Funded by a grant from the National Institute of General Medical Sciences of the National Institutes of Health (Grant ID: P41GM109824).
Welcome to the NCDIR!
The National Center for Dynamic Interactome Research (NCDIR) is a Biotechnology Resource Center funded by the NIH to address the urgent need for technologies that can rapidly, reliably, and routinely reveal, represent, and interpret dynamic cellular interactomes. We work in collaboration with a diverse community of researchers and disseminate these technologies to empower others in their studies. We are four labs across the USA at the forefront of methodological and technology development in the general area of molecular cell biology. Welcome and explore!
2023: The NCDIR's Prof. Michael Rout will present a public lecture on November 27th as part of Columbia University's 'Frontier's of Science Lecture Series'. Click for details!
Sep 2023: NCDIR's Michael Rout was invited to speak about the Center's work on nanobodies at the single domain meeting in Paris!
September 22nd, 2023 – Research Spotlight!
New Publication!
Read more about the latest from the NCDIR: Implications of a multi scale structure of the yeast nuclear pore complex.
September 13th, 2023 – Research Spotlight!
New Publication!
Read the latest about nanobodies in “Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker”
September 5th, 2023 – Research Spotlight!
New Publication!
Nuclear pore complexes mediate subtelomeric gene silencing by regulating PCNA levels on chromatin. Read more.
February 21st, 2023 – Research Spotlight!
New Publication!
NCDIR scientists contributed to screening and providing key information in capturing the the SARS-CoV-2 replication transcription complex (RTC) bound to either its natural substrate or with the antiviral remdesivir yielding insights into how the drug works.
January 12th, 2023 – Research Spotlight!
New publication!
A quantitative map of the nuclear pore assembly reveals two distinct mechanisms. Read more here!
October 30th, 2022 – Research Spotlight
New publication!
Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality. Read more here
Integrative Modeling Platform
The Integrative Modeling Platform (IMP) allows comprehensive structural characterization of biomolecules ranging from small molecules to massive macromolecular complexes. IMP provides an open source C++ and Python toolbox for solving complex modeling problems, and a number of applications for tackling some common problems in a user-friendly way.
Nanobodies
The NCDIR is actively optimizing the pipeline for the production of nanobodies, highly interesting naturally occurring antibody variants isolated from Camelids. These 15 kDa antibody fragments are the topic of intense research as a tool for basic and clinical research, diagnostics, and therapeutics.
Clone database
The clone database was developed to house all the clones and strains used in the development of the NCDIR’s TR&D, DBP and collaboration and service projects. Many of these clones and strains are available to you upon request.