Despite these many applications for microfluidics in augmenting the synthetic biology workflow, a... more Despite these many applications for microfluidics in augmenting the synthetic biology workflow, adoption of microfluidics as a potential experimental and test platform has been slow in the synthetic biology community at large. The majority of synthetic biologists lack both the expertise knowledge in fluid dynamics and microfluidic design and the expensive capital equipment for microfluidic fabrication. Layout of microfluidic designs by hand is both time consuming and error prone. In addition, experiments involving mLSI also require a complex control platform including both software and hardware for valve control and fluid manipulation. Such setups are frequently customized for the application at hand and may be difficult to claim for future reuse. Improvements in automation for microfluidic device design and readily available open source software and hardware for control platforms could increase the speed of adoption of microfluidic technologies by synthetic biologists. In [3] the a...
With microfluidic large scale integration and the emergence of many new synthetic biology technol... more With microfluidic large scale integration and the emergence of many new synthetic biology technologies, there is an ever increasing benefit in using computer automated design (CAD) tools for scaling designs to larger and more complex applications. In 2015 Xin Han et al. demonstrated the effective delivery of CRISPR-Cas9 to cells, which are normally difficult to transfect, using a microfluidic membrane device. To help researchers and engineers realize microfluidics for new synthetic biology applications, it is pertinent that they have access to CAD tools to facilitate the design process. Fluigi Cloud is an online platform designed with this goal in mind. It provides a suite of software tools for microfluidic CAD. This work describes some applications of Fluigi Cloud and the role it plays in the greater ecosystem of microfluidic design and synthetic biology
This article was accepted and presented at the 9th International Workshop on Bio-Design Automatio... more This article was accepted and presented at the 9th International Workshop on Bio-Design Automation, Pittsburgh, Pennsylvania (2017).
The design of microfluidic Lab on a Chip (LoC) systems is an onerous task requiring specialized s... more The design of microfluidic Lab on a Chip (LoC) systems is an onerous task requiring specialized skills in fluid dynamics, mechanical design drafting, and manufacturing. Engineers face significant challenges during the labor-intensive process of designing microfluidic devices, with very few specialized tools that help automate the process. Typical design iterations require the engineer to research the architecture, manually draft the device layout, optimize for manufacturing processes, and manually calculate and program the valve sequences that operate the microfluidic device. The problem compounds when engineers not only have to test the functionality of the chip but are also expected to optimize them for the robust execution of biological assays. In this paper, we present an interactive tool for designing continuous flow microfluidic devices. 3DμF is the first completely open source interactive microfluidic system designer that readily supports state of the art design automation al...
The design of microfluidic Lab on a Chip (LoC) systems is an onerous task requiring specialized s... more The design of microfluidic Lab on a Chip (LoC) systems is an onerous task requiring specialized skills in fluid dynamics, mechanical design drafting, and manufacturing. Engineers face significant challenges during the labor-intensive process of designing microfluidic devices, with very few specialized tools that help automate the process. Typical design iterations require the engineer to research the architecture, manually draft the device layout, optimize for manufacturing processes, and manually calculate and program the valve sequences that operate the microfluidic device. The problem compounds when engineers not only have to test the functionality of the chip but are also expected to optimize them for the robust execution of biological assays. In this paper, we present an interactive tool for designing continuous flow microfluidic devices. 3DμF is the first completely open source interactive microfluidic system designer that readily supports state of the art design automation algorithms. Through various case studies, we show 3DμF can be used to reproduce designs from literature, provide metrics for evaluating microfluidic design complexity and showcase how 3DμF is a platform for integrating a wide assortment of engineering techniques used in the design of microfluidic devices as a part of the standard design workflow.
The design of microfluidic Lab on a Chip (LoC) systems is an onerous task requiring specialized s... more The design of microfluidic Lab on a Chip (LoC) systems is an onerous task requiring specialized skills in fluid dynamics, mechanical design drafting, and manufacturing. Engineers face significant challenges during the labor-intensive process of designing microfluidic devices, with very few specialized tools that help automate the process. Typical design iterations require the engineer to research the architecture, manually draft the device layout, optimize for manufacturing processes, and manually calculate and program the valve sequences that operate the microfluidic device. The problem compounds when engineers not only have to test the functionality of the chip but are also expected to optimize them for the robust execution of biological assays. In this paper, we present an interactive tool for designing continuous flow microfluidic devices. 3DμF is the first completely open source interactive microfluidic system designer that readily supports state of the art design automation algorithms. Through various case studies, we show 3DμF can be used to reproduce designs from literature, provide metrics for evaluating microfluidic design complexity and showcase how 3DμF is a platform for integrating a wide assortment of engineering techniques used in the design of microfluidic devices as a part of the standard design workflow.
This paper examines the stop light effect of a waveguide nanostructure using ITO-SI-ITO as the
pr... more This paper examines the stop light effect of a waveguide nanostructure using ITO-SI-ITO as the propagating medium. The paper attempts to evaluate the validity of a previously published article. By numerically anazyling the same structure while including material dispersion, the paper paves way for future work in this area.
A literature review is done on silicon photonic contra-DCs and their applications in optical com-... more A literature review is done on silicon photonic contra-DCs and their applications in optical com-
munications, which significantly improves the state of the art in integrated Bragg filters and brings
about unlimited scalability of WDM channels. These wide-band WDM filters are very tolerant
to temperature fluctuations (up to 50 C), which may significantly reduce power consumption of
silicon photonic WDM links. Replacing two-port Bragg gratings with contra-DCs allows for direct
integration (i.e., without using circulators) with other photonic devices such as lasers and modula-
tors, as well as combining these functions to realize on-chip optical signal processors and photonic
microwave systems.The results show that contra-DCs are promising for large-scale integration of
various Bragg-grating defined functions on silicon.
Despite these many applications for microfluidics in augmenting the synthetic biology workflow, a... more Despite these many applications for microfluidics in augmenting the synthetic biology workflow, adoption of microfluidics as a potential experimental and test platform has been slow in the synthetic biology community at large. The majority of synthetic biologists lack both the expertise knowledge in fluid dynamics and microfluidic design and the expensive capital equipment for microfluidic fabrication. Layout of microfluidic designs by hand is both time consuming and error prone. In addition, experiments involving mLSI also require a complex control platform including both software and hardware for valve control and fluid manipulation. Such setups are frequently customized for the application at hand and may be difficult to claim for future reuse. Improvements in automation for microfluidic device design and readily available open source software and hardware for control platforms could increase the speed of adoption of microfluidic technologies by synthetic biologists. In [3] the a...
With microfluidic large scale integration and the emergence of many new synthetic biology technol... more With microfluidic large scale integration and the emergence of many new synthetic biology technologies, there is an ever increasing benefit in using computer automated design (CAD) tools for scaling designs to larger and more complex applications. In 2015 Xin Han et al. demonstrated the effective delivery of CRISPR-Cas9 to cells, which are normally difficult to transfect, using a microfluidic membrane device. To help researchers and engineers realize microfluidics for new synthetic biology applications, it is pertinent that they have access to CAD tools to facilitate the design process. Fluigi Cloud is an online platform designed with this goal in mind. It provides a suite of software tools for microfluidic CAD. This work describes some applications of Fluigi Cloud and the role it plays in the greater ecosystem of microfluidic design and synthetic biology
This article was accepted and presented at the 9th International Workshop on Bio-Design Automatio... more This article was accepted and presented at the 9th International Workshop on Bio-Design Automation, Pittsburgh, Pennsylvania (2017).
The design of microfluidic Lab on a Chip (LoC) systems is an onerous task requiring specialized s... more The design of microfluidic Lab on a Chip (LoC) systems is an onerous task requiring specialized skills in fluid dynamics, mechanical design drafting, and manufacturing. Engineers face significant challenges during the labor-intensive process of designing microfluidic devices, with very few specialized tools that help automate the process. Typical design iterations require the engineer to research the architecture, manually draft the device layout, optimize for manufacturing processes, and manually calculate and program the valve sequences that operate the microfluidic device. The problem compounds when engineers not only have to test the functionality of the chip but are also expected to optimize them for the robust execution of biological assays. In this paper, we present an interactive tool for designing continuous flow microfluidic devices. 3DμF is the first completely open source interactive microfluidic system designer that readily supports state of the art design automation al...
The design of microfluidic Lab on a Chip (LoC) systems is an onerous task requiring specialized s... more The design of microfluidic Lab on a Chip (LoC) systems is an onerous task requiring specialized skills in fluid dynamics, mechanical design drafting, and manufacturing. Engineers face significant challenges during the labor-intensive process of designing microfluidic devices, with very few specialized tools that help automate the process. Typical design iterations require the engineer to research the architecture, manually draft the device layout, optimize for manufacturing processes, and manually calculate and program the valve sequences that operate the microfluidic device. The problem compounds when engineers not only have to test the functionality of the chip but are also expected to optimize them for the robust execution of biological assays. In this paper, we present an interactive tool for designing continuous flow microfluidic devices. 3DμF is the first completely open source interactive microfluidic system designer that readily supports state of the art design automation algorithms. Through various case studies, we show 3DμF can be used to reproduce designs from literature, provide metrics for evaluating microfluidic design complexity and showcase how 3DμF is a platform for integrating a wide assortment of engineering techniques used in the design of microfluidic devices as a part of the standard design workflow.
The design of microfluidic Lab on a Chip (LoC) systems is an onerous task requiring specialized s... more The design of microfluidic Lab on a Chip (LoC) systems is an onerous task requiring specialized skills in fluid dynamics, mechanical design drafting, and manufacturing. Engineers face significant challenges during the labor-intensive process of designing microfluidic devices, with very few specialized tools that help automate the process. Typical design iterations require the engineer to research the architecture, manually draft the device layout, optimize for manufacturing processes, and manually calculate and program the valve sequences that operate the microfluidic device. The problem compounds when engineers not only have to test the functionality of the chip but are also expected to optimize them for the robust execution of biological assays. In this paper, we present an interactive tool for designing continuous flow microfluidic devices. 3DμF is the first completely open source interactive microfluidic system designer that readily supports state of the art design automation algorithms. Through various case studies, we show 3DμF can be used to reproduce designs from literature, provide metrics for evaluating microfluidic design complexity and showcase how 3DμF is a platform for integrating a wide assortment of engineering techniques used in the design of microfluidic devices as a part of the standard design workflow.
This paper examines the stop light effect of a waveguide nanostructure using ITO-SI-ITO as the
pr... more This paper examines the stop light effect of a waveguide nanostructure using ITO-SI-ITO as the propagating medium. The paper attempts to evaluate the validity of a previously published article. By numerically anazyling the same structure while including material dispersion, the paper paves way for future work in this area.
A literature review is done on silicon photonic contra-DCs and their applications in optical com-... more A literature review is done on silicon photonic contra-DCs and their applications in optical com-
munications, which significantly improves the state of the art in integrated Bragg filters and brings
about unlimited scalability of WDM channels. These wide-band WDM filters are very tolerant
to temperature fluctuations (up to 50 C), which may significantly reduce power consumption of
silicon photonic WDM links. Replacing two-port Bragg gratings with contra-DCs allows for direct
integration (i.e., without using circulators) with other photonic devices such as lasers and modula-
tors, as well as combining these functions to realize on-chip optical signal processors and photonic
microwave systems.The results show that contra-DCs are promising for large-scale integration of
various Bragg-grating defined functions on silicon.
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Papers by Radhakrishna Sanka
propagating medium. The paper attempts to evaluate the validity of a previously published article.
By numerically anazyling the same structure while including material dispersion, the paper paves
way for future work in this area.
munications, which significantly improves the state of the art in integrated Bragg filters and brings
about unlimited scalability of WDM channels. These wide-band WDM filters are very tolerant
to temperature fluctuations (up to 50 C), which may significantly reduce power consumption of
silicon photonic WDM links. Replacing two-port Bragg gratings with contra-DCs allows for direct
integration (i.e., without using circulators) with other photonic devices such as lasers and modula-
tors, as well as combining these functions to realize on-chip optical signal processors and photonic
microwave systems.The results show that contra-DCs are promising for large-scale integration of
various Bragg-grating defined functions on silicon.
propagating medium. The paper attempts to evaluate the validity of a previously published article.
By numerically anazyling the same structure while including material dispersion, the paper paves
way for future work in this area.
munications, which significantly improves the state of the art in integrated Bragg filters and brings
about unlimited scalability of WDM channels. These wide-band WDM filters are very tolerant
to temperature fluctuations (up to 50 C), which may significantly reduce power consumption of
silicon photonic WDM links. Replacing two-port Bragg gratings with contra-DCs allows for direct
integration (i.e., without using circulators) with other photonic devices such as lasers and modula-
tors, as well as combining these functions to realize on-chip optical signal processors and photonic
microwave systems.The results show that contra-DCs are promising for large-scale integration of
various Bragg-grating defined functions on silicon.