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CeTICS - Centro de Toxinas, Imuno-Resposta e Sinalização Celular

Processo: 13/07467-1
Modalidade de apoio:Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Vigência: 01 de julho de 2013 - 30 de junho de 2026
Área do conhecimento:Ciências Biológicas - Bioquímica - Biologia Molecular
Pesquisador responsável:Hugo Aguirre Armelin
Beneficiário:Hugo Aguirre Armelin
Instituição Sede: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brasil
Pesquisadores principais:
( Atuais )		Denise Vilarinho Tambourgi ; Gisele Picolo ; Inácio de Loiola Meirelles Junqueira de Azevedo ; Monica Valdyrce dos Anjos Lopes Ferreira ; Solange Maria de Toledo Serrano ; Wilmar Dias da Silva
Pesquisadores principais:
( Anteriores )		Ana Marisa Chudzinski-Tavassi ; Junior Barrera ; Maria Carolina Quartim Barbosa Elias Sabbaga ; Osvaldo Augusto Brazil Esteves Sant'Anna ; Yara Cury
Pesquisadores associados:Adriana Mortara Almeida ; Alessandra Fernandes Bizerra ; Alexandre Keiji Tashima ; Aline Soriano Lopes ; Allan Mowat ; Ana Maria Moura da Silva ; Ana Marisa Chudzinski-Tavassi ; André Zelanis Palitot Pereira ; Ann Ager ; B. Paul Morgan ; Carla Cristina Squaiella ; Carla Lima da Silva ; Carmen W. Van Den Berg ; Daria Mochly-Rosen ; Denise Vilarinho Tambourgi ; Fabio Carlos Magnoli ; Fábio Nakano ; Fan Hui Wen ; Fernanda Calheta Vieira Portaro ; Fernanda Faria ; Fernanda Paiva Guimarães ; Gisele Picolo ; Giselle Pidde Marques Porto ; Inácio de Loiola Meirelles Junqueira de Azevedo ; Jay W. Fox ; Jesus Aparecido Ferro ; Jose Roberto Marcelino ; Jose Salvatore Leister Patane ; Julia Pinheiro Chagas da Cunha ; Katsuhiro Konno ; Kerly Fernanda Mesquita Pasqualoto ; Leo Kei Iwai ; Luc Pellerin ; Luciana Rodrigues Gomes ; Luiz Vicente Rizzo ; Marcella Barbosa Faria de Almeida Prado ; Marcelo da Silva Reis ; Marcelo de Franco ; Marcia Carvalho de Abreu Fantini ; Marcio Henrique Zaim ; Maria Carolina Quartim Barbosa Elias Sabbaga ; Maria Teresa Machini ; Marinilce Fagundes dos Santos ; Martha Marandino ; Miguel Allende ; Milton Yutaka Nishiyama Junior ; Mirta Schattner ; Miryam Paola Alvarez Flores ; Ovidiu Radulescu ; Paulo Lee Ho ; Paulo Sérgio Lacerda Beirão ; Pedro Ismael da Silva Junior ; Ricardo Jose Giordano ; Richard Mcculloch ; Robson Lopes de Melo ; Roger Chammas ; Ruy Gastaldoni Jaeger ; Sandra Coccuzzo Sampaio Vessoni ; Silvio Roberto de Azevedo Salinas ; Simone Guedes Calderano ; Sonia Aparecida de Andrade Chudzinski ; Tânia Tomé Martins de Castro ; Vanessa Olzon Zambelli ; Vanessa Rioli
Auxílios(s) vinculado(s):20/01360-4 - Evolução do veneno de serpentes avançadas da América do Sul: uma abordagem integrada comparando linhagens cis-/trans-andinas, AV.EXT
22/10539-3 - EMU concedido no processo FAPESP 2013/07467-1: nome do equipamento: QuantStudio 3 Real-Time PCR System, Applied Biosystems, AP.EMU
19/23605-1 - Identificação de mecanismos moleculares de resistência a drogas e reparação de DNA em Trypanosomatidae, AP.R SPRINT
 + mais auxílios vinculados 21/13951-0 - EMU concedido no processo 13/07467-1 : Citômetro de Fluxo BD FACSLyric e acessórios, AP.EMU
21/13939-0 - EMU concedido no processo Fapesp 13/07467-1: Espectrômetro de Massas Orbitrap Exploris 480 e acessórios, AP.EMU
19/07809-6 - ICOM CECA Conference 2019: Roles of Museum Education: Supporting Self and Society, AR.EXT
18/26586-5 - 24o Congresso Mundial de Dermatologia, AR.EXT
17/18281-7 - EMU concedido no processo CEPID 2013/07467-1 - nome do equipamento: sistema NanoLC EASY-nLCTM 1000 - thermo scientific, AP.EMU
15/10413-6 - ICOM CECA Annual Conference 2015: Museum Education and Accessibility: Bridging the Gaps, AR.EXT
15/07553-0 - EMU concedido no processo 2013/07467-1: sistema de ressonância plasmônica de superfície - Biacore T200, AP.EMU
15/10037-4 - EMU concedido no processo 2013/07467-1: citômetro de fluxo, AP.EMU - menos auxílios vinculados
Bolsa(s) vinculada(s):24/17031-0 - Contribuições do Sistema Complemento e Células Endoteliais na Imunopatologia dos Envenenamentos por Abelhas Africanizadas (Apis mellifera), BP.PD
24/14508-0 - Apoio técnico aos projetos de genômica do CeTICS: sequenciamento e montagem de genomas ofídicos, BP.TT
24/09407-0 - Nova proposta terapêutica para o câncer: combinação de mitogeno com um inibidor de via de estresse celular., BP.PD
 + mais bolsas vinculadas 24/09408-7 - Explorar o balanço entre ativação mitogênica e inibição de vias de estresse em células cancerígenas e normais, BP.PD
24/03396-7 - Aprendizagem profunda para predição e caracterização estrutural de toxinas glicosiladas de serpentes do gênero Bothrops, BP.DD
23/17619-5 - O veneno de Bothrops jararaca e a falência renal: bases moleculares da toxicidade sobre células mesangiais e tecido renal murino, do efeito sinérgico de produtos de degradação de proteínas plasmáticas, e o papel de catepsinas, BP.DD
23/12213-0 - Gerenciamento e Implementação de novas ferramentas para a plataforma CeTICSDB., BP.TT
23/10147-0 - Avaliação dos mecanismos moleculares de Natterina-like XP_017212453.1 que facilitam a ativação do inflamassoma em larvas de zebrafish, BP.PD
23/08327-0 - O veneno de Bothrops jararaca e o dano tecidual: análise proteômica e peptidômica da toxicidade em fibroblastos humanos., BP.IC
23/01659-8 - Avaliação da ativação do inflamassoma pela proteína Natterina-like codificada pelo gene loc795232 em zebrafish, BP.MS
23/00140-9 - Análise proteômica de pulmão de camundongos sob o efeito da peçonha de Crotalus durissus terrificus, BP.IC
23/04095-8 - Gerenciamento e Implementação de novas ferramentas para a plataforma CeTICSDB, BP.TT
22/07209-1 - O veneno de Bothrops jararaca e a falência renal: bases moleculares da citotoxicidade em células mesangiais e do efeito sinérgico de produtos de degradação de proteínas plasmáticas., BP.MS
22/16146-3 - Caracterização molecular dos efeitos do veneno de Bothrops jararaca: análise de células pulmonares em cultura e tecido pulmonar de camundongo por abordagens proteômica e imuno-histoquímica., BP.PD
22/10761-8 - Influência da tríade, grupo heme/sistema complemento/inflamação, na imunopatogênese do envenenamento por abelhas africanizadas, BP.TT
21/10570-5 - Caracterização molecular dos efeitos in vivo do veneno da Bothrops jararaca: análises do tecido muscular e do plasma de camundongos, por abordagens de proteômica e imuno-histoquímica, BP.PD
21/10344-5 - Identificação de peptídeos derivados da crotoxina com potencial antitumoral e imunomodulatório, BP.PD
19/24580-2 - Seleção bayesiana de modelos dinâmicos de vias não isoladas de sinalização celular, BP.DD
21/08891-8 - Avaliação dos mecanismos farmacológicos do peptídeo TnP isolado do veneno de Thalassophryne nattereri na terapêutica da Retinopatia Hipóxica em Zebrafish, BP.PD
21/04355-4 - Implementações eficientes de métodos Bayesianos para seleção de modelos de vias de sinalização celular, BP.IC
20/11468-7 - Gerenciamento e Implementação de Novas Ferramentas para a Plataforma CeTICSDB, BP.TT
20/12317-2 - Análise proteômica dos efeitos sistêmicos do veneno da Bothrops jararaca em modelo murino., BP.PD
19/27348-3 - Inibição do sistema complemento como meio para controlar a inflamação associada a envenenamentos, BP.PD
20/03718-3 - Compreendendo as reações locais induzidas pelos venenos de Loxosceles e suas principais toxinas, BP.PD
20/00770-4 - Síntese de derivados de benznidazol e óxido de grafeno e avaliação de suas atividades anti-chagásicas, BP.PD
19/27677-7 - Estudo da indução de microRNAs regulatórios por TNP dependente da ativação do receptor de hidrocarboneto arílico (AhR), BP.PD
19/20025-4 - Uma abordagem baseada em computação Bayesiana aproximada para resolver o problema da falta de isolamento na modelagem de vias de sinalização, BE.PQ
19/18565-0 - Avaliação por hibridização in situ quantitativa dos níveis dos transcritos de natterina-like em zebrafish depletados com CRISPR/Cas-9, BP.IC
19/10500-7 - Avaliação da necessidade da ativação do complexo inflamassoma na inflamação neutrofilica induzida pelas natterinas, toxinas formadoras de poros, BE.PQ
19/05882-8 - Avaliação do papel da crotalfina na dinâmica do cílio primário de neurônios aferentes primários: novos caminhos para o estudo de compostos analgésicos, BP.PD
19/13039-9 - Controle do Ciclo Celular em células normais e malignas, nova abordagem na terapia do câncer., BP.PD
19/01895-8 - Função das nucleases MRE11, DNA2 e EXO1 na ressecção do DNA terminal e o reparo das quebras de dupla fita em Trypanosoma brucei, BP.PD
19/02333-3 - Validação da importância funcional das natterinas na resposta imune inata em zebrafish por CRISPR-Cas9, um método de loss-of-function, BP.MS
18/06751-1 - Caracterização molecular dos efeitos in vivo da metaloproteinase hemorrágica HF3: análises do proteoma do tecido muscular de camundongos, BP.MS
18/12364-0 - Expressão, purificação e caracterização inicial de uma nova proteína RPA-like de Trypanosoma brucei, BP.IC
17/07693-2 - Dinâmica funcional da proteína Orc1b durante o ciclo de vida de Trypanosoma, BP.DR
18/08167-5 - Apoio bioinformático aos projetos de análise de expressão gênica diferencial do CeTICS, BP.TT
18/06682-0 - Análise filogenética computacional de serpentes do gênero Bothrops a partir de proteomas de venenos, BP.IC
17/06496-9 - Caracterização proteômica do efeito da peçonha de Bothrops jararaca sobre linhagens celulares de câncer versus linhagens celulares normais, BP.MS
17/18344-9 - Proteômica quantitativa da cromatina frente ao tratamento com FGF2: análise da regulação transcricional e associação de cdc42, BP.DD
17/20575-9 - Identificação de vias de sinalização celular baseada em repositórios de cinética de reações bioquímicas, BP.MS
17/19252-0 - Análise proteômica dos efeitos de PA-BJ, uma serinoproteinase do veneno de Bothrops jararaca, sobre cultura de células endoteliais de sangue periférico, BP.PD
17/19545-8 - Análise dos mecanismos moleculares subjacentes à inibição do ciclo celular por FGF2 em células Y1 adrenocorticais e tumorais de camundongo, dependentes de WT-Kras amplificado, BP.PD
17/13681-7 - Análise e desenvolvimento de ferramentas de bioinformática aplicadas a estudos de genômica, transcriptômica e proteômica, BP.TT
17/09929-3 - Venenos de serpentes do gênero Bothrops: impacto da glicosilação na complexidade dos proteomas e função de toxinas, BP.DD
17/12199-7 - Loxoscelismo: da pesquisa básica ao desenvolvimento de novas terapias, BP.TT
17/09648-4 - Expressão recombinante, e caracterização funcional dos domínios não catalíticos de uma metaloproteinase da classe P-III do veneno da serpente Bothrops jararaca, utilizando um sistema de expressão livre de célula, BP.IC
17/10853-1 - Desenvolvimento de ferramentas e análises para estudo das bases moleculares para a replicação do DNA e ciclo celular, BP.TT
16/25959-7 - Projeto de algoritmos baseados em florestas de posets para o problema de otimização U-curve, BP.IC
16/22774-6 - Controle epigenético na analgesia dependente da ativação de receptores opióides: papel dos miRNAs e metilação do DNA no efeito antinociceptivo da crotalfina, BP.PD
17/02225-0 - Loxoscelismo: da pesquisa básica ao desenvolvimento de novas terapias, BP.TT
16/25661-8 - Desenvolvimento de infraestrutura e ferramentas de análise e integração de dados de genômica e transcriptômica para Bothrops jararaca no projeto CeTICS, BP.TT
17/00715-0 - Enzimas proteolíticas de venenos de serpentes disparam cascatas de eventos moleculares ainda desconhecidos, BP.PD
16/17775-3 - Desenho e simulação de modelos computacionais da dinâmica de replicação de DNA em Kinetoplastídeos, BP.IC
16/22415-6 - Desenvolvimento de infraestrutura e ferramentas de análise e integração de dados de genômica e transcriptômica para Bothrops jararaca no projeto CeTICS, BP.TT
16/16935-7 - Uma perspectiva sobre as modificações pós-traducionais em toxinas de venenos do gênero Bothrops: identificação proteômica de sítios específicos de N-glicanos e cisteínas., BP.DR
15/12224-6 - Avaliação dos mecanismos envolvidos na sobrevivência de células de longa vida produtoras de anticorpos induzida pela IL-17 externalizada em NET (neutrophil extracellular traps), BE.PQ
16/13469-5 - Desenvolvimento de Infraestrutura, ferramentas de análise e integração de dados de genômica e transcriptômica no projeto CeTICS, BP.TT
16/10613-8 - Análise da ação do sistema complemento na expressão de micro RNAs no loxoscelismo sistêmico, BP.PD
16/07802-3 - Concepção de antivenenos com base na sequência de aminoácidos das regiões determinantes de complementaridade (CDRs), BP.PD
15/23691-4 - Ativ pró-inflamatória de proteinases de venenos de serpentes: i) obtenção de proteinases recombinantes em sistema livre de CEL; ii) geração de microvesículas por monócitos estimulados com proteinases nativas e recomb e sua interação com células endoteliais, BP.PD
15/17053-5 - Estudo da ativação de inflamassomas, em queratinócitos humanos, por ação do veneno da aranha Loxosceles laeta e sua esfingomielinase D, BP.PD
15/03509-7 - Sequenciamento genômico de serpentes brasileiras focado no estudo de toxinas, BP.PD
15/17494-1 - Loxoscelism: from basic research to the proposal of new therapies, BP.PD
15/01234-0 - Enzimas proteolíticas de venenos de serpentes disparam cascatas de eventos moleculares ainda desconhecidos, BP.PD
15/04641-6 - Investigação da participação da dessensibilização de receptores no antagonismo das natterinas, BP.IC
14/24170-5 - Dinâmica da replicação do DNA em Trypanosoma cruzi: caracterização do licenciamento e da taxa de replicação, BP.PD
15/03953-4 - Modulação da expressão de integrinas em neutrófilos pelas Natterinas, BP.IC
14/02978-0 - Análise funcional do complexo RPA em Trypanosoma cruzi e seu envolvimento com DNA telomérico, BP.DR
14/23564-0 - Estudos de estruturas de dados eficientes para abordar o problema de otimização U-curve, BP.IC
14/21557-6 - Analise funcional dos homólogos Ataxia-telangiectasia mutated (ATM) e a Ataxia-telangiectasia and RAD3-related (ATR) na sinalização de dano ao DNA em Trypanosoma cruzi, BP.IC
14/18875-6 - Dor e analgesia: mecanismos moleculares de novas drogas terapêuticas e alvos, BP.PD
14/13375-5 - Origens da replicação em tripanossomas, BP.PD
14/01534-1 - Caracterização do potencial de inibição do receptor de colágeno receptor do domínio de Discoidina 2 por componentes de metaloproteinases de venenos de cobra, BE.PQ
13/24212-7 - Bioinformática e modelagem, BP.PD
13/50694-9 - Avaliação do papel dos NET de neutrófilos na diferenciação de células produtoras de anticorpos de longa vida na resposta crônica induzida pelo veneno de Thalassophryne nattereri, BP.PD
13/07974-0 - Sequenciamento do genoma da serpente Bothrops jararaca para caracterização da estrutura gênica de toxinas e seus elementos regulatórios, BP.DR
12/51135-0 - Verificação da indução pelas natterinas de mecanismos reguladores da cascata de sinalização de TLR, BP.PD
12/20186-9 - Mecanismos moleculares da interação funcional entre Ras e ciclina D1 em células malignas dependentes de Ras, BP.PD
11/09333-7 - Crotalfina: análogos fluorescentes e estudo de seu mecanismo de ação em culturas e co-culturas de neurônios e queratinócitos, BP.PD - menos bolsas vinculadas
Assunto(s):Ciclo celular  Homeostase  Toxinas  Genes de resposta imune  Financiamento em saúde 
Palavra(s)-Chave do Pesquisador:biologia sistêmica | ciclo celular | homeostasia | resposta imune | sinalização celular | toxina | Biologia Molecular
Publicação FAPESP:https://media.fapesp.br/bv/uploads/pdfs/Multidisciplinary_science_Ebmcxc8_18_19.pdf

Resumo

No Instituto Butantan toxinologia e regulação da resposta imune são, tradicionalmente, áreas conexas de pesquisa científica e desenvolvimento biotecnológico, através das quais o Instituto, historicamente, construiu sua reputação internacional de excelência. Na cultura do Instituto, venenos são misturas complexas de toxinas, selecionadas ao longo da evolução para sinergicamente exercerem efeitos biológicos sistêmicos, através de mecanismos bioquímicos, moleculares e celulares altamente específicos. Portanto, a análise química de venenos tem boas chances de levar à descoberta de novas moléculas de toxinas com potencial terapêutico. Essas premissas foram seguidas com sucesso por pesquisadores do Centro de Toxinologia Aplicada (CAT CEPID-FAPESP), projeto iniciado há 10 anos, que isolaram, caracterizaram quimicamente e patentearam diversas toxinas de natureza proteica, que se tornaram pontos de partida para desenvolvimento de inovação farmacêutica em parceria com indústrias locais. A ênfase em proteínas e peptídeos levou o CAT CEPID a instalar laboratórios no estado da arte para transcriptômica, proteômica, biologia molecular do DNA recombinante e síntese de peptídeos. Mais recentemente, estudos dos mecanismos de ação, bioquímicas, moleculares e celulares, dessas promissoras moléculas foram iniciados com o objetivo de estabelecer provas de conceito. Assim, o CAT estabeleceu, no Instituto Butantan, as condições iniciais para a criação de um centro de toxinas e resposta imune fundamentado nas abordagens atuais da biologia sistêmica. Por conseguinte, 10 pesquisadores, entre os mais competitivos do Instituto Butantan, propõem a criação do novo Centro de Toxinas, Resposta-imune e Sinalização Celular, com aspirações a centro de excelência de classe mundial, aproveitando a histórica reputação internacional do Butantan e o sucesso recente do CAT CEPID. O Plano de pesquisa do Centro Integra subprojetos voltados para a pesquisa científica com subprojetos de vocação para a inovação tecnológica. Um grande grupo de cientistas seniores do Instituto Butantan, de outras instituições brasileiras e de renomadas instituições estrangeiras serão colaboradores do Centro proposto. (AU)

Matéria(s) publicada(s) na Agência FAPESP sobre o auxílio:
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Publicações científicas (269)
(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)
RUSSO, LILIAN C.; ARAUJO, CHRISTIANE B.; IWAI, LEO K.; FERRO, EMER S.; FORTI, FABIO L.. A Cyclin D2-derived peptide acts on specific cell cycle phases by activating ERK1/2 to cause the death of breast cancer cells. JOURNAL OF PROTEOMICS, v. 151, n. SI, p. 24-32, . (13/07467-1, 08/58264-5, 15/03983-0)
ALMEIDA, DIEGO DANTAS; KITAJIMA, JOAO PAULO; NISHIYAMA, JR., MILTON YUTAKA; CONDOMITTI, GEORGE WILLIAN; DE OLIVEIRA, URSULA CASTRO; SETUBAL, JOAO CARLOS; JUNQUEIRA-DE-AZEVEDO, INACIO L. M.. The complete mitochondrial genome of Bothrops jararaca (Reptilia, Serpentes, Viperidae). MITOCHONDRIAL DNA PART B-RESOURCES, v. 1, p. 907-908, . (13/07467-1, 13/07974-0, 12/00177-5)
SILVA, MAKSWELL ALMEIDA; LOPES, DAIANA SILVA; TEIXEIRA, SAMUEL COTA; CIRILO GIMENES, SARAH NATALIE; VASCONCELOS AZEVEDO, FERNANDA VAN PETTEN; POLLONI, LORENA; BORGES, BRUNA CRISTINA; DA SILVA, MARCELO SANTOS; BARBOSA, MARCELO JOSE; DE OLIVEIRA JUNIOR, ROBSON JOSE; et al. Genotoxic effects of BnSP-6, a Lys-49 phospholipase A(2) (PLA(2)) homologue from Bothrops pauloensis snake venom, on MDA-MB-231 breast cancer cells. International Journal of Biological Macromolecules, v. 118, n. A, p. 311-319, . (13/07467-1, 14/24170-5)
DO NASCIMENTO, SORAIA MARIA; DE OLIVEIRA, URSULA CASTRO; NISHIYAMA-JR, MILTON YUTAKA; TASHIMA, ALEXANDRE KEIJI; DA SILVA JUNIOR, PEDRO ISMAEL. Presence of a neprilysin on Avicularia juruensis (Mygalomorphae: Theraphosidae) venom. Toxin Reviews, . (13/07467-1)
FALCAO, MARIA ALICE PIMENTEL; WALKER, CRISTIANI ISABEL BANDERO; DISNER, GEONILDO RODRIGO; BATISTA-FILHO, JOAO; SOARES, AMANDA BEATRIZ SILVA; BALAN-LIMA, LETICIA; LIMA, CARLA; LOPES-FERREIRA, MONICA. nockdown of miR-26a in zebrafish leads to impairment of the anti-inflammatory function of TnP in the control of neutrophili. FISH & SHELLFISH IMMUNOLOGY, v. 114, p. 301-310, . (13/07467-1)
CAMPOS, POLLYANNA FERNANDES; ANDRADE-SILVA, DEBORA; ZELANIS, ANDRE; PAES LEME, ADRIANA FRANCO; TEIXEIRA ROCHA, MARISA MARIA; MENEZES, MILENE CRISTINA; SERRANO, SOLANGE M. T.; MEIRELLES JUNQUEIRA-DE-AZEVE, INACIO DE LOIOLA. Trends in the Evolution of Snake Toxins Underscored by an Integrative Omics Approach to Profile the Venom of the Colubrid Phalotris mertensi. GENOME BIOLOGY AND EVOLUTION, v. 8, n. 8, p. 2266-2287, . (13/07467-1)
JUNQUEIRA-DE-AZEVEDO, INACIO L. M.; CAMPOS, POLLYANNA F.; CHING, ANA T. C.; MACKESSY, STEPHEN P.. Colubrid Venom Composition: An -Omics Perspective. TOXINS, v. 8, n. 8, . (13/07467-1, 12/00177-5)
ANDRADE-SILVA, DEBORA; ZELANIS, ANDRE; KITANO, EDUARDO S.; JUNQUEIRA-DE-AZEVEDO, INACIO L. M.; REIS, MARCELO S.; LOPES, ALINE S.; SERRANO, SOLANGE M. T.. Proteomic and Glycoproteomic Profilings Reveal That Post- translational Modifications of Toxins Contribute to Venom Phenotype in Snakes. JOURNAL OF PROTEOME RESEARCH, v. 15, n. 8, p. 2658-2675, . (13/07467-1, 13/13548-4)
GARCIA, P. R. A. F.; BICEV, R. N.; OLIVEIRA, C. L. P.; SANT'ANNA, O. A.; FANTINI, M. C. A.. Protein encapsulation in SBA-15 with expanded pores. Microporous and Mesoporous Materials, v. 235, p. 59-68, . (13/07467-1)
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