Novel biosensors already provide a fast way to detect the adhesion of whole bacteria (or parts of... more Novel biosensors already provide a fast way to detect the adhesion of whole bacteria (or parts of them), biofilm formation, and the effect of antibiotics. Moreover, the detection sensitivities of recent sensor technologies are large enough to investigate molecular-scale biological processes. Usually, these measurements can be performed in real time without using labeling. Despite these excellent capabilities summarized in the present work, the application of novel, label-free sensor technologies in basic biological research is still rare; the literature is dominated by heuristic work, mostly monitoring the presence and amount of a given analyte. The aims of this review are (i) to give an overview of the present status of label-free biosensors in bacteria monitoring, and (ii) to summarize potential novel directions with biological relevancies to initiate future development. Optical, mechanical, and electrical sensing technologies are all discussed with their detailed capabilities in ...
One has the distinct perception that the debate on the future of science, especially regarding th... more One has the distinct perception that the debate on the future of science, especially regarding the acquisition of more knowledge, is hotting up. We appear to be in the midst of fast and furious change—in which the internet, new modes of funding, disseminating and applying science, and of educating future scientists, and the sheer volume of English-language scientific papers now emanating from China are all contributing. Whether the changes currently taking place are qualitatively greater than those associated with previous scientific revolutions is hard to say, but we certainly risk being overwhelmed by their quantitative hugeness, which seems unprecedented. Perhaps the present fervour, at least in the UK, is a symptom of a nation under stress, beset on all sides by new forms of competition, much as must have been felt by Britain on the threshold of World War I, when its more or less satisfactory arrangement of recruiting troops by the individual efforts of local grandees was sudden...
This brief chapter introduces some more -omics topics, encompassing polysaccharides, lipids and t... more This brief chapter introduces some more -omics topics, encompassing polysaccharides, lipids and the resident bacteria.
Langmuir (floating) monolayers, the precursors to Langmuir–Blodgett (LB) films, are outlined befo... more Langmuir (floating) monolayers, the precursors to Langmuir–Blodgett (LB) films, are outlined before dealing with the monolayer transfer to create the LB films themselves. The Langmuir–Schaefer (LS) transfer technique is presented as a subtype of the LB approach. A guide to the metrology of the films is given. Posttransfer modifications of LB films are covered as a useful ways to extend the range of obtainable materials and structures. Finally, applications are surveyed. Most current interest is in using LB films as research tools rather than as a means of high volume nanoscale fabrication, although the potential offered by the use of novel molecules to build up precise supramolecular structures is emphasized. Keywords: Langmuir–Blodgett; Langmuir–Schaefer; monolayers; transfer; stability; eutactic; superlattices
Novel biosensors already provide a fast way to detect the adhesion of whole bacteria (or parts of... more Novel biosensors already provide a fast way to detect the adhesion of whole bacteria (or parts of them), biofilm formation, and the effect of antibiotics. Moreover, the detection sensitivities of recent sensor technologies are large enough to investigate molecular-scale biological processes. Usually, these measurements can be performed in real time without using labeling. Despite these excellent capabilities summarized in the present work, the application of novel, label-free sensor technologies in basic biological research is still rare; the literature is dominated by heuristic work, mostly monitoring the presence and amount of a given analyte. The aims of this review are (i) to give an overview of the present status of label-free biosensors in bacteria monitoring, and (ii) to summarize potential novel directions with biological relevancies to initiate future development. Optical, mechanical, and electrical sensing technologies are all discussed with their detailed capabilities in ...
One has the distinct perception that the debate on the future of science, especially regarding th... more One has the distinct perception that the debate on the future of science, especially regarding the acquisition of more knowledge, is hotting up. We appear to be in the midst of fast and furious change—in which the internet, new modes of funding, disseminating and applying science, and of educating future scientists, and the sheer volume of English-language scientific papers now emanating from China are all contributing. Whether the changes currently taking place are qualitatively greater than those associated with previous scientific revolutions is hard to say, but we certainly risk being overwhelmed by their quantitative hugeness, which seems unprecedented. Perhaps the present fervour, at least in the UK, is a symptom of a nation under stress, beset on all sides by new forms of competition, much as must have been felt by Britain on the threshold of World War I, when its more or less satisfactory arrangement of recruiting troops by the individual efforts of local grandees was sudden...
This brief chapter introduces some more -omics topics, encompassing polysaccharides, lipids and t... more This brief chapter introduces some more -omics topics, encompassing polysaccharides, lipids and the resident bacteria.
Langmuir (floating) monolayers, the precursors to Langmuir–Blodgett (LB) films, are outlined befo... more Langmuir (floating) monolayers, the precursors to Langmuir–Blodgett (LB) films, are outlined before dealing with the monolayer transfer to create the LB films themselves. The Langmuir–Schaefer (LS) transfer technique is presented as a subtype of the LB approach. A guide to the metrology of the films is given. Posttransfer modifications of LB films are covered as a useful ways to extend the range of obtainable materials and structures. Finally, applications are surveyed. Most current interest is in using LB films as research tools rather than as a means of high volume nanoscale fabrication, although the potential offered by the use of novel molecules to build up precise supramolecular structures is emphasized. Keywords: Langmuir–Blodgett; Langmuir–Schaefer; monolayers; transfer; stability; eutactic; superlattices
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Papers by Jeremy Ramsden