The Metabolic Syndrome and Its Influence on Nonalcoholic Steatohepatitis

Pushpjeet Kanwar; Kris V Kowdley

doi:10.1016/j.cld.2015.10.002

The Metabolic Syndrome and Its Influence on Nonalcoholic Steatohepatitis

Clin Liver Dis. 2016 May;20(2):225-43. doi: 10.1016/j.cld.2015.10.002. Epub 2015 Dec 14.

Authors

Pushpjeet Kanwar¹, Kris V Kowdley²

Affiliations

¹ Department of Gastroenterology and Hepatology, New York Methodist Hospital, 506, 6th Street, Brooklyn, NY 11215, USA.
² Department of Transplant Hepatology, Swedish Medical Center, 1101, Madison Street, Suite 200, Seattle, WA 98104, USA. Electronic address: kris.kowdley@swedish.org.

PMID: 27063266
DOI: 10.1016/j.cld.2015.10.002

Abstract

Nonalcoholic steatohepatitis (NASH) and the metabolic syndrome (MetS) are highly prevalent in the Western population. Their pathogenesis is closely linked to insulin resistance, which serves as a therapeutic target for the management of these conditions. This review article reviews the research supporting the influence of MetS on NASH and includes studies supporting their similar epidemiology, pathogenesis, and treatment.

Keywords: Hepatocellular carcinoma; Metabolic syndrome; NAFLD; Nonalcoholic steatohepatitis; Risk factors.

Publication types

Review

MeSH terms

Adipokines / metabolism
Comorbidity
Humans
Insulin Resistance
Metabolic Syndrome / epidemiology*
Metabolic Syndrome / genetics
Metabolic Syndrome / physiopathology*
Metabolic Syndrome / therapy
Non-alcoholic Fatty Liver Disease / epidemiology*
Non-alcoholic Fatty Liver Disease / genetics
Non-alcoholic Fatty Liver Disease / physiopathology*
Non-alcoholic Fatty Liver Disease / therapy
Risk Factors

Substances

Adipokines