International Journal of Computer Integrated Manufacturing, 2012
Nowadays, companies strive to survive in a competitive global environment. Reduction of product d... more Nowadays, companies strive to survive in a competitive global environment. Reduction of product development cycle plays a major role in market penetration and cost reduction. To speed up product development/modifications, it is suggested to adopt a collaborative product development approach. Collaborative design and manufacture requires an integrated platform to support related CAx product data models. To integrate CAx product data, a number of solutions are proposed. The most successful solution is adopting the STandard for Exchange of Product Data (STEP). In the course of the STEP standard structure and procedure development, two approaches can be recognised: classical and modular. The classical STEP standard has some shortcomings that slow down its implementation in collaborative data exchange. It is believed that the modular architecture of the STEP standard could improve these shortcomings. In this paper, the STEP modular architecture is adopted and a platform named LAYMOD to fulfil the requirements of CAx product data integration and collaboration is proposed. The platform is a layered platform to enable global collaboration and data integration among different CAx software packages. The architecture and procedures of LAYMOD platform are discussed thoroughly in a case study. The results of adopting the STEP modular architecture in the platform show that the LAYMOD fulfils CAx collaboration and product data integration, overcomes the classical STEP standard shortcomings, reduces the high cost and lengthy time of application protocols' (APs) implementation and eliminates duplication and repeated documentation of the same data entries in different APs.
Disease patterns and manifestations may vary among different populations and change over time. Th... more Disease patterns and manifestations may vary among different populations and change over time. The purpose of our study was to define the demographic, clinical, roentgenologic, and laboratory findings in a recent cohort of psoriatic arthritis patients followed up in rheumatology clinics in northern Israel. We conducted a cross-sectional study of 149 psoriatic arthritis patients. Demographic, clinical, laboratory, and radiological data, with emphasis on the pattern of arthritis, treatment regimens, and co-morbidities were obtained from patient interviews and rheumatology file reviews. The mean age of our patients was 58.2, with a female preponderance (57.3%). Skin involvement preceded the arthritis or was diagnosed simultaneously in 90.1% of cases. The most common joint involvement was an RA-like arthritis (49.7% of the patients) correlating positively with age, female gender, and disease duration. Dactylitis and nail involvement were observed in 33.6 and 36.2% of the patients, respectively. Radiographic bone erosions were noted in a third of the patients, correlating with DIP and RA-like arthritis patterns. Most patients were treated with methotrexate (73.8%) and a combination therapy (41.4%). An increased incidence of hypertension, hyperlipidemia, and diabetes mellitus was noted in our cohort compared to the general Israeli population. Our survey, the first of its kind conducted in Israel, noted a relative increase in the polyarticular manifestation of PsA and a decrease in spondyloarthropathy, compared to historic series, with more aggressive disease found in women above the age of sixty. These findings are in line with recent surveys.
Plasma anandamide (AEA) levels fluctuate throughout the menstrual cycle and in early pregnancy in... more Plasma anandamide (AEA) levels fluctuate throughout the menstrual cycle and in early pregnancy in a pattern suggesting its involvement in implantation and early pregnancy maintenance through mechanisms that might involve its binding to cannabinoid receptors CB1 and CB2. Plasma AEA levels are maintained by the actions of the enzymes fatty acid amide hydrolase (FAAH) and N-acylphosphatidylethanolamine-phospholipase D (NAPE-PLD). All of these component parts of the ‘endocannabinoid system’ have been demonstrated in rodent but not in human uteri. This study aimed to demonstrate the presence of the endocannabinoid system in the human uterus and catalogue its modulation. Immunohistochemical techniques were employed to localise and determine the distribution of immunoreactive CB1, CB2, FAAH, and NAPE-PLD in well-characterised menstrual cycle biopsy samples. Immunoreactive CB1 and CB2 were widely distributed throughout the uterine tissue. In the myometrium and endometrium, smooth muscle cells were immunoreactive, although the vascular smooth muscle cells in both tissues were more so. In the endometrium, CB1 and CB2 immunoreactivity was primarily restricted to the glandular epithelium and expression was unrelated to the phase of the cycle. FAAH immunoreactivity in the endometrium was highest in the mid-proliferative gland and mid-secretory stroma, whilst NAPE-PLD immunoreactivity was down-regulated in the secretory epithelial gland compared to the proliferative epithelial gland and unaffected in the stroma. These data indicate that elements of the ‘endocannabinoid system’ coexist in many cell types within the uterus and may provide insight into the sites of action of endogenous and exogenous cannabinoids during endometrial transformation.
In this paper I have shown that the interaction of morphology and syntax in an OT grammar account... more In this paper I have shown that the interaction of morphology and syntax in an OT grammar accounts for a wide range of facts about the order of subject agreement affixes, both crosslinguistically and in the grammar of single languages. It remains to be seen how this type of account extends to other affix types. Trommer (2002a) shows that the ordering of fused subject/object agreement also follows an alignment pattern and discusses some tentative results on object agreement pointing in the same direction. Hyman (2001) shows that affixes involved in Bantu grammatical-function changing processes (causative, passive, etc.) also show the interplay of syntactic/semantic constraints with purely morphological factors.30 Interestingly, there is independent morphological evidence that at least voice affixes form a natural class with agreement and are inserted ‘late’ after syntax (Embick 1998). This gives further support to the claim that the asymmetry between Tense/Aspect and Agreement is due to the more principled difference between syntactic and morphological affixes.
A 67-year-old man presented with a history of lymphadenopathy, fevers and separate skin eruptions... more A 67-year-old man presented with a history of lymphadenopathy, fevers and separate skin eruptions of erythrodermic spongiotic dermatitis initially and subsequent toxic epidermal necrolysis. Initial lymph node biopsies showed non-specific granulomatous changes, and skin biopsies and bone marrow aspirate were not diagnostic. His toxic epidermal necrolysis responded well to 3 days of intravenous immunoglobulin. The patient was discharged from hospital and reviewed regularly as an outpatient. Due to persisting lymphadenopathy, further lymph node biopsy led to the diagnosis of angioimmunoblastic T-cell lymphoma, a rare form of peripheral T-cell lymphoma with a poor prognosis. At the time of diagnosis his condition deteriorated rapidly and he died soon after.
International Journal of Computer Integrated Manufacturing, 2012
Nowadays, companies strive to survive in a competitive global environment. Reduction of product d... more Nowadays, companies strive to survive in a competitive global environment. Reduction of product development cycle plays a major role in market penetration and cost reduction. To speed up product development/modifications, it is suggested to adopt a collaborative product development approach. Collaborative design and manufacture requires an integrated platform to support related CAx product data models. To integrate CAx product data, a number of solutions are proposed. The most successful solution is adopting the STandard for Exchange of Product Data (STEP). In the course of the STEP standard structure and procedure development, two approaches can be recognised: classical and modular. The classical STEP standard has some shortcomings that slow down its implementation in collaborative data exchange. It is believed that the modular architecture of the STEP standard could improve these shortcomings. In this paper, the STEP modular architecture is adopted and a platform named LAYMOD to fulfil the requirements of CAx product data integration and collaboration is proposed. The platform is a layered platform to enable global collaboration and data integration among different CAx software packages. The architecture and procedures of LAYMOD platform are discussed thoroughly in a case study. The results of adopting the STEP modular architecture in the platform show that the LAYMOD fulfils CAx collaboration and product data integration, overcomes the classical STEP standard shortcomings, reduces the high cost and lengthy time of application protocols' (APs) implementation and eliminates duplication and repeated documentation of the same data entries in different APs.
Disease patterns and manifestations may vary among different populations and change over time. Th... more Disease patterns and manifestations may vary among different populations and change over time. The purpose of our study was to define the demographic, clinical, roentgenologic, and laboratory findings in a recent cohort of psoriatic arthritis patients followed up in rheumatology clinics in northern Israel. We conducted a cross-sectional study of 149 psoriatic arthritis patients. Demographic, clinical, laboratory, and radiological data, with emphasis on the pattern of arthritis, treatment regimens, and co-morbidities were obtained from patient interviews and rheumatology file reviews. The mean age of our patients was 58.2, with a female preponderance (57.3%). Skin involvement preceded the arthritis or was diagnosed simultaneously in 90.1% of cases. The most common joint involvement was an RA-like arthritis (49.7% of the patients) correlating positively with age, female gender, and disease duration. Dactylitis and nail involvement were observed in 33.6 and 36.2% of the patients, respectively. Radiographic bone erosions were noted in a third of the patients, correlating with DIP and RA-like arthritis patterns. Most patients were treated with methotrexate (73.8%) and a combination therapy (41.4%). An increased incidence of hypertension, hyperlipidemia, and diabetes mellitus was noted in our cohort compared to the general Israeli population. Our survey, the first of its kind conducted in Israel, noted a relative increase in the polyarticular manifestation of PsA and a decrease in spondyloarthropathy, compared to historic series, with more aggressive disease found in women above the age of sixty. These findings are in line with recent surveys.
Plasma anandamide (AEA) levels fluctuate throughout the menstrual cycle and in early pregnancy in... more Plasma anandamide (AEA) levels fluctuate throughout the menstrual cycle and in early pregnancy in a pattern suggesting its involvement in implantation and early pregnancy maintenance through mechanisms that might involve its binding to cannabinoid receptors CB1 and CB2. Plasma AEA levels are maintained by the actions of the enzymes fatty acid amide hydrolase (FAAH) and N-acylphosphatidylethanolamine-phospholipase D (NAPE-PLD). All of these component parts of the ‘endocannabinoid system’ have been demonstrated in rodent but not in human uteri. This study aimed to demonstrate the presence of the endocannabinoid system in the human uterus and catalogue its modulation. Immunohistochemical techniques were employed to localise and determine the distribution of immunoreactive CB1, CB2, FAAH, and NAPE-PLD in well-characterised menstrual cycle biopsy samples. Immunoreactive CB1 and CB2 were widely distributed throughout the uterine tissue. In the myometrium and endometrium, smooth muscle cells were immunoreactive, although the vascular smooth muscle cells in both tissues were more so. In the endometrium, CB1 and CB2 immunoreactivity was primarily restricted to the glandular epithelium and expression was unrelated to the phase of the cycle. FAAH immunoreactivity in the endometrium was highest in the mid-proliferative gland and mid-secretory stroma, whilst NAPE-PLD immunoreactivity was down-regulated in the secretory epithelial gland compared to the proliferative epithelial gland and unaffected in the stroma. These data indicate that elements of the ‘endocannabinoid system’ coexist in many cell types within the uterus and may provide insight into the sites of action of endogenous and exogenous cannabinoids during endometrial transformation.
In this paper I have shown that the interaction of morphology and syntax in an OT grammar account... more In this paper I have shown that the interaction of morphology and syntax in an OT grammar accounts for a wide range of facts about the order of subject agreement affixes, both crosslinguistically and in the grammar of single languages. It remains to be seen how this type of account extends to other affix types. Trommer (2002a) shows that the ordering of fused subject/object agreement also follows an alignment pattern and discusses some tentative results on object agreement pointing in the same direction. Hyman (2001) shows that affixes involved in Bantu grammatical-function changing processes (causative, passive, etc.) also show the interplay of syntactic/semantic constraints with purely morphological factors.30 Interestingly, there is independent morphological evidence that at least voice affixes form a natural class with agreement and are inserted ‘late’ after syntax (Embick 1998). This gives further support to the claim that the asymmetry between Tense/Aspect and Agreement is due to the more principled difference between syntactic and morphological affixes.
A 67-year-old man presented with a history of lymphadenopathy, fevers and separate skin eruptions... more A 67-year-old man presented with a history of lymphadenopathy, fevers and separate skin eruptions of erythrodermic spongiotic dermatitis initially and subsequent toxic epidermal necrolysis. Initial lymph node biopsies showed non-specific granulomatous changes, and skin biopsies and bone marrow aspirate were not diagnostic. His toxic epidermal necrolysis responded well to 3 days of intravenous immunoglobulin. The patient was discharged from hospital and reviewed regularly as an outpatient. Due to persisting lymphadenopathy, further lymph node biopsy led to the diagnosis of angioimmunoblastic T-cell lymphoma, a rare form of peripheral T-cell lymphoma with a poor prognosis. At the time of diagnosis his condition deteriorated rapidly and he died soon after.
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