The unique contribution of the serotonin transporter-linked polymorphic region (5-HTTLPR), intron... more The unique contribution of the serotonin transporter-linked polymorphic region (5-HTTLPR), intronic region 2 (STin2), and monoamine oxidase A (MAO-A) genes to individual differences in personality traits has been widely explored, and research has shown that certain forms of these polymorphisms relate to impulsivity and impulsivity-related disorders. Humans showing these traits are also described as having an asymmetrical prefrontal cortical activity when compared to others. In this explorative study, we examine the relationship between serotonergic neurotransmission polymorphisms, cortical activity features (prefrontal alpha asymmetry, individual alpha peak frequency [iAPF]), emotion-related and non-emotion-related impulsivity in humans. 5-HTTLPR, MAO-A, and STin2 polymorphisms were assessed in blood taken from 91 participants with high emotion-related impulsivity levels. Sixty-seven participants completed resting electroencephalography and a more comprehensive impulsivity index. In...
BackgroundThe dominance behavioral system (DBS) is a biologically based system that underpins ind... more BackgroundThe dominance behavioral system (DBS) is a biologically based system that underpins individual differences in motivation for dominance and power. However, little is known about the DBS in childhood. In order to make strong claims about the DBS’s trait-like properties and predictive validity, a clearer understanding of its early development is required.Participants and procedureIn a pilot study aimed at developing a behavioral coding system for dominance, a key facet of the DBS, we collected and coded observational data from 58 children, assessed at ages 3 and 5-6. These data were examined in conjunction with measures of child temperament via observational measures, and symptoms of psychopathology.ResultsDominance was moderately stable in early childhood to a degree comparable to other early child temperament traits. Con-sistent with the study hypotheses, boys were more dominant than girls, and dominance was negatively associated with children’s behavioral inhibition, effor...
Journal of racial and ethnic health disparities, Jan 29, 2016
Due to the serious and recurrent nature of bipolar disorder, continuous long-term medication trea... more Due to the serious and recurrent nature of bipolar disorder, continuous long-term medication treatment is typically recommended. Little is known about whether these treatment recommendations are effectively implemented for Hispanics. This study examined differences in mood stabilizer use and mental health service utilization between adult English-speaking Hispanic and non-Hispanic white respondents with bipolar disorder. The sample included 163 participants with lifetime bipolar I and II disorders in the National Comorbidity Survey Replication. Demographics, symptom presentation, and acculturation were examined as covariates. None of the 26 Hispanic respondents were taking mood-stabilizing medication, compared to 21 % of non-Hispanic whites, and Hispanics were less likely to receive medications for emotional problems, see a professional for manic episodes, or attend psychotherapy. Even after accounting for differences in symptom profiles and sociodemographics, ethnicity continued to...
Background Despite increasing evidence for the effectiveness of individual psychological interven... more Background Despite increasing evidence for the effectiveness of individual psychological interventions for bipolar disorder, research on older adults is lacking. We report the first randomised controlled trial of psychological therapy designed specifically for older adults with bipolar disorder. Aims To evaluate the feasibility and acceptability of recovery-focused therapy, designed in collaboration with older people living with bipolar disorder. Method A parallel, two-armed, randomised controlled trial comparing treatment as usual with up to 14 sessions of recovery-focused therapy plus treatment as usual, for older adults with bipolar disorder. Results Thirty-nine participants (67% female, mean age 67 years) were recruited over a 17-month period. Feasibility and acceptability of recruitment, retention (>80% observer-rated outcomes at both 24 and 48 weeks) and intervention processes were demonstrated. The majority of participants started therapy when offered, adhered to the inter...
BACKGROUND US suicide rates have risen steadily in the past decade, and suicide risk is especiall... more BACKGROUND US suicide rates have risen steadily in the past decade, and suicide risk is especially high in the months after discharge from inpatient psychiatric treatment. However, suicide research has lagged in examining dynamic within-person processes that contribute to risk over time among individuals known to be at high risk of suicide. Almost no research has examined how affective, cognitive, and physiological processes change over minutes, hours, or days to confer risk of suicidal behavior in daily life. OBJECTIVE This protocol describes a longitudinal study designed to examine real-world changes in risk of suicide across multiple assessment domains. Specifically, the study involves following adults known to be at high risk of suicide after discharge from inpatient psychiatric care using self-report, interview, actigraphy, and behavioral methods to identify proximal contributors to suicidal thoughts and behaviors. First, we hypothesize that negative affective experiences, whic...
Recent research has highlighted that emotion regulation strategy use varies both between and with... more Recent research has highlighted that emotion regulation strategy use varies both between and within people, and specific individual and contextual differences shape strategy use. Further, use of specific emotion regulation strategies relates to a wide array of differential outcomes, including mental health and behavior. Emotion goals (desire for a given emotion state) are thought to play a particularly important role in shaping people’s use of emotion regulation strategies; yet, surprisingly little is known about whether and how momentary emotion goals predict spontaneous strategy use in daily life. In the present investigation, we examined whether ideal desire for high versus low arousal positive affect was associated with subsequent use of specific emotion regulation strategies. Undergraduate participants (final N = 101) completed ecological momentary assessments (final ks = 1,932 for contemporaneous analyses, 1,386 for time-lagged analyses) of their momentary experienced affect, ...
Impulsivity is defined as a trait-like tendency to engage in rash actions that are poorly thought... more Impulsivity is defined as a trait-like tendency to engage in rash actions that are poorly thought out or expressed in an untimely manner. Previous research has found that impulsivity relates to deficits in decision making, in particular when it necessitates executive control or reward outcomes. Reinforcement learning (RL) relies on the ability to integrate valenced outcomes to make good decisions, and has recently be shown to often recruit executive function; as such, it is unsurprising that impulsivity has been studied in the context of RL. However, how impulsivity relates to the mechanisms of RL remains unclear. We aimed to investigate the relationship between impulsivity and learning in a reward-driven learning task with probabilistic feedback and reversal known to recruit executive function. Based on prior literature in clinical populations, we predicted that higher impulsivity would be associated with poorer performance on the task, driven by more frequent switching following u...
There has been extensive discussion about gender gaps in representation and career advancement in... more There has been extensive discussion about gender gaps in representation and career advancement in the sciences. However, psychological science itself has yet to be the focus of discussion or systematic review, despite our field’s investment in questions of equity, status, well-being, gender bias, and gender disparities. In the present article, we consider 10 topics relevant for women’s career advancement in psychological science. We focus on issues that have been the subject of empirical study, discuss relevant evidence within and outside of psychological science, and draw on established psychological theory and social-science research to begin to chart a path forward. We hope that better understanding of these issues within the field will shed light on areas of existing gender gaps in the discipline and areas where positive change has happened, and spark conversation within our field about how to create lasting change to mitigate remaining gender differences in psychological science.
Because of its prevalence, depression has been described as the common cold of mental illness. To... more Because of its prevalence, depression has been described as the common cold of mental illness. To receive a diagnosis of major depression, an individual must experience the following symptoms for a period of 2 weeks or more: sad mood or loss of pleasure, with at least four ...
Drawing on literature linking bipolar disorder to both creativity and heightened motivation, our ... more Drawing on literature linking bipolar disorder to both creativity and heightened motivation, our aim was to examine whether heightened motivation might contribute to creativity in those with and without bipolar disorder. To examine this, we recruited persons diagnosed with bipolar disorder (n = 49), and persons with no diagnosis of bipolar disorder (n = 37), with over-sampling of those from creative occupations. We gathered measures of lifetime creative accomplishment (Creative Accomplishment Questionnaire), willingness to persist as a creativity task became increasingly difficult (the Compound Remote Associates task) divergent thinking (Unusual Uses Test), self-rated high ambitions (The Willingly Approached Set of Statistically Unlikely Pursuits scale)) and a behavioral measure of willingness to exert physical effort for reward (the Effort Discounting Task). In multiple linear regression models controlling for age and examining the unique effects of the motivation variables, two be...
Prominent cognitive deficits have been documented in bipolar disorder, and multiple studies sugge... more Prominent cognitive deficits have been documented in bipolar disorder, and multiple studies suggest that these deficits can be observed among non-affected first-degree relatives of those with bipolar disorder. Although there is variability in the degree of cognitive deficits, these deficits are robustly relevant for functional outcomes. A separate literature documents clear difficulties in emotionality, emotion regulation, and emotion-relevant impulsivity within bipolar disorder, and demonstrates that these emotion-relevant variables are also central to outcome. Although cognitive and emotion domains are typically studied independently, basic research and emergent findings in bipolar disorder suggest that there are important ties between cognitive deficits and the emotion disturbances observed in bipolar disorder. Understanding these relationships has relevance for fostering more integrative research, for clarifying relevant aspects related to functionality and vulnerability within ...
Journal of behavior therapy and experimental psychiatry, Jan 23, 2015
People prone to mania use emotion regulation (ER) strategies well when explicitly coached to do s... more People prone to mania use emotion regulation (ER) strategies well when explicitly coached to do so in laboratory settings, but they find these strategies ineffective in daily life. We hypothesized that, compared with control participants, mania-prone people would show ER deficits when they received implicit, but not explicit, cues to use ER. Undergraduates (N = 66) completed the Hypomanic Personality Scale (HPS) and were randomly assigned to one of three experimental conditions: automatic ER (scrambled sentence primes), deliberate ER (verbal instructions), or control (no priming or instructions to use ER). Then, participants played a videogame designed to evoke anger. Emotion responses were measured with a multi-modal assessment of self-reported affect, psychophysiology, and facial expressions. Respiratory sinus arrhythmia (RSA) was used to index ER. The videogame effectively elicited subjective anger, angry facial expressions, and heart rate increases when keys malfunctioned. As hy...
Prior research suggests that a traitlike tendency to experience impulsivity during states of high... more Prior research suggests that a traitlike tendency to experience impulsivity during states of high emotion is robustly associated with many forms of psychopathology. Several studies tie emotion‐related impulsivity to response inhibition deficits, but these studies have not focused on the role of emotion or arousal within subjects. The present study tested whether arousal, measured by pupil dilation, amplifies deficits in response inhibition for those high in emotion‐related impulsivity. Participants (N = 85) completed a measure of emotion‐related impulsivity, underwent a positive mood induction procedure that reduced heterogeneity in mood states, and completed a response inhibition task. Pupil dilation was used to index arousal during the response inhibition task. Generalized linear mixed effect modeling yielded the hypothesized interaction between arousal (pupil dilation) and emotion‐related impulsivity in predicting response inhibition performance at the trial level. Emotion‐relate...
The unique contribution of the serotonin transporter-linked polymorphic region (5-HTTLPR), intron... more The unique contribution of the serotonin transporter-linked polymorphic region (5-HTTLPR), intronic region 2 (STin2), and monoamine oxidase A (MAO-A) genes to individual differences in personality traits has been widely explored, and research has shown that certain forms of these polymorphisms relate to impulsivity and impulsivity-related disorders. Humans showing these traits are also described as having an asymmetrical prefrontal cortical activity when compared to others. In this explorative study, we examine the relationship between serotonergic neurotransmission polymorphisms, cortical activity features (prefrontal alpha asymmetry, individual alpha peak frequency [iAPF]), emotion-related and non-emotion-related impulsivity in humans. 5-HTTLPR, MAO-A, and STin2 polymorphisms were assessed in blood taken from 91 participants with high emotion-related impulsivity levels. Sixty-seven participants completed resting electroencephalography and a more comprehensive impulsivity index. In...
BackgroundThe dominance behavioral system (DBS) is a biologically based system that underpins ind... more BackgroundThe dominance behavioral system (DBS) is a biologically based system that underpins individual differences in motivation for dominance and power. However, little is known about the DBS in childhood. In order to make strong claims about the DBS’s trait-like properties and predictive validity, a clearer understanding of its early development is required.Participants and procedureIn a pilot study aimed at developing a behavioral coding system for dominance, a key facet of the DBS, we collected and coded observational data from 58 children, assessed at ages 3 and 5-6. These data were examined in conjunction with measures of child temperament via observational measures, and symptoms of psychopathology.ResultsDominance was moderately stable in early childhood to a degree comparable to other early child temperament traits. Con-sistent with the study hypotheses, boys were more dominant than girls, and dominance was negatively associated with children’s behavioral inhibition, effor...
Journal of racial and ethnic health disparities, Jan 29, 2016
Due to the serious and recurrent nature of bipolar disorder, continuous long-term medication trea... more Due to the serious and recurrent nature of bipolar disorder, continuous long-term medication treatment is typically recommended. Little is known about whether these treatment recommendations are effectively implemented for Hispanics. This study examined differences in mood stabilizer use and mental health service utilization between adult English-speaking Hispanic and non-Hispanic white respondents with bipolar disorder. The sample included 163 participants with lifetime bipolar I and II disorders in the National Comorbidity Survey Replication. Demographics, symptom presentation, and acculturation were examined as covariates. None of the 26 Hispanic respondents were taking mood-stabilizing medication, compared to 21 % of non-Hispanic whites, and Hispanics were less likely to receive medications for emotional problems, see a professional for manic episodes, or attend psychotherapy. Even after accounting for differences in symptom profiles and sociodemographics, ethnicity continued to...
Background Despite increasing evidence for the effectiveness of individual psychological interven... more Background Despite increasing evidence for the effectiveness of individual psychological interventions for bipolar disorder, research on older adults is lacking. We report the first randomised controlled trial of psychological therapy designed specifically for older adults with bipolar disorder. Aims To evaluate the feasibility and acceptability of recovery-focused therapy, designed in collaboration with older people living with bipolar disorder. Method A parallel, two-armed, randomised controlled trial comparing treatment as usual with up to 14 sessions of recovery-focused therapy plus treatment as usual, for older adults with bipolar disorder. Results Thirty-nine participants (67% female, mean age 67 years) were recruited over a 17-month period. Feasibility and acceptability of recruitment, retention (>80% observer-rated outcomes at both 24 and 48 weeks) and intervention processes were demonstrated. The majority of participants started therapy when offered, adhered to the inter...
BACKGROUND US suicide rates have risen steadily in the past decade, and suicide risk is especiall... more BACKGROUND US suicide rates have risen steadily in the past decade, and suicide risk is especially high in the months after discharge from inpatient psychiatric treatment. However, suicide research has lagged in examining dynamic within-person processes that contribute to risk over time among individuals known to be at high risk of suicide. Almost no research has examined how affective, cognitive, and physiological processes change over minutes, hours, or days to confer risk of suicidal behavior in daily life. OBJECTIVE This protocol describes a longitudinal study designed to examine real-world changes in risk of suicide across multiple assessment domains. Specifically, the study involves following adults known to be at high risk of suicide after discharge from inpatient psychiatric care using self-report, interview, actigraphy, and behavioral methods to identify proximal contributors to suicidal thoughts and behaviors. First, we hypothesize that negative affective experiences, whic...
Recent research has highlighted that emotion regulation strategy use varies both between and with... more Recent research has highlighted that emotion regulation strategy use varies both between and within people, and specific individual and contextual differences shape strategy use. Further, use of specific emotion regulation strategies relates to a wide array of differential outcomes, including mental health and behavior. Emotion goals (desire for a given emotion state) are thought to play a particularly important role in shaping people’s use of emotion regulation strategies; yet, surprisingly little is known about whether and how momentary emotion goals predict spontaneous strategy use in daily life. In the present investigation, we examined whether ideal desire for high versus low arousal positive affect was associated with subsequent use of specific emotion regulation strategies. Undergraduate participants (final N = 101) completed ecological momentary assessments (final ks = 1,932 for contemporaneous analyses, 1,386 for time-lagged analyses) of their momentary experienced affect, ...
Impulsivity is defined as a trait-like tendency to engage in rash actions that are poorly thought... more Impulsivity is defined as a trait-like tendency to engage in rash actions that are poorly thought out or expressed in an untimely manner. Previous research has found that impulsivity relates to deficits in decision making, in particular when it necessitates executive control or reward outcomes. Reinforcement learning (RL) relies on the ability to integrate valenced outcomes to make good decisions, and has recently be shown to often recruit executive function; as such, it is unsurprising that impulsivity has been studied in the context of RL. However, how impulsivity relates to the mechanisms of RL remains unclear. We aimed to investigate the relationship between impulsivity and learning in a reward-driven learning task with probabilistic feedback and reversal known to recruit executive function. Based on prior literature in clinical populations, we predicted that higher impulsivity would be associated with poorer performance on the task, driven by more frequent switching following u...
There has been extensive discussion about gender gaps in representation and career advancement in... more There has been extensive discussion about gender gaps in representation and career advancement in the sciences. However, psychological science itself has yet to be the focus of discussion or systematic review, despite our field’s investment in questions of equity, status, well-being, gender bias, and gender disparities. In the present article, we consider 10 topics relevant for women’s career advancement in psychological science. We focus on issues that have been the subject of empirical study, discuss relevant evidence within and outside of psychological science, and draw on established psychological theory and social-science research to begin to chart a path forward. We hope that better understanding of these issues within the field will shed light on areas of existing gender gaps in the discipline and areas where positive change has happened, and spark conversation within our field about how to create lasting change to mitigate remaining gender differences in psychological science.
Because of its prevalence, depression has been described as the common cold of mental illness. To... more Because of its prevalence, depression has been described as the common cold of mental illness. To receive a diagnosis of major depression, an individual must experience the following symptoms for a period of 2 weeks or more: sad mood or loss of pleasure, with at least four ...
Drawing on literature linking bipolar disorder to both creativity and heightened motivation, our ... more Drawing on literature linking bipolar disorder to both creativity and heightened motivation, our aim was to examine whether heightened motivation might contribute to creativity in those with and without bipolar disorder. To examine this, we recruited persons diagnosed with bipolar disorder (n = 49), and persons with no diagnosis of bipolar disorder (n = 37), with over-sampling of those from creative occupations. We gathered measures of lifetime creative accomplishment (Creative Accomplishment Questionnaire), willingness to persist as a creativity task became increasingly difficult (the Compound Remote Associates task) divergent thinking (Unusual Uses Test), self-rated high ambitions (The Willingly Approached Set of Statistically Unlikely Pursuits scale)) and a behavioral measure of willingness to exert physical effort for reward (the Effort Discounting Task). In multiple linear regression models controlling for age and examining the unique effects of the motivation variables, two be...
Prominent cognitive deficits have been documented in bipolar disorder, and multiple studies sugge... more Prominent cognitive deficits have been documented in bipolar disorder, and multiple studies suggest that these deficits can be observed among non-affected first-degree relatives of those with bipolar disorder. Although there is variability in the degree of cognitive deficits, these deficits are robustly relevant for functional outcomes. A separate literature documents clear difficulties in emotionality, emotion regulation, and emotion-relevant impulsivity within bipolar disorder, and demonstrates that these emotion-relevant variables are also central to outcome. Although cognitive and emotion domains are typically studied independently, basic research and emergent findings in bipolar disorder suggest that there are important ties between cognitive deficits and the emotion disturbances observed in bipolar disorder. Understanding these relationships has relevance for fostering more integrative research, for clarifying relevant aspects related to functionality and vulnerability within ...
Journal of behavior therapy and experimental psychiatry, Jan 23, 2015
People prone to mania use emotion regulation (ER) strategies well when explicitly coached to do s... more People prone to mania use emotion regulation (ER) strategies well when explicitly coached to do so in laboratory settings, but they find these strategies ineffective in daily life. We hypothesized that, compared with control participants, mania-prone people would show ER deficits when they received implicit, but not explicit, cues to use ER. Undergraduates (N = 66) completed the Hypomanic Personality Scale (HPS) and were randomly assigned to one of three experimental conditions: automatic ER (scrambled sentence primes), deliberate ER (verbal instructions), or control (no priming or instructions to use ER). Then, participants played a videogame designed to evoke anger. Emotion responses were measured with a multi-modal assessment of self-reported affect, psychophysiology, and facial expressions. Respiratory sinus arrhythmia (RSA) was used to index ER. The videogame effectively elicited subjective anger, angry facial expressions, and heart rate increases when keys malfunctioned. As hy...
Prior research suggests that a traitlike tendency to experience impulsivity during states of high... more Prior research suggests that a traitlike tendency to experience impulsivity during states of high emotion is robustly associated with many forms of psychopathology. Several studies tie emotion‐related impulsivity to response inhibition deficits, but these studies have not focused on the role of emotion or arousal within subjects. The present study tested whether arousal, measured by pupil dilation, amplifies deficits in response inhibition for those high in emotion‐related impulsivity. Participants (N = 85) completed a measure of emotion‐related impulsivity, underwent a positive mood induction procedure that reduced heterogeneity in mood states, and completed a response inhibition task. Pupil dilation was used to index arousal during the response inhibition task. Generalized linear mixed effect modeling yielded the hypothesized interaction between arousal (pupil dilation) and emotion‐related impulsivity in predicting response inhibition performance at the trial level. Emotion‐relate...
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Papers by SheriL Johnson