ABSTRACTObjectivesCurcumin has been claimed to have gastrointestinal benefits, including dyspepsi... more ABSTRACTObjectivesCurcumin has been claimed to have gastrointestinal benefits, including dyspepsia, a common disorder that could be managed in a primary care setting with behavioral and dietary modifications as well as over-the-counter medications. This study aimed to compare the efficacy of curcumin versus omeprazole in improving patient-reported outcomes.DesignPatients with functional dyspepsia were randomized to curcumin alone (C), omeprazole alone (O), or curcumin plus omeprazole (C+O). Patients in the combination group received 2 capsules of 250 mg curcumin 4 times daily and 1 capsule of 20 mg omeprazole once daily for 28 days. The primary outcomes were functional dyspepsia symptoms on days 28 and 56 assessed using the Severity of Dyspepsia Assessment (SODA) scores. Secondary outcomes were the occurrence of adverse events (AEs) and serious adverse events (SAEs).ResultsA total of 206 enrolled patients were randomly assigned to the three groups, of which 151 completed the study. ...
Objective. This present study aimed to explore the clinical effects of ultrasound-guided (USG) me... more Objective. This present study aimed to explore the clinical effects of ultrasound-guided (USG) mechanical needling with sterile water injection for lumbar facet joint syndrome. Methods. This was a retrospective cohort study that assessed the clinical outcome of ageing patients who received USG mechanical needling with sterile water injection. In addition, the clinical outcome of age- and gender-matched patients randomly selected from patients who received mechanical needling with sterile water was compared to the patients injected with steroids in a 2 : 1 ratio. The data were extracted from the medical records of ageing patients with facet joint syndrome who received USG injection at the lumbosacral spine by the first author. Low back pain or axial pain, and leg pain or radicular pain were assessed by the visual analogue scale (VAS), and gait ability with walking distance was obtained at 6 different time points. Results. A total of 4,276 medical records were examined. Four thousand ...
During the early phase of the COVID-19 pandemic, several countries, including Thailand, provided ... more During the early phase of the COVID-19 pandemic, several countries, including Thailand, provided two shots of CoronaVac to healthcare workers. Whereas ChAdOx1 nCoV-19 is the promising vaccine as the booster dose, the data on immunogenicity when administered after CoronaVac have been limited. The purpose of this study was to evaluate the immunogenicity of ChAdOx1 nCoV-19 as the third dose vaccine in healthcare workers who previously received two shots of CoronaVac. The blood samples were obtained before the third vaccination dose, and one month and three months after vaccination. All participants were measured for humoral immunity including anti-spike IgG and neutralizing antibody by ELISA. Twenty participants were stratified by random samples based on baseline IgG status for a cellular immunity function test at three-month post-vaccination, which included T cell and B cell functions by ELISpot. This study showed significant improvement for both humoral and cellular immunity one mont...
ABSTRACTBACKGROUNDCOVID-19 seroprevalence data has been scarce, especially in less developed coun... more ABSTRACTBACKGROUNDCOVID-19 seroprevalence data has been scarce, especially in less developed countries with a relatively low infection rate.METHODSA locally developed rapid immunoglobulin M (IgM) / immunoglobulin G (IgG) test kit was used for screening hospital staff in Ranong hospital which located in a province with zero COVID-19 prevalence in Thailand from April 17 to May 17, 2020. A total of 844 participants were tested; 82 of which were tested twice with one month apart. (Thai Clinical Trials Registry: TCTR20200426002)RESULTSOverall, 0.8% of the participants (7 of 844) had positive IgM, none had positive IgG. Female staff seemed to have higher IgM seropositive than male staff (1.0% vs. 0.5%). None of the participants with a history of travel to the high-risk area or a history of close contact with PCR-confirmed COVID-19 case had developed antibodies against SARS-CoV-2. Among 844 staff, 811 had no symptom and six of them developed IgM seropositive (0.7%) while 33 had minor sympt...
Prehospital Management in the Thailand Cave Rescue The dramatic rescue of a youth soccer team fro... more Prehospital Management in the Thailand Cave Rescue The dramatic rescue of a youth soccer team from Tham Luang cave in 2018 offered important lessons in the care of patients with hypothermia.
Abstract: The ongoing COVID-19 pandemic, which plunging the entire aviation industry into a deep ... more Abstract: The ongoing COVID-19 pandemic, which plunging the entire aviation industry into a deep crisis and putting hundreds of thousands of airline jobs at risk, affects Thai Airways flight attendants, with high stressors towards their job insecurity. As human factors are considered critical aspects that influence safety in aviation, this study aimed to 1) examine the impact of job insecurity on Thai Airways flight attendants' mental health during COVID-19 disruption, 2) investigate how they managed themselves to regain life satisfaction during the indefinite suspension of all scheduled flights, and 3) measure psychological distress development, a year after the airline announcement to halt all air services. The GHQ-12 (General Health Questionnaire-12), a self-administered instrument, was adopted to screen flight attendants' psychological well-being. Five male and seven female flight attendants, who had the highest scores, indicating worse conditions between 9 to 11 of total scores 12, were selected for the in-depth online interviews in February 2020 and a year later in January 2021. The result showed psychological strains caused by prolonged stress that can lead to safety-related performance decrements when flight attendants need to perform safety-critical roles in emergencies. Hence, the flight attendants should have a mental health check-up before resuming regular commercial flight operations. Keywords: COVID-19; flight attendants; job insecurity; mental health
Background Complementary and Alternative Medicine (CAM) has gained popularity among the general p... more Background Complementary and Alternative Medicine (CAM) has gained popularity among the general population, but its acceptance and use among medical specialists have been inconclusive. This systematic review aimed to identify relevant studies and synthesize survey data on the acceptance and use of CAM among medical specialists. Methods We conducted a systematic literature search in PubMed and Scopus databases for the acceptance and use of CAM among medical specialists. Each article was assessed by two screeners. Only survey studies relevant to the acceptance and use of CAM among medical specialists were reviewed. The pooled prevalence estimates were calculated using random-effects meta-analyses. This review followed both PRISMA and SWiM guidelines. Results Of 5628 articles published between 2002 and 2017, 25 fulfilled the selection criteria. Ten medical specialties were included: Internal Medicine (11 studies), Pediatrics (6 studies), Obstetrics and Gynecology (6 studies), Anesthesi...
Objective: To study the effect of ultrasound-guided (USG) needling and lidocaine plus sterile wat... more Objective: To study the effect of ultrasound-guided (USG) needling and lidocaine plus sterile water injections in lumbar spinal stenosis (LSS). Method: This retrospective study examined data of LSS patients who received USG lidocaine injection to lumbar facets, medial branches to facet joints, and multifidus muscles with one needle insertion at 4 spinal levels. Results: A total of 213 lumbar spinal stenosis patients--104 patients received USG needling and 1% lidocaine without adrenaline 2 ml plus sterile water 10 ml injection (Group A) and 109 patients received 1% lidocaine without adrenaline 6 ml injection (Group B)--for 4 times, once per week. The VAS of chronic low back pain, radicular pain, claudication, and walking ability of both groups at 3, 6, and 12 months were significantly better than the baseline. Group A reported significantly better chronic low back pain, radicular pain, claudication, and walking ability at 3, 6, and 12 months than Group B. Conclusions: USG needling an...
Background Bilateral one-stage total knee arthroplasty (BTKA) have increased because it provides ... more Background Bilateral one-stage total knee arthroplasty (BTKA) have increased because it provides a number of advantages. Recently, Accelerometer-based navigation (ABN) system which guide the cutting plane without intramedullary disturbance might result in less endothelial and microvascular damage. Therefore, we hypothesized that the ABN may reduce blood loss, reduce postoperative pain, and better restore BTKA alignment compared to conventional instruments. Methods We retrospectively compared 44 consecutive patients receiving ABN assisted BTKA (iBTKA) to 57 patients with conventional instruments (cBTKA). Identical pre- and post-operative care was utilized to all patients. The outcome measures assessed were hemoglobin (Hb), calculated blood loss (CBL), blood transfusion, VAS score for pain, morphine consumption, knee flexion angle, and length of stay (LOS). Radiographic assessment included mechanical axis (MA) and component positioning at 3–6 months of follow up. Results Both iBTKA an...
Policy characteristics facilitating primary health care in Thailand: A pilot study in transitiona... more Policy characteristics facilitating primary health care in Thailand: A pilot study in transitional country
Fat reduction and anti-inflammation are commonly claimed properties of probiotics. Lactiplantibac... more Fat reduction and anti-inflammation are commonly claimed properties of probiotics. Lactiplantibacillus plantarum and Enterococcus faecium were tested in high fat-induced obesity mice and in vitro experiments. After 16 weeks of probiotics, L. plantarum dfa1 outperforms E. faecium dfa1 on the anti-obesity property as indicated by body weight, regional fat accumulation, serum cholesterol, inflammatory cytokines (in blood and colon tissue), and gut barrier defect (FITC-dextran assay). With fecal microbiome analysis, L. plantarum dfa1 but not E. faecium dfa1 reduced fecal abundance of pathogenic Proteobacteria without an alteration in total Gram-negative bacteria when compared with non-probiotics obese mice. With palmitic acid induction, the condition media from both probiotics similarly attenuated supernatant IL-8, improved enterocyte integrity and down-regulated cholesterol absorption-associated genes in Caco-2 cell (an enterocyte cell line) and reduced supernatant cytokines (TNF-α and...
ABSTRACTObjectivesCurcumin has been claimed to have gastrointestinal benefits, including dyspepsi... more ABSTRACTObjectivesCurcumin has been claimed to have gastrointestinal benefits, including dyspepsia, a common disorder that could be managed in a primary care setting with behavioral and dietary modifications as well as over-the-counter medications. This study aimed to compare the efficacy of curcumin versus omeprazole in improving patient-reported outcomes.DesignPatients with functional dyspepsia were randomized to curcumin alone (C), omeprazole alone (O), or curcumin plus omeprazole (C+O). Patients in the combination group received 2 capsules of 250 mg curcumin 4 times daily and 1 capsule of 20 mg omeprazole once daily for 28 days. The primary outcomes were functional dyspepsia symptoms on days 28 and 56 assessed using the Severity of Dyspepsia Assessment (SODA) scores. Secondary outcomes were the occurrence of adverse events (AEs) and serious adverse events (SAEs).ResultsA total of 206 enrolled patients were randomly assigned to the three groups, of which 151 completed the study. ...
Objective. This present study aimed to explore the clinical effects of ultrasound-guided (USG) me... more Objective. This present study aimed to explore the clinical effects of ultrasound-guided (USG) mechanical needling with sterile water injection for lumbar facet joint syndrome. Methods. This was a retrospective cohort study that assessed the clinical outcome of ageing patients who received USG mechanical needling with sterile water injection. In addition, the clinical outcome of age- and gender-matched patients randomly selected from patients who received mechanical needling with sterile water was compared to the patients injected with steroids in a 2 : 1 ratio. The data were extracted from the medical records of ageing patients with facet joint syndrome who received USG injection at the lumbosacral spine by the first author. Low back pain or axial pain, and leg pain or radicular pain were assessed by the visual analogue scale (VAS), and gait ability with walking distance was obtained at 6 different time points. Results. A total of 4,276 medical records were examined. Four thousand ...
During the early phase of the COVID-19 pandemic, several countries, including Thailand, provided ... more During the early phase of the COVID-19 pandemic, several countries, including Thailand, provided two shots of CoronaVac to healthcare workers. Whereas ChAdOx1 nCoV-19 is the promising vaccine as the booster dose, the data on immunogenicity when administered after CoronaVac have been limited. The purpose of this study was to evaluate the immunogenicity of ChAdOx1 nCoV-19 as the third dose vaccine in healthcare workers who previously received two shots of CoronaVac. The blood samples were obtained before the third vaccination dose, and one month and three months after vaccination. All participants were measured for humoral immunity including anti-spike IgG and neutralizing antibody by ELISA. Twenty participants were stratified by random samples based on baseline IgG status for a cellular immunity function test at three-month post-vaccination, which included T cell and B cell functions by ELISpot. This study showed significant improvement for both humoral and cellular immunity one mont...
ABSTRACTBACKGROUNDCOVID-19 seroprevalence data has been scarce, especially in less developed coun... more ABSTRACTBACKGROUNDCOVID-19 seroprevalence data has been scarce, especially in less developed countries with a relatively low infection rate.METHODSA locally developed rapid immunoglobulin M (IgM) / immunoglobulin G (IgG) test kit was used for screening hospital staff in Ranong hospital which located in a province with zero COVID-19 prevalence in Thailand from April 17 to May 17, 2020. A total of 844 participants were tested; 82 of which were tested twice with one month apart. (Thai Clinical Trials Registry: TCTR20200426002)RESULTSOverall, 0.8% of the participants (7 of 844) had positive IgM, none had positive IgG. Female staff seemed to have higher IgM seropositive than male staff (1.0% vs. 0.5%). None of the participants with a history of travel to the high-risk area or a history of close contact with PCR-confirmed COVID-19 case had developed antibodies against SARS-CoV-2. Among 844 staff, 811 had no symptom and six of them developed IgM seropositive (0.7%) while 33 had minor sympt...
Prehospital Management in the Thailand Cave Rescue The dramatic rescue of a youth soccer team fro... more Prehospital Management in the Thailand Cave Rescue The dramatic rescue of a youth soccer team from Tham Luang cave in 2018 offered important lessons in the care of patients with hypothermia.
Abstract: The ongoing COVID-19 pandemic, which plunging the entire aviation industry into a deep ... more Abstract: The ongoing COVID-19 pandemic, which plunging the entire aviation industry into a deep crisis and putting hundreds of thousands of airline jobs at risk, affects Thai Airways flight attendants, with high stressors towards their job insecurity. As human factors are considered critical aspects that influence safety in aviation, this study aimed to 1) examine the impact of job insecurity on Thai Airways flight attendants' mental health during COVID-19 disruption, 2) investigate how they managed themselves to regain life satisfaction during the indefinite suspension of all scheduled flights, and 3) measure psychological distress development, a year after the airline announcement to halt all air services. The GHQ-12 (General Health Questionnaire-12), a self-administered instrument, was adopted to screen flight attendants' psychological well-being. Five male and seven female flight attendants, who had the highest scores, indicating worse conditions between 9 to 11 of total scores 12, were selected for the in-depth online interviews in February 2020 and a year later in January 2021. The result showed psychological strains caused by prolonged stress that can lead to safety-related performance decrements when flight attendants need to perform safety-critical roles in emergencies. Hence, the flight attendants should have a mental health check-up before resuming regular commercial flight operations. Keywords: COVID-19; flight attendants; job insecurity; mental health
Background Complementary and Alternative Medicine (CAM) has gained popularity among the general p... more Background Complementary and Alternative Medicine (CAM) has gained popularity among the general population, but its acceptance and use among medical specialists have been inconclusive. This systematic review aimed to identify relevant studies and synthesize survey data on the acceptance and use of CAM among medical specialists. Methods We conducted a systematic literature search in PubMed and Scopus databases for the acceptance and use of CAM among medical specialists. Each article was assessed by two screeners. Only survey studies relevant to the acceptance and use of CAM among medical specialists were reviewed. The pooled prevalence estimates were calculated using random-effects meta-analyses. This review followed both PRISMA and SWiM guidelines. Results Of 5628 articles published between 2002 and 2017, 25 fulfilled the selection criteria. Ten medical specialties were included: Internal Medicine (11 studies), Pediatrics (6 studies), Obstetrics and Gynecology (6 studies), Anesthesi...
Objective: To study the effect of ultrasound-guided (USG) needling and lidocaine plus sterile wat... more Objective: To study the effect of ultrasound-guided (USG) needling and lidocaine plus sterile water injections in lumbar spinal stenosis (LSS). Method: This retrospective study examined data of LSS patients who received USG lidocaine injection to lumbar facets, medial branches to facet joints, and multifidus muscles with one needle insertion at 4 spinal levels. Results: A total of 213 lumbar spinal stenosis patients--104 patients received USG needling and 1% lidocaine without adrenaline 2 ml plus sterile water 10 ml injection (Group A) and 109 patients received 1% lidocaine without adrenaline 6 ml injection (Group B)--for 4 times, once per week. The VAS of chronic low back pain, radicular pain, claudication, and walking ability of both groups at 3, 6, and 12 months were significantly better than the baseline. Group A reported significantly better chronic low back pain, radicular pain, claudication, and walking ability at 3, 6, and 12 months than Group B. Conclusions: USG needling an...
Background Bilateral one-stage total knee arthroplasty (BTKA) have increased because it provides ... more Background Bilateral one-stage total knee arthroplasty (BTKA) have increased because it provides a number of advantages. Recently, Accelerometer-based navigation (ABN) system which guide the cutting plane without intramedullary disturbance might result in less endothelial and microvascular damage. Therefore, we hypothesized that the ABN may reduce blood loss, reduce postoperative pain, and better restore BTKA alignment compared to conventional instruments. Methods We retrospectively compared 44 consecutive patients receiving ABN assisted BTKA (iBTKA) to 57 patients with conventional instruments (cBTKA). Identical pre- and post-operative care was utilized to all patients. The outcome measures assessed were hemoglobin (Hb), calculated blood loss (CBL), blood transfusion, VAS score for pain, morphine consumption, knee flexion angle, and length of stay (LOS). Radiographic assessment included mechanical axis (MA) and component positioning at 3–6 months of follow up. Results Both iBTKA an...
Policy characteristics facilitating primary health care in Thailand: A pilot study in transitiona... more Policy characteristics facilitating primary health care in Thailand: A pilot study in transitional country
Fat reduction and anti-inflammation are commonly claimed properties of probiotics. Lactiplantibac... more Fat reduction and anti-inflammation are commonly claimed properties of probiotics. Lactiplantibacillus plantarum and Enterococcus faecium were tested in high fat-induced obesity mice and in vitro experiments. After 16 weeks of probiotics, L. plantarum dfa1 outperforms E. faecium dfa1 on the anti-obesity property as indicated by body weight, regional fat accumulation, serum cholesterol, inflammatory cytokines (in blood and colon tissue), and gut barrier defect (FITC-dextran assay). With fecal microbiome analysis, L. plantarum dfa1 but not E. faecium dfa1 reduced fecal abundance of pathogenic Proteobacteria without an alteration in total Gram-negative bacteria when compared with non-probiotics obese mice. With palmitic acid induction, the condition media from both probiotics similarly attenuated supernatant IL-8, improved enterocyte integrity and down-regulated cholesterol absorption-associated genes in Caco-2 cell (an enterocyte cell line) and reduced supernatant cytokines (TNF-α and...
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