embedded transistors inside the brain. This considerably reduces probe invasiveness and correspondingly improves future brain-machine interfaces.

Keywords: PEDOT:PSS; electrical stimulation; organic bioelectronics; organic transistors.