A number of conjugates tend to self-associate in a transient or permanent fashion and this has fo... more A number of conjugates tend to self-associate in a transient or permanent fashion and this has formed the basis of considerable intense scientific and commercial investigation over recent years. This article considers a variety of strategic formulations, their flaws and advantages. Working practices and groundbreaking developmental activities within the sphere of self-assembling drug conjugates are also reviewed.
Colloids and Surfaces A: Physicochemical and Engineering Aspects, Aug 1, 1996
The potential for cations to cross-link protein molecules through electrostatic interaction and t... more The potential for cations to cross-link protein molecules through electrostatic interaction and thereby enhance foaming properties was investigated using aluminium chloride, β-lactoglobulin and Tween 20 as a model system. The addition of the trivalent cations resulted in a noticable improvement in the foamability and foam stability. Optimal behaviour, specific to the protein and emulsifier concentrations used, was observed at 4–5 μM added aluminium ions. The mode of action of the cations was investigated further using isolated foam lamellae (thin liquid films). The appearance of aggregates in the thin liquid films, non-uniformity of the film, and an increase in the dilational viscosity/elastic modulus of the surface associated with the addition of aluminium cations have contributed to the development of a phenomenological model which explains the observed increase in foam stability.
Rheology is an enormously far-reaching branch of physics (or physical chemistry) and has a number... more Rheology is an enormously far-reaching branch of physics (or physical chemistry) and has a number of different guises. Rheological descriptions define fluids, semi-solids and conventional solids, and the application of this science defines the performance and utility of materials and substances as diverse as foods (such as yogurt and marmalade), body tissues (such as blood, skin and bone) and civil and mechanical engineering materials (such as glass, iron girders and copper wire). Two of the most commonly used terms are viscosity and elasticity, and in some sense these are exact opposites, in which energy put in is either dissipated or stored, respectively. Other useful rheological terms include brittleness, stiffness and stickiness. The experiments considered, described and explained in this article represent accessible manifestations of this rather complex branch of science.
A number of conjugates tend to self-associate in a transient or permanent fashion and this has fo... more A number of conjugates tend to self-associate in a transient or permanent fashion and this has formed the basis of considerable intense scientific and commercial investigation over recent years. This article considers a variety of strategic formulations, their flaws and advantages. Working practices and groundbreaking developmental activities within the sphere of self-assembling drug conjugates are also reviewed.
Colloids and Surfaces A: Physicochemical and Engineering Aspects, Aug 1, 1996
The potential for cations to cross-link protein molecules through electrostatic interaction and t... more The potential for cations to cross-link protein molecules through electrostatic interaction and thereby enhance foaming properties was investigated using aluminium chloride, β-lactoglobulin and Tween 20 as a model system. The addition of the trivalent cations resulted in a noticable improvement in the foamability and foam stability. Optimal behaviour, specific to the protein and emulsifier concentrations used, was observed at 4–5 μM added aluminium ions. The mode of action of the cations was investigated further using isolated foam lamellae (thin liquid films). The appearance of aggregates in the thin liquid films, non-uniformity of the film, and an increase in the dilational viscosity/elastic modulus of the surface associated with the addition of aluminium cations have contributed to the development of a phenomenological model which explains the observed increase in foam stability.
Rheology is an enormously far-reaching branch of physics (or physical chemistry) and has a number... more Rheology is an enormously far-reaching branch of physics (or physical chemistry) and has a number of different guises. Rheological descriptions define fluids, semi-solids and conventional solids, and the application of this science defines the performance and utility of materials and substances as diverse as foods (such as yogurt and marmalade), body tissues (such as blood, skin and bone) and civil and mechanical engineering materials (such as glass, iron girders and copper wire). Two of the most commonly used terms are viscosity and elasticity, and in some sense these are exact opposites, in which energy put in is either dissipated or stored, respectively. Other useful rheological terms include brittleness, stiffness and stickiness. The experiments considered, described and explained in this article represent accessible manifestations of this rather complex branch of science.
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Papers by Dipak K Sarker