Allogeneic bone marrow or blood stem cell transplantation (BMT) represents an important therapeut... more Allogeneic bone marrow or blood stem cell transplantation (BMT) represents an important therapeutic tool for treatment of otherwise incurable malignant and nonmalignant diseases, especially acute and chronic leukemias. Until recently, myeloablative regimens were considered mandatory for effective eradication of all malignant cells of host origin. Our preclinical and ongoing clinical studies indicated that eradication of host immunohematopoietic cells, including chemoradiotherapy-resistant leukemia, could be achieved by adoptive allogeneic cell therapy with donor lymphocyte infusion following induction of host-versus-graft transplantation tolerance mediated by engraftment of donor stem cells in the course of BMT. Thus, eradication of blood cancer cells, especially in patients with chronic myeloid leukemia and less frequently in patients with other hematologic malignancies, could be frequently accomplished despite complete resistance of such tumor cells to maximally tolerated doses of...
It was determined of the effects of plant growth regulator (PGR) named the Tonifruit, on the yiel... more It was determined of the effects of plant growth regulator (PGR) named the Tonifruit, on the yield and earlines of some important eggplant (Solanum melongena L.) varieties (Topan 374, Kemer and Pala) in Tokat. The seeds of these varieties were sown to the plastic tubes in the high plastic tunnel on the date 18th March of 1989. In the flaver stage the levels of PGR as 0. 0.3. 0.6, 0.9 g/L were treated at three times with interval of 10 days. The PGR hasn’t effected the total yield, earlines, fruit size and dimenslans. At the level of 0.9 g/L high mates of the light color fruits were occured as 24% in Pala variety and 19% in Topan 374. Fruit shape of Topan 374 variety has round and the total yield of this variety was found 18.37 t/ha. The total yield of Kemer was found 15-45 t/ha and the total yield of Pala variety was found 21.11 t/ha. So that Pala variety has highest total yield which maybe recommeded the growing instead of Kemer variety In Tokat.
Allogeneic bone marrow or blood stem cell transplantation (BMT) represents an important therapeut... more Allogeneic bone marrow or blood stem cell transplantation (BMT) represents an important therapeutic tool for the treatment of an otherwise incurable broad spectrum of malignant and non-malignant diseases. Until recently, BMT was used primarily to replace a malignant, genetically abnormal or deficient immunohematopoietic compartment and therefore, highly toxic myeloablative regimens were considered mandatory for more effective eradication of all undesirable host-derived hematopoietic cells, including stem cells and their progeny. Our preclinical and ongoing clinical studies indicated that much more effective eradication of host immunohematopoietic system cells can be mediated by donor lymphocytes in the process of adoptive allogeneic cell therapy following BMT. Thus, eradication of all malignant cells, especially in patients with CML and, to a lesser extent, in patients with other hematologic malignancies can be accomplished despite complete resistance of puch tumor cells to maximall...
Over the past few decades, great strides have been made to advance the field of allogeneic hemato... more Over the past few decades, great strides have been made to advance the field of allogeneic hematopoietic stem cell transplantation. The donor immune mediated graft-vs-tumor effect that follows the procedure is now widely accepted as the most effective form cancer immunotherapy available for patients with a variety of advanced hematological malignancies. Recognition that a transplanted immune system could cure patients with treatment refractory leukemia led to the development of ;low-intensity' conditioning regimens, which have improved the safety of the procedure and broadened the application of allogeneic immunotherapy to a growing list of neoplastic diseases. Here we discuss the investigational use of allogeneic transplantation as immunotherapy for patients with metastatic, treatment-refractory solid tumors.
Since introducing dexamethasone as adjuvant therapy to antibiotics for bacterial meningitis, we h... more Since introducing dexamethasone as adjuvant therapy to antibiotics for bacterial meningitis, we have noticed an increase in the number of cases with secondary fever. Therefore, we performed a retrospective analysis of the 19 consecutive cases occurring during the last 5 years. Six patients received dexamethasone for 4 days, 5 received a 2-day course of dexamethasone and 8 received antibiotics only. The etiologic agents included: Haemophilus influenzae (in 11 patients), Streptococcus pneumoniae (in 6) and Neisseria meningitidis (in 2). Among the 11 patients receiving dexamethasone, the fever remitted within 1-5 days (average 1.7 +/- 1.2) while among the 8 patients not receiving dexamethasone the initial fever lasted 1-17 days (average 5.3 +/- 1.7) (P = 0.009). There was secondary fever without a definable clinical or bacteriological source in 9 of 11 patients receiving dexamethasone and in none of those who were treated without steroids (P < 0.001). The secondary fever among those...
SIGLEAvailable from British Library Document Supply Centre- DSC:q95/21727 / BLDSC - British Libra... more SIGLEAvailable from British Library Document Supply Centre- DSC:q95/21727 / BLDSC - British Library Document Supply CentreGBUnited Kingdo
Introduction Allogeneic bone marrow transplantation (BMT) represents the only modality for treatm... more Introduction Allogeneic bone marrow transplantation (BMT) represents the only modality for treatment of hematologic malignan-cies as well as for replacement of genetically abnormal stem cells with normal donor stem cells, thus presenting an ulti-mate treatment of choice for patients ...
Proceedings of the National Academy of Sciences of the United States of America, Nov 21, 2017
H3N2 viruses continuously acquire mutations in the hemagglutinin (HA) glycoprotein that abrogate ... more H3N2 viruses continuously acquire mutations in the hemagglutinin (HA) glycoprotein that abrogate binding of human antibodies. During the 2014-2015 influenza season, clade 3C.2a H3N2 viruses possessing a new predicted glycosylation site in antigenic site B of HA emerged, and these viruses remain prevalent today. The 2016-2017 seasonal influenza vaccine was updated to include a clade 3C.2a H3N2 strain; however, the egg-adapted version of this viral strain lacks the new putative glycosylation site. Here, we biochemically demonstrate that the HA antigenic site B of circulating clade 3C.2a viruses is glycosylated. We show that antibodies elicited in ferrets and humans exposed to the egg-adapted 2016-2017 H3N2 vaccine strain poorly neutralize a glycosylated clade 3C.2a H3N2 virus. Importantly, antibodies elicited in ferrets infected with the current circulating H3N2 viral strain (that possesses the glycosylation site) and humans vaccinated with baculovirus-expressed H3 antigens (that poss...
Allogeneic bone marrow or blood stem cell transplantation (BMT) represents an important therapeut... more Allogeneic bone marrow or blood stem cell transplantation (BMT) represents an important therapeutic tool for treatment of otherwise incurable malignant and nonmalignant diseases, especially acute and chronic leukemias. Until recently, myeloablative regimens were considered mandatory for effective eradication of all malignant cells of host origin. Our preclinical and ongoing clinical studies indicated that eradication of host immunohematopoietic cells, including chemoradiotherapy-resistant leukemia, could be achieved by adoptive allogeneic cell therapy with donor lymphocyte infusion following induction of host-versus-graft transplantation tolerance mediated by engraftment of donor stem cells in the course of BMT. Thus, eradication of blood cancer cells, especially in patients with chronic myeloid leukemia and less frequently in patients with other hematologic malignancies, could be frequently accomplished despite complete resistance of such tumor cells to maximally tolerated doses of...
It was determined of the effects of plant growth regulator (PGR) named the Tonifruit, on the yiel... more It was determined of the effects of plant growth regulator (PGR) named the Tonifruit, on the yield and earlines of some important eggplant (Solanum melongena L.) varieties (Topan 374, Kemer and Pala) in Tokat. The seeds of these varieties were sown to the plastic tubes in the high plastic tunnel on the date 18th March of 1989. In the flaver stage the levels of PGR as 0. 0.3. 0.6, 0.9 g/L were treated at three times with interval of 10 days. The PGR hasn’t effected the total yield, earlines, fruit size and dimenslans. At the level of 0.9 g/L high mates of the light color fruits were occured as 24% in Pala variety and 19% in Topan 374. Fruit shape of Topan 374 variety has round and the total yield of this variety was found 18.37 t/ha. The total yield of Kemer was found 15-45 t/ha and the total yield of Pala variety was found 21.11 t/ha. So that Pala variety has highest total yield which maybe recommeded the growing instead of Kemer variety In Tokat.
Allogeneic bone marrow or blood stem cell transplantation (BMT) represents an important therapeut... more Allogeneic bone marrow or blood stem cell transplantation (BMT) represents an important therapeutic tool for the treatment of an otherwise incurable broad spectrum of malignant and non-malignant diseases. Until recently, BMT was used primarily to replace a malignant, genetically abnormal or deficient immunohematopoietic compartment and therefore, highly toxic myeloablative regimens were considered mandatory for more effective eradication of all undesirable host-derived hematopoietic cells, including stem cells and their progeny. Our preclinical and ongoing clinical studies indicated that much more effective eradication of host immunohematopoietic system cells can be mediated by donor lymphocytes in the process of adoptive allogeneic cell therapy following BMT. Thus, eradication of all malignant cells, especially in patients with CML and, to a lesser extent, in patients with other hematologic malignancies can be accomplished despite complete resistance of puch tumor cells to maximall...
Over the past few decades, great strides have been made to advance the field of allogeneic hemato... more Over the past few decades, great strides have been made to advance the field of allogeneic hematopoietic stem cell transplantation. The donor immune mediated graft-vs-tumor effect that follows the procedure is now widely accepted as the most effective form cancer immunotherapy available for patients with a variety of advanced hematological malignancies. Recognition that a transplanted immune system could cure patients with treatment refractory leukemia led to the development of ;low-intensity' conditioning regimens, which have improved the safety of the procedure and broadened the application of allogeneic immunotherapy to a growing list of neoplastic diseases. Here we discuss the investigational use of allogeneic transplantation as immunotherapy for patients with metastatic, treatment-refractory solid tumors.
Since introducing dexamethasone as adjuvant therapy to antibiotics for bacterial meningitis, we h... more Since introducing dexamethasone as adjuvant therapy to antibiotics for bacterial meningitis, we have noticed an increase in the number of cases with secondary fever. Therefore, we performed a retrospective analysis of the 19 consecutive cases occurring during the last 5 years. Six patients received dexamethasone for 4 days, 5 received a 2-day course of dexamethasone and 8 received antibiotics only. The etiologic agents included: Haemophilus influenzae (in 11 patients), Streptococcus pneumoniae (in 6) and Neisseria meningitidis (in 2). Among the 11 patients receiving dexamethasone, the fever remitted within 1-5 days (average 1.7 +/- 1.2) while among the 8 patients not receiving dexamethasone the initial fever lasted 1-17 days (average 5.3 +/- 1.7) (P = 0.009). There was secondary fever without a definable clinical or bacteriological source in 9 of 11 patients receiving dexamethasone and in none of those who were treated without steroids (P < 0.001). The secondary fever among those...
SIGLEAvailable from British Library Document Supply Centre- DSC:q95/21727 / BLDSC - British Libra... more SIGLEAvailable from British Library Document Supply Centre- DSC:q95/21727 / BLDSC - British Library Document Supply CentreGBUnited Kingdo
Introduction Allogeneic bone marrow transplantation (BMT) represents the only modality for treatm... more Introduction Allogeneic bone marrow transplantation (BMT) represents the only modality for treatment of hematologic malignan-cies as well as for replacement of genetically abnormal stem cells with normal donor stem cells, thus presenting an ulti-mate treatment of choice for patients ...
Proceedings of the National Academy of Sciences of the United States of America, Nov 21, 2017
H3N2 viruses continuously acquire mutations in the hemagglutinin (HA) glycoprotein that abrogate ... more H3N2 viruses continuously acquire mutations in the hemagglutinin (HA) glycoprotein that abrogate binding of human antibodies. During the 2014-2015 influenza season, clade 3C.2a H3N2 viruses possessing a new predicted glycosylation site in antigenic site B of HA emerged, and these viruses remain prevalent today. The 2016-2017 seasonal influenza vaccine was updated to include a clade 3C.2a H3N2 strain; however, the egg-adapted version of this viral strain lacks the new putative glycosylation site. Here, we biochemically demonstrate that the HA antigenic site B of circulating clade 3C.2a viruses is glycosylated. We show that antibodies elicited in ferrets and humans exposed to the egg-adapted 2016-2017 H3N2 vaccine strain poorly neutralize a glycosylated clade 3C.2a H3N2 virus. Importantly, antibodies elicited in ferrets infected with the current circulating H3N2 viral strain (that possesses the glycosylation site) and humans vaccinated with baculovirus-expressed H3 antigens (that poss...
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