Abstract
The apolipoprotein E type 4 allele (APOE-epsilon 4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE-epsilon 4 alleles in 42 families with late onset AD. Thus APOE-epsilon 4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE-epsilon 4 was virtually sufficient to cause AD by age 80.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aged
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Aged, 80 and over
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Aging
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Alleles*
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Alzheimer Disease / genetics*
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Alzheimer Disease / metabolism
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Alzheimer Disease / mortality
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Amyloid beta-Peptides / metabolism
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Apolipoprotein E4
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Apolipoproteins E / genetics*
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Apolipoproteins E / physiology
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Female
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Gene Frequency*
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Genotype
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Homozygote
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Humans
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Linkage Disequilibrium
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Male
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Risk Factors
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Survival Rate
Substances
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Amyloid beta-Peptides
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Apolipoprotein E4
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Apolipoproteins E