Medical Image Computing and Computer-Assisted Intervention���MICCAI 2004, 2004
We describe work toward creating color rapid prototyping (RP) plaster models as visualization too... more We describe work toward creating color rapid prototyping (RP) plaster models as visualization tools to support scientific research in diffusion-tensor (DT) MRI analysis. We currently give surgeons and neurologists virtual-reality (VR) applications to visualize different aspects of their brain data, but having physical representations of those virtual models allows them to review the data with a very robust, natural, and fast haptic interface: their own hands. Our initial results are encouraging, and end users are excited about the ...
A prototype cortical neural interface microsystem has been developed for brain implantable neuroe... more A prototype cortical neural interface microsystem has been developed for brain implantable neuroengineering applications, featuring hybrid RF (radio-frequency) inductive and IR (infrared) optical telemetries. The system is aimed at neural recording from primates by converting cortical signals to a digital stream of IR light pulses, while acquiring clock signal and electrical power through RF induction. The implantable unit employs a flexible LCP (liquid crystal polymer) substrate for integration of analog, digital, and optoelectronic components, while adapting to the anatomical and physiological constraints of the environment. An ultra-low power analog CMOS chip, which includes preamplifier and multiplexing circuitry, is directly flip-chip bonded to the microelectrode array to form the immediate cortical neuroprobe device. A 16-channel version of the probe has been tested in various in-vivo animal experiments, including measurements of neural activity in somatosensory cortex of a rat.
While paying homage to the technological revolutions empowered by mod-ern microelectronics and th... more While paying homage to the technological revolutions empowered by mod-ern microelectronics and the continued march towards ever increasing so-phistication of nanoscale high-density digital circuits, it may be useful to pause and draw a reference to a computer of very ...
Recent advances in functional electrical stimulation (FES) show significant promise for restoring... more Recent advances in functional electrical stimulation (FES) show significant promise for restoring voluntary movement in patients with paralysis or other severe motor impairments. Current approaches for implantable FES systems involve multisite stimulation, posing research issues related to their physical size, power and signal delivery, surgical and safety challenges. To explore a different means for delivering the stimulus to a distant muscle nerve site, we have elicited in vitro FES response using a high efficiency microcrystal photovoltaic device as a neurostimulator, integrated with a biocompatible glass optical fiber which forms a lossless, interference-free lightwave conduit for signal and energy transport. As a proof of concept demonstration, a sciatic nerve of a frog is stimulated by the microcrystal device connected to a multimode optical fiber (core diameter of 62.5 microm), which converts optical activation pulses ( approximately 100 micros) from an infrared semiconductor laser source (at 852 nm wavelength) into an FES signal.
Medical Image Computing and Computer-Assisted Intervention���MICCAI 2004, 2004
We describe work toward creating color rapid prototyping (RP) plaster models as visualization too... more We describe work toward creating color rapid prototyping (RP) plaster models as visualization tools to support scientific research in diffusion-tensor (DT) MRI analysis. We currently give surgeons and neurologists virtual-reality (VR) applications to visualize different aspects of their brain data, but having physical representations of those virtual models allows them to review the data with a very robust, natural, and fast haptic interface: their own hands. Our initial results are encouraging, and end users are excited about the ...
A prototype cortical neural interface microsystem has been developed for brain implantable neuroe... more A prototype cortical neural interface microsystem has been developed for brain implantable neuroengineering applications, featuring hybrid RF (radio-frequency) inductive and IR (infrared) optical telemetries. The system is aimed at neural recording from primates by converting cortical signals to a digital stream of IR light pulses, while acquiring clock signal and electrical power through RF induction. The implantable unit employs a flexible LCP (liquid crystal polymer) substrate for integration of analog, digital, and optoelectronic components, while adapting to the anatomical and physiological constraints of the environment. An ultra-low power analog CMOS chip, which includes preamplifier and multiplexing circuitry, is directly flip-chip bonded to the microelectrode array to form the immediate cortical neuroprobe device. A 16-channel version of the probe has been tested in various in-vivo animal experiments, including measurements of neural activity in somatosensory cortex of a rat.
While paying homage to the technological revolutions empowered by mod-ern microelectronics and th... more While paying homage to the technological revolutions empowered by mod-ern microelectronics and the continued march towards ever increasing so-phistication of nanoscale high-density digital circuits, it may be useful to pause and draw a reference to a computer of very ...
Recent advances in functional electrical stimulation (FES) show significant promise for restoring... more Recent advances in functional electrical stimulation (FES) show significant promise for restoring voluntary movement in patients with paralysis or other severe motor impairments. Current approaches for implantable FES systems involve multisite stimulation, posing research issues related to their physical size, power and signal delivery, surgical and safety challenges. To explore a different means for delivering the stimulus to a distant muscle nerve site, we have elicited in vitro FES response using a high efficiency microcrystal photovoltaic device as a neurostimulator, integrated with a biocompatible glass optical fiber which forms a lossless, interference-free lightwave conduit for signal and energy transport. As a proof of concept demonstration, a sciatic nerve of a frog is stimulated by the microcrystal device connected to a multimode optical fiber (core diameter of 62.5 microm), which converts optical activation pulses ( approximately 100 micros) from an infrared semiconductor laser source (at 852 nm wavelength) into an FES signal.
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