OFF-X Translational Safety Intelligence
A unique translational tool providing drug and class safety intelligence to anticipate risks and drive new competitive value
De-risk your R&D programs
Monitor and anticipate safety signals
Make confident decisions
Integrated data
Benchmark safety profiles and assess risks
Quickly understand safety liabilities of drug classes by comparing the safety profiles of your competitor’s drugs based on daily updated, manually curated data.
Predict preclinical toxicity and anticipate adverse reactions
Connect and integrate critical safety intelligence from early target discovery to post-marketing to anticipate and translate toxicity events from the lab to the clinic.
Support signal detection, prioritization, and evaluation
Reduce the time and resources required to retrieve safety intelligence needed to stay abreast of regulatory and pharmacovigilance concerns for a given drug or drug class.
Comprehensive range of safety information sources and dataset
All sourced from peer-reviewed journals, congresses, company communications, clinical trial registries, regulatory agency communications around the world and FDA, EMA, and PDMA approval packages
User-friendly visualizations
Quickly assess critical preclinical toxicity data and clinical safety data with user-friendly visualizations, including:
- Comparative table builder to anticipate the safety of novel drugs and combinations or assess the mechanisms behind unexpected toxicities
- Translational safety to anticipate and track potential liabilities as clinical trials starts and actions to mitigate risks
- Chemistry dashboard to correlate chemical structures with safety liabilities
- Real-world evidence dashboard to quickly assess new potential safety signals
Wide-ranging analytics
Support R&D, clinical and pharmacovigilance teams with comprehensive safety data and analytics, including:
- Drug score to estimate the strength of evidence supporting a given drug-adverse event association
- Target class score to identify and monitor emerging target class liabilities
- Mounting evidence charts to assess the safety evidence and trends for a given drug or target-adverse event association
- Pathway maps to assess and prioritize investigational target safety based on signaling cascades
Integrate internal data and OFF-X via APIs or data feeds
- Connect to translational safety data ecosystem through APIs or data feeds
- Integrate with in-house data sources and modeling applications
- Enrich and expand depth of internal resources to enable your teams to uncover hidden insights in data
Related news
Food and Drug Administration (FDA) and Clarivate Extend Material Transfer Agreement for Three Additional Years
Partnership enables agency-wide access to OFF-X translational safety intelligence solution London, U.K., May 23, 2023 –– Clarivate Plc (NYSE: CLVT), a global leader in connecting people and organizations to intelligence they can…
