The synthesis and characterization of a small series of cyclic triimidazole derivatives functionalized with methylated pyridine or guanidine moieties is reported. These compounds were tested for their ability to bind to G-quadruplexes from both telomeric and oncogene promoter sequences. Some of them exhibited high affinity and effective G-quadruplex-stabilizing properties. Overall, these compounds may represent useful leads for developing more potent and selective analogues
Cyclic Triimidazoles as Stabilizers for Gene Promoter and Human Telomeric DNA G‐Quadruplexes / D. Malpicci, S. Andolina, S. Di Ciolo, E. Lucenti, E. Cariati, S. Marzano, B. Pagano, J. Amato, A. Randazzo, C. Giannini. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - 2022:35(2022 Sep 20), pp. e202200718.1-e202200718.9. [10.1002/ejoc.202200718]
Cyclic Triimidazoles as Stabilizers for Gene Promoter and Human Telomeric DNA G‐Quadruplexes
D. MalpicciPrimo
;E. Lucenti;E. Cariati;C. Giannini
Ultimo
2022
Abstract
The synthesis and characterization of a small series of cyclic triimidazole derivatives functionalized with methylated pyridine or guanidine moieties is reported. These compounds were tested for their ability to bind to G-quadruplexes from both telomeric and oncogene promoter sequences. Some of them exhibited high affinity and effective G-quadruplex-stabilizing properties. Overall, these compounds may represent useful leads for developing more potent and selective analogues
| File | Dimensione | Formato | |
|---|---|---|---|
|
Eur J Org Chem - 2022 - Malpicci - Cyclic Triimidazoles as Stabilizers for Gene Promoter and Human Telomeric DNA.pdf
accesso aperto
Tipologia:
Publisher's version/PDF
Dimensione
4.4 MB
Formato
Adobe PDF
|
4.4 MB | Adobe PDF | Visualizza/Apri |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
