Objective: To evaluate the incidence of symptomatic patent ductus arteriosus (PDA) in preterm inf... more Objective: To evaluate the incidence of symptomatic patent ductus arteriosus (PDA) in preterm infants, and the results of the intravenous indomethacine treatment and surgery. Methods: Among 394 preterm infants (<37 weeks), symptomatic PDA was diagnosed by echocardiography in 51 babies and they were examined retrospectively. All infants were managed conservatively and then IV indomethacine was given to non-responders (n=30). Surgical closure was performed in 12 babies. Results: The incidence of symptomatic PDA in preterm infants was 12.9%: median age: 3 days, mean birth weight: 1434+/-540 g (540-2900g) and mean gestational age (GA) 30.9+/-3.3 weeks (23-37 weeks). With indomethacine, ductal closure was achieved in 70% infants. Early clinical improvement was observed in all cases that underwent surgery and most of them had a low birth weight (<1500 g) and an early gestational age (<32 weeks). None of them died due to operation. Conclusion: The incidence of symptomatic PDA is high in preterm infants. Treatment with indomethacine improves ductal closure and is associated with few reversible adverse effects. In the other hand, early clinical improvement and high success rate were achieved after surgery. If indomethacine fails to achieve ductal closure, decision of surgery must be made immediately.
Behcet’s disease is a multi-systemic inflammatory disease with a clinical spectrum as a triple co... more Behcet’s disease is a multi-systemic inflammatory disease with a clinical spectrum as a triple complex of recurrent oral, genital ulcers, and uveitis. Cardiac involvement in patients with Behcet’s disease is extremely rare and often associated with poor prognosis. Behcet’s disease should be considered in the differential diagnosis of right ventricular mass especially in young adults, even there is no typical clinical features of Behcet’s disease. In this case, a 12-year-old girl who admitted with chest pain and haemoptysis and then was diagnosed with intracardiac thrombus related to Behcet’s disease during follow-up was described.
Objective: Some cardiovascular side effects can be seen in patients receiving methylphenidate tre... more Objective: Some cardiovascular side effects can be seen in patients receiving methylphenidate treatment with a diagnosis of attention deficit and hyperactivity disorder (ADHD), although not frequent. There are few studies in the literature conducted in these patients about this issue. We aimed to investigate the early effects of methylphenidate on the cardiovascular system in children with ADHD in this study. Material and Methods: We analyzed 141 patients receiving methylphenidate treatment for ADHD in the pediatric psychiatry clinic of our hospital between May 2011 and May 2012. We retrospectively evaluated the demographic characteristics, heart rate, systolic and diastolic blood pressures, QTc duration at electrocardiogram (ECG) and 24-hour rhythm Holter results of thirty patients who had cardiovascular symptoms in the first month of treatment. Results: We evaluated a total of 30 patients (8 female and 22 male) with a mean age of 10±3 years for females and 9±2.2 years for males....
We presented a four-year-old girl with Tay-Sachs disease who had thrombus in the right atrium. Th... more We presented a four-year-old girl with Tay-Sachs disease who had thrombus in the right atrium. The patient was admitted to hospital with cardiopulmonary arrest and aspiration pneumonia was diagnosed. Intracardiac thrombus was detected during rutine echocardiographic examination. There was no underlying genetic prothrombotic predisposition in this patient. The guidelines of treatment for intracardiac thrombus in children are lacking in the literature andthe experience in managing these patients is limited. We aimed to to discuss the treatment approaches to intracardiac thrombi and to emphasize that, development of intracardiac thrombus is common in critically ill children and can be treated successfully by non-invasive anticoagulation with heparin.
The aim of this study is to evaluate the changes in myocardial functions in children who underwen... more The aim of this study is to evaluate the changes in myocardial functions in children who underwent haematopoietic stem cell transplantation along with associated chemotherapy. Additionally, we evaluated the effect of baseline echocardiographic parameters on mortality. We evaluated 39 patients (mean age 7.4 years) who underwent haematopoietic stem cell transplantation owing to non-malignant disease. The control group included 39 healthy children who had normal cardiac findings. The myocardial functions were evaluated in all subjects by conventional echocardiography and tissue Doppler echocardiography before haematopoietic stem cell transplantation and in the 1st, 3rd, 6th, and 12th month after haematopoietic stem cell transplantation. All patients had normal left ventricular ejection fraction before haematopoietic stem cell transplantation, except one case. Before haematopoietic stem cell transplantation, the patient group had significantly greater mean pulmonary artery pressure and ...
Objective: To evaluate the incidence of symptomatic patent ductus arteriosus (PDA) in preterm inf... more Objective: To evaluate the incidence of symptomatic patent ductus arteriosus (PDA) in preterm infants, and the results of the intravenous indomethacine treatment and surgery. Methods: Among 394 preterm infants (<37 weeks), symptomatic PDA was diagnosed by echocardiography in 51 babies and they were examined retrospectively. All infants were managed conservatively and then IV indomethacine was given to non-responders (n=30). Surgical closure was performed in 12 babies. Results: The incidence of symptomatic PDA in preterm infants was 12.9%: median age: 3 days, mean birth weight: 1434+/-540 g (540-2900g) and mean gestational age (GA) 30.9+/-3.3 weeks (23-37 weeks). With indomethacine, ductal closure was achieved in 70% infants. Early clinical improvement was observed in all cases that underwent surgery and most of them had a low birth weight (<1500 g) and an early gestational age (<32 weeks). None of them died due to operation. Conclusion: The incidence of symptomatic PDA is high in preterm infants. Treatment with indomethacine improves ductal closure and is associated with few reversible adverse effects. In the other hand, early clinical improvement and high success rate were achieved after surgery. If indomethacine fails to achieve ductal closure, decision of surgery must be made immediately.
Behcet’s disease is a multi-systemic inflammatory disease with a clinical spectrum as a triple co... more Behcet’s disease is a multi-systemic inflammatory disease with a clinical spectrum as a triple complex of recurrent oral, genital ulcers, and uveitis. Cardiac involvement in patients with Behcet’s disease is extremely rare and often associated with poor prognosis. Behcet’s disease should be considered in the differential diagnosis of right ventricular mass especially in young adults, even there is no typical clinical features of Behcet’s disease. In this case, a 12-year-old girl who admitted with chest pain and haemoptysis and then was diagnosed with intracardiac thrombus related to Behcet’s disease during follow-up was described.
Objective: Some cardiovascular side effects can be seen in patients receiving methylphenidate tre... more Objective: Some cardiovascular side effects can be seen in patients receiving methylphenidate treatment with a diagnosis of attention deficit and hyperactivity disorder (ADHD), although not frequent. There are few studies in the literature conducted in these patients about this issue. We aimed to investigate the early effects of methylphenidate on the cardiovascular system in children with ADHD in this study. Material and Methods: We analyzed 141 patients receiving methylphenidate treatment for ADHD in the pediatric psychiatry clinic of our hospital between May 2011 and May 2012. We retrospectively evaluated the demographic characteristics, heart rate, systolic and diastolic blood pressures, QTc duration at electrocardiogram (ECG) and 24-hour rhythm Holter results of thirty patients who had cardiovascular symptoms in the first month of treatment. Results: We evaluated a total of 30 patients (8 female and 22 male) with a mean age of 10±3 years for females and 9±2.2 years for males....
We presented a four-year-old girl with Tay-Sachs disease who had thrombus in the right atrium. Th... more We presented a four-year-old girl with Tay-Sachs disease who had thrombus in the right atrium. The patient was admitted to hospital with cardiopulmonary arrest and aspiration pneumonia was diagnosed. Intracardiac thrombus was detected during rutine echocardiographic examination. There was no underlying genetic prothrombotic predisposition in this patient. The guidelines of treatment for intracardiac thrombus in children are lacking in the literature andthe experience in managing these patients is limited. We aimed to to discuss the treatment approaches to intracardiac thrombi and to emphasize that, development of intracardiac thrombus is common in critically ill children and can be treated successfully by non-invasive anticoagulation with heparin.
The aim of this study is to evaluate the changes in myocardial functions in children who underwen... more The aim of this study is to evaluate the changes in myocardial functions in children who underwent haematopoietic stem cell transplantation along with associated chemotherapy. Additionally, we evaluated the effect of baseline echocardiographic parameters on mortality. We evaluated 39 patients (mean age 7.4 years) who underwent haematopoietic stem cell transplantation owing to non-malignant disease. The control group included 39 healthy children who had normal cardiac findings. The myocardial functions were evaluated in all subjects by conventional echocardiography and tissue Doppler echocardiography before haematopoietic stem cell transplantation and in the 1st, 3rd, 6th, and 12th month after haematopoietic stem cell transplantation. All patients had normal left ventricular ejection fraction before haematopoietic stem cell transplantation, except one case. Before haematopoietic stem cell transplantation, the patient group had significantly greater mean pulmonary artery pressure and ...
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Papers by Filiz Ekici