A hydrothermal route to multicolor luminescent carbon dots from adenosine disodium triphosphate for bioimaging

Ming Zhang; Cheng Chi; Ping Yuan; Yutian Su; Maoni Shao; Ninglin Zhou

doi:10.1016/j.msec.2017.03.144

A hydrothermal route to multicolor luminescent carbon dots from adenosine disodium triphosphate for bioimaging

Mater Sci Eng C Mater Biol Appl. 2017 Jul 1:76:1146-1153. doi: 10.1016/j.msec.2017.03.144. Epub 2017 Mar 21.

Authors

Ming Zhang¹, Cheng Chi¹, Ping Yuan¹, Yutian Su¹, Maoni Shao¹, Ninglin Zhou²

Affiliations

¹ Jiangsu Collaborative Innovation Center for biological functional materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China; Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Engineering Research Center for Biomedical Function Materials, Nanjing 210023, China.
² Jiangsu Collaborative Innovation Center for biological functional materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China; Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Engineering Research Center for Biomedical Function Materials, Nanjing 210023, China; Nanjing Zhou Ninglin Advanced Materials Technology Company Limited, Nanjing 211505, China. Electronic address: zhouninglin@njnu.edu.cn.

PMID: 28482480
DOI: 10.1016/j.msec.2017.03.144

Abstract

In this work, phosphor and nitrogen co-doped carbon dots (N-P-doped CDs) were developed for bioimaging. The as-synthesized N-P-doped CDs emit a bright blue coloured fluorescence after exposure to a 365nm UV-lamp illumination. It is also demonstrated that the fluorescence of CDs is resistant to the interference of metal ions, saline solution, and high ionic strength environments. The bright fluorescence nature of the N-P-doped CDs has proven them to be excellent probes for cellular imaging. And this guess is further confirmed by using a laser scanning confocal microscope (LSCM). The viability study was carried out by MTT assay, suggesting the high biocompatibility of N-P-doped CDs. The results demonstrated that N-P-doped CDs may be considered as a safe material for bio-imaging and drug delivery in cancer cells.

Keywords: Biocompatibility; Bioimaging; Cancer therapy; Drug delivery.

MeSH terms

Adenosine
Adenosine Triphosphate
Carbon / chemistry*
Color
Polyphosphates
Quantum Dots

Substances

Polyphosphates
Carbon
Adenosine Triphosphate
Adenosine
triphosphoric acid