I am working as an Associate professor in the Department of Zoology, University of Madras. At present, i am involving in the toxicological research about the organ toxic effects of heavy metals and their chelation by phytoconstituents. I have published more than 78 international peer-reviewed papers, with a total impact factor 96. 28 and I have organized two national conferences and workshops in environmental toxicology and running one UGC Major research project in toxicology. Phone: +919842325222 Address: Assistant Professor,department of zoology Annamalai university,chidambaram,Tamilnadu-28002 India
Abstract Curcumin, a major constituent of turmeric (Curcuma longa) which has been reported to hav... more Abstract Curcumin, a major constituent of turmeric (Curcuma longa) which has been reported to have a wide spectrum of pharmacological activities. The present work was carried out to evaluate the effect of curcumin on serum hepatic marker enzymes, ...
This study was carried out to evaluate the effect of dietary vitamins C (ascorbic acid) and E (α-... more This study was carried out to evaluate the effect of dietary vitamins C (ascorbic acid) and E (α-tocopherol) on serum hepatic marker enzymes, antioxidant and lipid peroxidation status in liver of cadmium intoxicated rats. Administration of cadmium chloride (5 mg/kg body wt/day) for ...
Research & Reviews: A Journal of Toxicology, Sep 1, 2014
The aim of the study was to investigate the in vivo circulating antioxidants level such as vitami... more The aim of the study was to investigate the in vivo circulating antioxidants level such as vitamin C, vitamin E and GSH in Cadmium (Cd) induced toxic rats and the protective efficacy of naringenin via in vitro free radical scavenging assays. In this investigation cadmium chloride (5 mg/kg body weight (b.w) was administered orally (p.o) for 28 days to induce toxicity. Naringenin was pre-administered orally (50 mg/kg body weight) for 28 days with cadmium chloride. The toxic effect of cadmium was indicated by significantly decreased activities of non-enzymatic antioxidants like reduced glutathione, vitamin C and vitamin E. Treatment with naringenin exhibited a significant (P < 0.05) increase in Cd-induced rats. The free radical scavenging properties of naringenin were investigated with different in vitro methods such as 2, 2 ¢ -diphenyl-1-picrylhydrazyl radical (DPPH•), 2,2’-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) radical (ABTS•+), hydroxyl radical, superoxide anion scavenging activity and reducing power. In addition to that ascorbic acid, butylated hydroxyl toluene was used as the reference antioxidant radical scavenger compounds. Among the different concentration, 500 μM of naringenin had significantly effective compared to other concentration in all in vitro assay. Based on these findings naringenin possess potent in vivo and in vitro antioxidant efficacy and also effective free radical scavenger, augmenting its therapeutic value.
Fluoride (Fl) exposure engenders neurodegeneration in the brain. The Neuroprotective role of EGCG... more Fluoride (Fl) exposure engenders neurodegeneration in the brain. The Neuroprotective role of EGCG against Fl induced neurotoxicity in rat hippocampus has not yet been explored so far. In this present exploration we focused to witness whether EGCG (40mg/kg) prevents the Fl induced oxidative stress in the brain of rats with special emphasis on hippocampus. Fl (25mg/kg) intoxication for 4 weeks shows decreased neurotransmitters (AChE, NP, DA and 5-HT) in the brain. The oxidative stress markers (ROS, TBARS, NO and PC) were significantly increased with decreased enzymatic (SOD, CAT, GPx, GR, GST, and G6PD) and non-enzymatic antioxidants (GSH, TSH and Vit.C) in Fl intoxicated rat hippocampus. Moreover, Fl intoxicated rats showed an intrinsic and extrinsic pathway mediated apoptosis in the hippocampus of rats. Fl significantly increased the DNA damage as evidenced by increased DNA fragmentation. Furthermore, the toxic impact of Fl on hippocampus was also proved by the immunohistochemical, histological and ultra-structural studies. Pre-administration of EGCG significantly protected the rat brain and hippocampus against Fl ROS by its strong antioxidant and free radical scavenging ability.
Abstract Heavy metal pollutants are generally discharged in the aquatic environment as a result o... more Abstract Heavy metal pollutants are generally discharged in the aquatic environment as a result of industrial processes and are causing major problems in the food chain. Pollution due to heavy metals is of serious concern and among them cadmium deserves special ...
Endosulfan is an important hepatotoxic agent that generates free oxygen radicals in liver and the... more Endosulfan is an important hepatotoxic agent that generates free oxygen radicals in liver and the incidence of toxic injury to the liver tissue in relation to its widespread has been reported. Bamboo is rich in phenolic components which possess various bioactivities and bamboo seed extract was found to have antioxidative properties. Hence, the present study has been designed to assess the protective role of bamboo seed extract against endosulfan induced hepatotoxicity in rat as the endosulfan can persistent to environment where its attributes lead to bioconcentration and biomagnification in certain food chains. For experiments male albino rats weighing 170–190 g were randomly selected and divided into four groups consisting of six rats in each group. The hepatotoxic effects of oral administration of endosulfan (15 mg/kg B.W) and hepato-protective effect of co-administration of bamboo seed extract (90 mg/kg B.W) with endosulfan daily for 10 days, were investigated in rats using serum...
ABSTRACT Arsenic (As) is a metalloid listed in group Va of the periodic chart. It exists in natur... more ABSTRACT Arsenic (As) is a metalloid listed in group Va of the periodic chart. It exists in nature in the oxidation states +V (arsenate), +III (arsenite), 0 (arsenic) and −III (arsine). In the aqueous environment inorganic arsenic appears commonly in the oxidation states +V and +III as arsenous acid (As (III)), arsenic acid (As (V)), and their salts. Chronic and acute exposures of arsenic leads to cancer, cardiovascular disease (hypertension and atherosclerosis), neurological disorders, gastrointestinal disturbances, liver disease and renal disease, reproductive health effects, dermal changes and other health disorders and also affects the antioxidant system in the body. Furthermore, reactive oxygen species (ROS)-mediated oxidative damage is a common denominator in arsenic pathogenesis. Formation of free radical such as superoxide radical due to cascade mechanism, combined with glutathione-depleting agents, increases the sensitivity of cells to arsenic toxicity. Formation of ROS/RNS, including peroxyl radicals (ROO•), the superoxide radical, singlet oxygen, hydroxyl radical (OH•) via the Fenton reaction, hydrogen peroxide, the dimethylarsenic radical, the dimethylarsenic peroxyl radical and/or oxidant-induced DNA damage, when both humans and animals are exposed to arsenic. In addition, arsenic induces the formation of oxidized lipids which in turn generate several bioactive molecules (ROS, peroxides and isoprostanes), of which aldehydes [malondialdehyde (MDA) and 4-hydroxy-nonenal (HNE)] are the major end products. Various traditional antidotes are recommended for the present study such as DMSA (meso-2,3-dimercaptosuccinic acid), DMPS(2,3-dimercapto-1-propanesulfonic acid) DMPA (N-(2,3-dimercaptopropyl)-phthalamidic acid) BAL (2,3-dimercapto-1-propanol), Taurine (2-aminoethaesulfonic acid) against arsenic-induced toxicity. Recently, such phyto-antidotes like silibinin, arjunolic acid, vitamin C (ascorbic acid), vitamin E (α-tocopherol) and curcumin have played a major role in arsenic toxicity. Glutathione and antioxidant enzymes such as superoxide dismutase, catalase and glutathione peroxidase showed the protective role against arsenic-induced oxidative stress
Abstract Fluoride intoxication generates free radicals, causing oxidative stress that plays a cri... more Abstract Fluoride intoxication generates free radicals, causing oxidative stress that plays a critical role in the progression of nephropathy. In the present study, we hypothesized that epigallocatechin gallate (EGCG), found in green tea, protects the kidneys of rats treated with fluoride by preventing oxidative stress, inflammation, and apoptosis. Pretreatment of fluoride-treated rats with EGCG resulted in a significant normalization of creatinine clearance and levels of urea, uric acid, and creatinine. Fluoride intoxication significantly increased renal oxidative stress markers and decreased the levels of renal enzymatic and non-enzymatic antioxidants. In addition, renal NO, TNF-α, IL-6 and NF-κB were also increased in the renal tissue of fluoride-treated rats. Further, EGCG pretreatment produced a significant improvement in renal antioxidant status and reduced lipid peroxidation, protein carbonylation and the levels of inflammatory markers in fluoride-treated kidney. Similarly, m...
ABSTRACT Abstract The efficacy of diallyl trisulfide (DATS) against arsenic (As) induced dyslipid... more ABSTRACT Abstract The efficacy of diallyl trisulfide (DATS) against arsenic (As) induced dyslipidemia in the plasma and livers of rats was studied. Oral administration of As [5 mg/kg of body weight (BW)/d] for 4 weeks showed significant (p&lt;0.05) increases in TC, LDL-C, VLDL-C, FFA, PL, and TGs, levels and the activity of HMG-CoA reductase in the plasma and liver with significant (p&lt;0.05) reductions in levels of HDL-C hepatic ubiquinones and activities of LCAT and LPL in the plasma and liver. Oral administration of DATS (80 mg/kg of BW) for 4 weeks in As intoxicated rats significantly (p&lt;0.05) reduced plasma and liver TC, FFA, TGs, VLDL-C, and LDL-C levels, and the activity of HMG-CoA reductase, and significantly (p&lt;0.05) increased the activities of LCAT and LPL and the levels of HDL-C and ubiquinone in the livers of rats. DATS protects against As-induced dyslipidemia in rats.
Abstract Fluorine (Fl) a member of the halogen family is the most electronegative and reactive of... more Abstract Fluorine (Fl) a member of the halogen family is the most electronegative and reactive of all the elements of Periodic table. Chronic and acute exposures of fluoride leads to cardiovascular disease (hypertension and atherosclerosis), neurological disorders, gastrointestinal disturbances, liver disease, renal disease, reproductive effects, other health disorders and also affects the antioxidant system in the body. Furthermore, reactive oxygen species (ROS)-mediated oxidative damage is a common malady in fluoride pathogenesis. Formation of free radical due to cascade mechanism combined with glutathione-depleting agents increases the oxidation process in the cells and cause damage. Formation of ROS/RNS including peroxyl radicals (ROO•) the superoxide radical, singlet oxygen and hydroxyl radical (OH•) via the Fenton reaction direct DNA damages when both humans and animals are exposed to fluoride. In addition, fluoride induces the formation of oxidized lipids which in turn genera...
The present work was carried out to evaluate the hepatoprotective effect of A. paniculata, a popu... more The present work was carried out to evaluate the hepatoprotective effect of A. paniculata, a popular Indian ethnomedicine in the liver of cadmium chloride intoxicated rats. Oral administration of cadmium (5mg/kg body wt.) for 30 days resulted in a significant (p<0.01) elevation of serum aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and bilirubin and the levels of lipid peroxidation marker, malondialdehyde (MDA) in liver. Cadmium also caused a significant reduction in the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and reduced the glutathione level in liver. Prior oral administration of A. paniculata extract (100 mg/kg body wt.) with cadmium chloride significantly decreased the serum hepatic marker enzymes viz., AST, ALT, ALP, LDH and the level of bilirubin along with the significant decrease in the levels of lipid peroxidation in the liver. In addition the A.pa...
Arsenic is a well known toxic metalloid which induces a broad spectrum of toxicological effects, ... more Arsenic is a well known toxic metalloid which induces a broad spectrum of toxicological effects, biochemical dysfunctions and dyslipidemia, constituting serious hazard to health. DiMC is sound recognized for its antioxidant, anti-cancer, anti-inflammatory and anti-apoptotic actions. Hence the present study was designed to examine the antihyperlipidemic effect of Dimethoxycurcumin (DiMC) against arsenic induced dyslipidemia in rats. Oral administration of As (5 mg/kg of body weight (BW)/d) for 4 weeks showed significant (p<0.05) elevated levels of TC, LDL-C, VLDL-C, FFA, PL, and TGs, and the activity of HMG-CoA reductase in the plasma and liver with significant (p<0.05) reductions in levels of HDL-C hepatic ubiquinones and activities of LCAT and LPL in the plasma and liver. Pre-administration of DiMC (80 mg/kg of BW) for 4 weeks in As intoxicated rats significantly (p<0.05) reduced plasma and liver TC, FFA, TGs, VLDL-C, and LDL-C levels, and the activity of HMG-CoA reductase...
European review for medical and pharmacological sciences, 2011
BACKGROUND Cadmium is a potent neurotoxic heavy metal, which induces oxidative stress and membran... more BACKGROUND Cadmium is a potent neurotoxic heavy metal, which induces oxidative stress and membrane disturbances in brain. Melatonin is an effective antioxidant and free radical scavenger against oxidative stress. The present study was designed to investigate the neuroprotective efficacy of melatonin in protecting the Cd induced changes in the activity of acetylcholinesterase (AChE), levels of lipid peroxidation, protein carbonyls, non-enzymatic antioxidant, enzymatic antioxidant status, membrane bound ATPases and histopathology in the brain of rats. MATERIALS AND METHODS Twenty four male albino rats were used. Cadmium induced oxidative neurotoxicity was induced by oral administration of Cd for four weeks. Melatonin was pretreated along with Cd for four weeks to assess its neuroprotective activity against Cd intoxication. Rats treated with vehicles alone were used as controls. RESULTS Rats intoxicated with cadmium (5 mg/kg/day) for 4 weeks significantly (p < 0.05) reduced the AChE...
Abstract Curcumin, a major constituent of turmeric (Curcuma longa) which has been reported to hav... more Abstract Curcumin, a major constituent of turmeric (Curcuma longa) which has been reported to have a wide spectrum of pharmacological activities. The present work was carried out to evaluate the effect of curcumin on serum hepatic marker enzymes, ...
This study was carried out to evaluate the effect of dietary vitamins C (ascorbic acid) and E (α-... more This study was carried out to evaluate the effect of dietary vitamins C (ascorbic acid) and E (α-tocopherol) on serum hepatic marker enzymes, antioxidant and lipid peroxidation status in liver of cadmium intoxicated rats. Administration of cadmium chloride (5 mg/kg body wt/day) for ...
Research & Reviews: A Journal of Toxicology, Sep 1, 2014
The aim of the study was to investigate the in vivo circulating antioxidants level such as vitami... more The aim of the study was to investigate the in vivo circulating antioxidants level such as vitamin C, vitamin E and GSH in Cadmium (Cd) induced toxic rats and the protective efficacy of naringenin via in vitro free radical scavenging assays. In this investigation cadmium chloride (5 mg/kg body weight (b.w) was administered orally (p.o) for 28 days to induce toxicity. Naringenin was pre-administered orally (50 mg/kg body weight) for 28 days with cadmium chloride. The toxic effect of cadmium was indicated by significantly decreased activities of non-enzymatic antioxidants like reduced glutathione, vitamin C and vitamin E. Treatment with naringenin exhibited a significant (P < 0.05) increase in Cd-induced rats. The free radical scavenging properties of naringenin were investigated with different in vitro methods such as 2, 2 ¢ -diphenyl-1-picrylhydrazyl radical (DPPH•), 2,2’-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) radical (ABTS•+), hydroxyl radical, superoxide anion scavenging activity and reducing power. In addition to that ascorbic acid, butylated hydroxyl toluene was used as the reference antioxidant radical scavenger compounds. Among the different concentration, 500 μM of naringenin had significantly effective compared to other concentration in all in vitro assay. Based on these findings naringenin possess potent in vivo and in vitro antioxidant efficacy and also effective free radical scavenger, augmenting its therapeutic value.
Fluoride (Fl) exposure engenders neurodegeneration in the brain. The Neuroprotective role of EGCG... more Fluoride (Fl) exposure engenders neurodegeneration in the brain. The Neuroprotective role of EGCG against Fl induced neurotoxicity in rat hippocampus has not yet been explored so far. In this present exploration we focused to witness whether EGCG (40mg/kg) prevents the Fl induced oxidative stress in the brain of rats with special emphasis on hippocampus. Fl (25mg/kg) intoxication for 4 weeks shows decreased neurotransmitters (AChE, NP, DA and 5-HT) in the brain. The oxidative stress markers (ROS, TBARS, NO and PC) were significantly increased with decreased enzymatic (SOD, CAT, GPx, GR, GST, and G6PD) and non-enzymatic antioxidants (GSH, TSH and Vit.C) in Fl intoxicated rat hippocampus. Moreover, Fl intoxicated rats showed an intrinsic and extrinsic pathway mediated apoptosis in the hippocampus of rats. Fl significantly increased the DNA damage as evidenced by increased DNA fragmentation. Furthermore, the toxic impact of Fl on hippocampus was also proved by the immunohistochemical, histological and ultra-structural studies. Pre-administration of EGCG significantly protected the rat brain and hippocampus against Fl ROS by its strong antioxidant and free radical scavenging ability.
Abstract Heavy metal pollutants are generally discharged in the aquatic environment as a result o... more Abstract Heavy metal pollutants are generally discharged in the aquatic environment as a result of industrial processes and are causing major problems in the food chain. Pollution due to heavy metals is of serious concern and among them cadmium deserves special ...
Endosulfan is an important hepatotoxic agent that generates free oxygen radicals in liver and the... more Endosulfan is an important hepatotoxic agent that generates free oxygen radicals in liver and the incidence of toxic injury to the liver tissue in relation to its widespread has been reported. Bamboo is rich in phenolic components which possess various bioactivities and bamboo seed extract was found to have antioxidative properties. Hence, the present study has been designed to assess the protective role of bamboo seed extract against endosulfan induced hepatotoxicity in rat as the endosulfan can persistent to environment where its attributes lead to bioconcentration and biomagnification in certain food chains. For experiments male albino rats weighing 170–190 g were randomly selected and divided into four groups consisting of six rats in each group. The hepatotoxic effects of oral administration of endosulfan (15 mg/kg B.W) and hepato-protective effect of co-administration of bamboo seed extract (90 mg/kg B.W) with endosulfan daily for 10 days, were investigated in rats using serum...
ABSTRACT Arsenic (As) is a metalloid listed in group Va of the periodic chart. It exists in natur... more ABSTRACT Arsenic (As) is a metalloid listed in group Va of the periodic chart. It exists in nature in the oxidation states +V (arsenate), +III (arsenite), 0 (arsenic) and −III (arsine). In the aqueous environment inorganic arsenic appears commonly in the oxidation states +V and +III as arsenous acid (As (III)), arsenic acid (As (V)), and their salts. Chronic and acute exposures of arsenic leads to cancer, cardiovascular disease (hypertension and atherosclerosis), neurological disorders, gastrointestinal disturbances, liver disease and renal disease, reproductive health effects, dermal changes and other health disorders and also affects the antioxidant system in the body. Furthermore, reactive oxygen species (ROS)-mediated oxidative damage is a common denominator in arsenic pathogenesis. Formation of free radical such as superoxide radical due to cascade mechanism, combined with glutathione-depleting agents, increases the sensitivity of cells to arsenic toxicity. Formation of ROS/RNS, including peroxyl radicals (ROO•), the superoxide radical, singlet oxygen, hydroxyl radical (OH•) via the Fenton reaction, hydrogen peroxide, the dimethylarsenic radical, the dimethylarsenic peroxyl radical and/or oxidant-induced DNA damage, when both humans and animals are exposed to arsenic. In addition, arsenic induces the formation of oxidized lipids which in turn generate several bioactive molecules (ROS, peroxides and isoprostanes), of which aldehydes [malondialdehyde (MDA) and 4-hydroxy-nonenal (HNE)] are the major end products. Various traditional antidotes are recommended for the present study such as DMSA (meso-2,3-dimercaptosuccinic acid), DMPS(2,3-dimercapto-1-propanesulfonic acid) DMPA (N-(2,3-dimercaptopropyl)-phthalamidic acid) BAL (2,3-dimercapto-1-propanol), Taurine (2-aminoethaesulfonic acid) against arsenic-induced toxicity. Recently, such phyto-antidotes like silibinin, arjunolic acid, vitamin C (ascorbic acid), vitamin E (α-tocopherol) and curcumin have played a major role in arsenic toxicity. Glutathione and antioxidant enzymes such as superoxide dismutase, catalase and glutathione peroxidase showed the protective role against arsenic-induced oxidative stress
Abstract Fluoride intoxication generates free radicals, causing oxidative stress that plays a cri... more Abstract Fluoride intoxication generates free radicals, causing oxidative stress that plays a critical role in the progression of nephropathy. In the present study, we hypothesized that epigallocatechin gallate (EGCG), found in green tea, protects the kidneys of rats treated with fluoride by preventing oxidative stress, inflammation, and apoptosis. Pretreatment of fluoride-treated rats with EGCG resulted in a significant normalization of creatinine clearance and levels of urea, uric acid, and creatinine. Fluoride intoxication significantly increased renal oxidative stress markers and decreased the levels of renal enzymatic and non-enzymatic antioxidants. In addition, renal NO, TNF-α, IL-6 and NF-κB were also increased in the renal tissue of fluoride-treated rats. Further, EGCG pretreatment produced a significant improvement in renal antioxidant status and reduced lipid peroxidation, protein carbonylation and the levels of inflammatory markers in fluoride-treated kidney. Similarly, m...
ABSTRACT Abstract The efficacy of diallyl trisulfide (DATS) against arsenic (As) induced dyslipid... more ABSTRACT Abstract The efficacy of diallyl trisulfide (DATS) against arsenic (As) induced dyslipidemia in the plasma and livers of rats was studied. Oral administration of As [5 mg/kg of body weight (BW)/d] for 4 weeks showed significant (p&lt;0.05) increases in TC, LDL-C, VLDL-C, FFA, PL, and TGs, levels and the activity of HMG-CoA reductase in the plasma and liver with significant (p&lt;0.05) reductions in levels of HDL-C hepatic ubiquinones and activities of LCAT and LPL in the plasma and liver. Oral administration of DATS (80 mg/kg of BW) for 4 weeks in As intoxicated rats significantly (p&lt;0.05) reduced plasma and liver TC, FFA, TGs, VLDL-C, and LDL-C levels, and the activity of HMG-CoA reductase, and significantly (p&lt;0.05) increased the activities of LCAT and LPL and the levels of HDL-C and ubiquinone in the livers of rats. DATS protects against As-induced dyslipidemia in rats.
Abstract Fluorine (Fl) a member of the halogen family is the most electronegative and reactive of... more Abstract Fluorine (Fl) a member of the halogen family is the most electronegative and reactive of all the elements of Periodic table. Chronic and acute exposures of fluoride leads to cardiovascular disease (hypertension and atherosclerosis), neurological disorders, gastrointestinal disturbances, liver disease, renal disease, reproductive effects, other health disorders and also affects the antioxidant system in the body. Furthermore, reactive oxygen species (ROS)-mediated oxidative damage is a common malady in fluoride pathogenesis. Formation of free radical due to cascade mechanism combined with glutathione-depleting agents increases the oxidation process in the cells and cause damage. Formation of ROS/RNS including peroxyl radicals (ROO•) the superoxide radical, singlet oxygen and hydroxyl radical (OH•) via the Fenton reaction direct DNA damages when both humans and animals are exposed to fluoride. In addition, fluoride induces the formation of oxidized lipids which in turn genera...
The present work was carried out to evaluate the hepatoprotective effect of A. paniculata, a popu... more The present work was carried out to evaluate the hepatoprotective effect of A. paniculata, a popular Indian ethnomedicine in the liver of cadmium chloride intoxicated rats. Oral administration of cadmium (5mg/kg body wt.) for 30 days resulted in a significant (p<0.01) elevation of serum aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and bilirubin and the levels of lipid peroxidation marker, malondialdehyde (MDA) in liver. Cadmium also caused a significant reduction in the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and reduced the glutathione level in liver. Prior oral administration of A. paniculata extract (100 mg/kg body wt.) with cadmium chloride significantly decreased the serum hepatic marker enzymes viz., AST, ALT, ALP, LDH and the level of bilirubin along with the significant decrease in the levels of lipid peroxidation in the liver. In addition the A.pa...
Arsenic is a well known toxic metalloid which induces a broad spectrum of toxicological effects, ... more Arsenic is a well known toxic metalloid which induces a broad spectrum of toxicological effects, biochemical dysfunctions and dyslipidemia, constituting serious hazard to health. DiMC is sound recognized for its antioxidant, anti-cancer, anti-inflammatory and anti-apoptotic actions. Hence the present study was designed to examine the antihyperlipidemic effect of Dimethoxycurcumin (DiMC) against arsenic induced dyslipidemia in rats. Oral administration of As (5 mg/kg of body weight (BW)/d) for 4 weeks showed significant (p<0.05) elevated levels of TC, LDL-C, VLDL-C, FFA, PL, and TGs, and the activity of HMG-CoA reductase in the plasma and liver with significant (p<0.05) reductions in levels of HDL-C hepatic ubiquinones and activities of LCAT and LPL in the plasma and liver. Pre-administration of DiMC (80 mg/kg of BW) for 4 weeks in As intoxicated rats significantly (p<0.05) reduced plasma and liver TC, FFA, TGs, VLDL-C, and LDL-C levels, and the activity of HMG-CoA reductase...
European review for medical and pharmacological sciences, 2011
BACKGROUND Cadmium is a potent neurotoxic heavy metal, which induces oxidative stress and membran... more BACKGROUND Cadmium is a potent neurotoxic heavy metal, which induces oxidative stress and membrane disturbances in brain. Melatonin is an effective antioxidant and free radical scavenger against oxidative stress. The present study was designed to investigate the neuroprotective efficacy of melatonin in protecting the Cd induced changes in the activity of acetylcholinesterase (AChE), levels of lipid peroxidation, protein carbonyls, non-enzymatic antioxidant, enzymatic antioxidant status, membrane bound ATPases and histopathology in the brain of rats. MATERIALS AND METHODS Twenty four male albino rats were used. Cadmium induced oxidative neurotoxicity was induced by oral administration of Cd for four weeks. Melatonin was pretreated along with Cd for four weeks to assess its neuroprotective activity against Cd intoxication. Rats treated with vehicles alone were used as controls. RESULTS Rats intoxicated with cadmium (5 mg/kg/day) for 4 weeks significantly (p < 0.05) reduced the AChE...
Uploads
Papers by Milton Prabu