The aim of the present work was to prepare and evaluate cocrystals of a 1:1 stoichiometric molar ... more The aim of the present work was to prepare and evaluate cocrystals of a 1:1 stoichiometric molar ratio of Tadalafil (TDF). Liquid assisted grinding method was explored and the cocrystals were evaluated for their physicochemical properties, bioavailability and residual solvent study. Their preparation was confirmed and characterized by spectroscopic (FT-IR), crystallographic (XRPD) and thermoanalytical (Melting point, DSC) techniques. Solubility and dissolution studies were done in water and buffer solutions. Cocrystals showed improvements in solubility and dissolution behaviour. The cocrystals showed reduced logP values, optimium thermal stability and reduced hygroscopicity in comparison to the parent drug. Further bioavailability of these cocrystals was done in rats and pharmacokinetic parameters indicated an improved in bioavailability of cocrystals in comparison to TDF alone. GC-HS analysis was done to confirm whether the amount of residual solvent in the co-crystals is within th...
The aim of the present work was to prepare and evaluate cocrystals of a 1:1 stoichiometric molar ... more The aim of the present work was to prepare and evaluate cocrystals of a 1:1 stoichiometric molar ratio of Tadalafil (TDF). Liquid assisted grinding method was explored and the cocrystals were evaluated for their physicochemical properties, bioavailability and residual solvent study. Their preparation was confirmed and characterized by spectroscopic (FT-IR), crystallographic (XRPD) and thermoanalytical (Melting point, DSC) techniques. Solubility and dissolution studies were done in water and buffer solutions. Cocrystals showed improvements in solubility and dissolution behaviour. The cocrystals showed reduced logP values, optimium thermal stability and reduced hygroscopicity in comparison to the parent drug. Further bioavailability of these cocrystals was done in rats and pharmacokinetic parameters indicated an improved in bioavailability of cocrystals in comparison to TDF alone. GC-HS analysis was done to confirm whether the amount of residual solvent in the co-crystals is within th...
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Papers by Vijay Parmar