Background Patient-specific lung mechanics during mechanical ventilation (MV) can be identified f... more Background Patient-specific lung mechanics during mechanical ventilation (MV) can be identified from measured waveforms of fully ventilated, sedated patients. However, asynchrony due to spontaneous breathing (SB) effort can be common, altering these waveforms and reducing the accuracy of identified, model-based, and patient-specific lung mechanics. Methods Changes in patient-specific lung elastance over a pressure–volume (PV) loop, identified using hysteresis loop analysis (HLA), are used to detect the occurrence of asynchrony and identify its type and pattern. The identified HLA parameters are then combined with a nonlinear mechanics hysteresis loop model (HLM) to extract and reconstruct ventilated waveforms unaffected by asynchronous breaths. Asynchrony magnitude can then be quantified using an energy-dissipation metric, Easyn, comparing PV loop area between model-reconstructed and original, altered asynchronous breathing cycles. Performance is evaluated using both test-lung exper...
15 pilot episodes (1168 hours) using STAR at Kálmán Pándy Hospital (Gyula, Hungary) are directly ... more 15 pilot episodes (1168 hours) using STAR at Kálmán Pándy Hospital (Gyula, Hungary) are directly compared to 38 episodes (3763 hours) in Christchurch Hospital. Only patients with a target range of 4.4 8.0 mmol/L were included. Performance is assessed by percentage of (hourly re-sampled) BG measurements in glycaemic bands. Safety is assessed by numbers of patients with severe hypoglycaemia (BG < 2.2mmol/L) and degree of mild hypoglycaemia (%BG<4.0mmol/L). Clinical effort is assessed as average BG measurements per day.
15 pilot episodes (1168 hours) using STAR at Kálmán Pándy Hospital (Gyula, Hungary) are directly ... more 15 pilot episodes (1168 hours) using STAR at Kálmán Pándy Hospital (Gyula, Hungary) are directly compared to 38 episodes (3763 hours) in Christchurch Hospital. Only patients with a target range of 4.4 8.0 mmol/L are included. Performance is assessed by percentage of (hourly re-sampled) BG measurements in glycemic bands. Safety is assessed by numbers of patients with severe hypoglycemia (BG < 2.2mmol/L) and degree of mild hypoglycemia (%BG<4.0mmol/L). Clinical effort is assessed as average BG measurements per day.
The objective of this study was to analyse the effectiveness of some parameters which characteris... more The objective of this study was to analyse the effectiveness of some parameters which characterise the change in morphology in human root canals subjected to ProTaper rotary enlargement with the help of an X-ray microfocus computed tomography (MCT) and to introduce a novel parameter that is effective in quantifying changes in root canal morphology. Ten each straight and curved root canals with mature apices chosen from extracted human upper incisor and canine teeth were scanned with MCT before and after canal shaping using ProTaper rotary instruments in order to facilitate three-dimensional digital reconstruction and quantitative gauging of relevant instrumental parameters and changes therein (surface area and volume). Root canal geometry change and the effectiveness of shaping were quantified with Structure Model Index change (ΔSMI) and surface area change to volume change ratio (ΔSA/ΔV). These two parameters were also tested on simulated canals. Postinstrumentation cross-sectional...
Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 1998
In medical-biological research, the need for an exact mathematical method is being felt more and ... more In medical-biological research, the need for an exact mathematical method is being felt more and more. The Biomedical Engineering Education Programme (BMEEP) in Hungary includes all theoretical processes allowing one to describe the behaviour of a biological system by means of a mathematical model. This paper first deals with the objectives of biomedical engineering training (general principles, etc.); then the
Background Patient-specific lung mechanics during mechanical ventilation (MV) can be identified f... more Background Patient-specific lung mechanics during mechanical ventilation (MV) can be identified from measured waveforms of fully ventilated, sedated patients. However, asynchrony due to spontaneous breathing (SB) effort can be common, altering these waveforms and reducing the accuracy of identified, model-based, and patient-specific lung mechanics. Methods Changes in patient-specific lung elastance over a pressure–volume (PV) loop, identified using hysteresis loop analysis (HLA), are used to detect the occurrence of asynchrony and identify its type and pattern. The identified HLA parameters are then combined with a nonlinear mechanics hysteresis loop model (HLM) to extract and reconstruct ventilated waveforms unaffected by asynchronous breaths. Asynchrony magnitude can then be quantified using an energy-dissipation metric, Easyn, comparing PV loop area between model-reconstructed and original, altered asynchronous breathing cycles. Performance is evaluated using both test-lung exper...
15 pilot episodes (1168 hours) using STAR at Kálmán Pándy Hospital (Gyula, Hungary) are directly ... more 15 pilot episodes (1168 hours) using STAR at Kálmán Pándy Hospital (Gyula, Hungary) are directly compared to 38 episodes (3763 hours) in Christchurch Hospital. Only patients with a target range of 4.4 8.0 mmol/L were included. Performance is assessed by percentage of (hourly re-sampled) BG measurements in glycaemic bands. Safety is assessed by numbers of patients with severe hypoglycaemia (BG < 2.2mmol/L) and degree of mild hypoglycaemia (%BG<4.0mmol/L). Clinical effort is assessed as average BG measurements per day.
15 pilot episodes (1168 hours) using STAR at Kálmán Pándy Hospital (Gyula, Hungary) are directly ... more 15 pilot episodes (1168 hours) using STAR at Kálmán Pándy Hospital (Gyula, Hungary) are directly compared to 38 episodes (3763 hours) in Christchurch Hospital. Only patients with a target range of 4.4 8.0 mmol/L are included. Performance is assessed by percentage of (hourly re-sampled) BG measurements in glycemic bands. Safety is assessed by numbers of patients with severe hypoglycemia (BG < 2.2mmol/L) and degree of mild hypoglycemia (%BG<4.0mmol/L). Clinical effort is assessed as average BG measurements per day.
The objective of this study was to analyse the effectiveness of some parameters which characteris... more The objective of this study was to analyse the effectiveness of some parameters which characterise the change in morphology in human root canals subjected to ProTaper rotary enlargement with the help of an X-ray microfocus computed tomography (MCT) and to introduce a novel parameter that is effective in quantifying changes in root canal morphology. Ten each straight and curved root canals with mature apices chosen from extracted human upper incisor and canine teeth were scanned with MCT before and after canal shaping using ProTaper rotary instruments in order to facilitate three-dimensional digital reconstruction and quantitative gauging of relevant instrumental parameters and changes therein (surface area and volume). Root canal geometry change and the effectiveness of shaping were quantified with Structure Model Index change (ΔSMI) and surface area change to volume change ratio (ΔSA/ΔV). These two parameters were also tested on simulated canals. Postinstrumentation cross-sectional...
Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 1998
In medical-biological research, the need for an exact mathematical method is being felt more and ... more In medical-biological research, the need for an exact mathematical method is being felt more and more. The Biomedical Engineering Education Programme (BMEEP) in Hungary includes all theoretical processes allowing one to describe the behaviour of a biological system by means of a mathematical model. This paper first deals with the objectives of biomedical engineering training (general principles, etc.); then the
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