1. The effect of certain pesticides on the functional integrity of the developing blood-brain bar... more 1. The effect of certain pesticides on the functional integrity of the developing blood-brain barrier (BBB) was studied following single and repeated exposure, and after subsequent withdrawal in rats. 2. Ten-day-old rat pups exposed orally to quinalphos (QP, organophosphate), cypermethrin (CM, pyrethroid) and lindane (LD, organochlorine) at a dose of 1/50th of LD50, showed a significant increase in the brain uptake index (BUI) for a micromolecular tracer, sodium fluorescein (SF), by 97, 37 and 72%, respectively, after 2 h. Residual increases in the BUI were found even after 3 days of the single treatment of QP (28%) and LD (23%). 3. Repeated exposure for 8 days (postnatal days (PND) 10-17) with QP, CM and LD increased the BBB permeability by 130, 80 and 50%, respectively. Recovery from these changes was complete in QP and LD-treated animals after 13 days (PND 18-30) of withdrawal. However, CM showed persistent effects that were normalized only after 43 days (PND 18-60) of withdrawal. 4. A single dose reduced to 1/100th of LD50 also increased BUI in 10-day-old rat pups following QP (20%) and CM (28%) exposure at 2 h. 5. An age-dependent effect of these pesticides was evident from the study showing higher magnitude of BUI changes in 10-day-old rats as compared to that in 15-day-old rats. Furthermore, adult rats did not show any effect on BBB permeability even at a higher dose (1/25th of LD50) of these pesticides given alone or in combination with piperonyl butoxide (600 mg/kg, i.p.) for 3 consecutive days. 6. This study showed that developing BBB is highly vulnerable to single or repeated exposure of certain pesticides. The observed persistent effects during brain development even after withdrawal of the treatment may produce some neurological dysfunction at later life as well.
We observed a plume of air highly enriched in carbon monoxide and particles in the stratosphere a... more We observed a plume of air highly enriched in carbon monoxide and particles in the stratosphere at altitudes up to 15.8 km. It can be unambiguously attributed to North American forest fires. This plume demonstrates an extra-tropical direct transport path from the planetary boundary layer several kilometers deep into the stratosphere, which is not fully captured by large-scale atmospheric transport
Title: Polarized orbital calculations of positron collisions with lithium atoms. Authors: Tien Da... more Title: Polarized orbital calculations of positron collisions with lithium atoms. Authors: Tien Dai,Bui; Stauffer, AD. Publication: Canadian Journal of Physics. Vol. 49, p.2527. Publication Date: 00/1971. Origin: ADS. Bibliographic Code: 1971CaJPh..49.2527T. Abstract. Not Available
Adequate homeostasis of cellular energetics is important for proper cell functioning. Phenomena l... more Adequate homeostasis of cellular energetics is important for proper cell functioning. Phenomena like adaptation to environmental changes, differentiation of cells, stress tolerance and the architectural dynamics of cells are all critically dependent on the localised availability of ATP, the main carrier of chemical energy. Mitochondria as the major supplier for ATP are, therefore, central to the control of these processes. During energy stress, cells may remodel their mitochondrial network in accordance to the metabolic needs. In parallel, changes in the cell energy state also may result in dynamic adaptations of the acto-myosin cytoskeleton. Since cell surface characteristics like filopodia, lamellipodia, ruffles and phagosomes are largely determined by the actomyosin cytoskeleton, we hypothesize that the cellular energy state can be reflected by the surface morphology of the cell.
The ionization rates of electrons and holes in Ge have been measured from 200 to 300°K and were f... more The ionization rates of electrons and holes in Ge have been measured from 200 to 300°K and were fit to the Baraff theory, in which the optical-phonon mean free path is verified to be temperature dependent and fits to the formula λ=λ0 tanh(Ep∕2KT), where Ep is the average optical-phonon energy. The asymptotic optical-phonon mean free paths deduced from experiments are
Abstract: Precise sample stage positioning plays an important role for various FIB (Focused Ion B... more Abstract: Precise sample stage positioning plays an important role for various FIB (Focused Ion Beam) and SEM (scanning electron microscope) applications in micro-and nanotechnology. During the last few years, FIB instruments have become an ...
AimsTo evaluate the effects of gender, food and grapefruit juice on the pharmacokinetics of prima... more AimsTo evaluate the effects of gender, food and grapefruit juice on the pharmacokinetics of primaquine in healthy subjects.To evaluate the effects of gender, food and grapefruit juice on the pharmacokinetics of primaquine in healthy subjects.MethodsIn a randomized, two-phase cross-over study, 10 male and 10 female healthy Vietnamese subjects were administered 30 mg primaquine in the fasting state or with food, followed by administration of primaquine with grapefruit juice.In a randomized, two-phase cross-over study, 10 male and 10 female healthy Vietnamese subjects were administered 30 mg primaquine in the fasting state or with food, followed by administration of primaquine with grapefruit juice.ResultsThe pharmacokinetics of primaquine were comparable between male and female subjects, with geometric mean ratios of Cmax = 0.89 [95% confidence interval (CI) 0.65, 1.22] and AUC = 0.80 (95% CI 0.56, 1.15). The mean CL/F of primaquine was slightly higher in males than in females [0.52 l h−1 kg−1vs. 0.43 l h−1 kg−1, mean difference of 0.09 (95% CI –0.10, 0.28), P = 0.32]. When compared with fasting state values, food increased the geometric mean Cmax of primaquine by 26% (95% CI 12, 40) and the AUC by 14% (95% CI 3, 27). Similarly, grapefruit juice increased the geometric mean Cmax by 23% (95% CI 4, 45) and the AUC by 19% (95% CI 4, 37).The pharmacokinetics of primaquine were comparable between male and female subjects, with geometric mean ratios of Cmax = 0.89 [95% confidence interval (CI) 0.65, 1.22] and AUC = 0.80 (95% CI 0.56, 1.15). The mean CL/F of primaquine was slightly higher in males than in females [0.52 l h−1 kg−1vs. 0.43 l h−1 kg−1, mean difference of 0.09 (95% CI –0.10, 0.28), P = 0.32]. When compared with fasting state values, food increased the geometric mean Cmax of primaquine by 26% (95% CI 12, 40) and the AUC by 14% (95% CI 3, 27). Similarly, grapefruit juice increased the geometric mean Cmax by 23% (95% CI 4, 45) and the AUC by 19% (95% CI 4, 37).ConclusionsThe disposition of primaquine was comparable between genders, suggesting no need to modify the dose of primaquine for malaria treatment or prophylaxis. Food increased the oral bioavailability of primaquine, which may lead to higher antimalarial efficacy. Grapefruit juice increased the bioavailability of primaquine, with marked interindividual differences suggesting that people should not take primaquine with grapefruit juice.The disposition of primaquine was comparable between genders, suggesting no need to modify the dose of primaquine for malaria treatment or prophylaxis. Food increased the oral bioavailability of primaquine, which may lead to higher antimalarial efficacy. Grapefruit juice increased the bioavailability of primaquine, with marked interindividual differences suggesting that people should not take primaquine with grapefruit juice.
Objective Artesunate–amodiaquine (AAQ) is efficacious for the treatment of uncomplicated Plasmod... more Objective Artesunate–amodiaquine (AAQ) is efficacious for the treatment of uncomplicated Plasmodium falciparum malaria in Africa, but little is known about its efficacy in Southeast Asia. We compared the efficacy of dihydroartemisinin–piperaquine (DHP) and AAQ against falciparum malaria in central Vietnam.Methods Open, randomized clinical trial of 116 patients (36 children aged 6–14 years, 80 adults aged 15–60 years) were randomly allocated a 3-day course of either DHP (∼2.3 mg/kg dihydroartemisinin plus ∼18.5 mg/kg of piperaquine per day) or AAQ (∼4.4 mg/kg of artesunate plus ∼10.6 mg/kg of amodiaquine per day). The follow-up period was 42 days.Results The two drug combinations were well tolerated by all age groups with no obvious drug associated adverse events. Of the patients who completed 42 days of follow-up, 49 were on DHP (15 children, 34 adults) and 49 were on AAQ (14 children, 35 adults). The 42 day cure rates adjusted for reinfection identified by PCR genotyping for the two groups were similar [100% (49/49) and 98% (48/49) for DHP and AAQ, respectively]. With fewer reinfections, DHP appears to possess greater post-treatment prophylactic activity than AAQ.Conclusion AAQ, an inexpensive artemisinin-based combination, could be an additional option to DHP for the treatment of multidrug-resistant falciparum malaria in Vietnam.Objectif: L’artésunate - amodiaquine (AAQ) est efficace pour le traitement de la malaria non compliquéàPlasmodium falciparum en Afrique, mais on en sait peu sur son efficacité en Asie du sud-est. Nous avons comparé l’efficacité de la dihydroartémisinine (DHP) et celle de l’AAQ contre la malaria falciparum dans le centre du Vietnam.Méthodes: Essai clinique randomisé ouvert sur 116 patients (36 enfants de 6 à 14 ans et 80 adultes âgés de 15 à 60 ans) aléatoirement soumis à 3 jours de traitement avec soit DHP (∼ 2,3 mg/kg dihydroartémisinine plus ∼ 18,5 mg/kg de pipéraquine par jour), soit AAQ (∼ 4,4 mg/kg d’artésunate plus ∼ 10,6 mg/kg d’amodiaquine par jour). La période de suivi était de 42 jours.Résultats: Les deux combinaisons de médicaments étaient bien tolérées par tous les groupes d’âge sans événements indésirables évidents associés aux médicaments. Parmi les patients qui ont complété 42 jours de suivi, 49 étaient sous DHP (15 enfants, 34 adultes) et 49 sous AAQ (14 enfants, 35 adultes). Les taux de guérison à 42 jours, ajustés par les réinfections identifiés par génotypage PCR, étaient similaires pour les deux groupes [100% (49/49) et 98% (48/49) pour le DHP et AAQ, respectivement]. La DHP, avec moins de réinfections, semble posséder une activité prophylactique post-traitement plus élevée que l’AAQ.Conclusion: L’AAQ, combinaison à base d’artémisinine peu coûteuse, pourrait être une option supplémentaire à la DHP pour le traitement de la malaria falciparum multirésistante au Vietnam.Objectif: L’artésunate - amodiaquine (AAQ) est efficace pour le traitement de la malaria non compliquéàPlasmodium falciparum en Afrique, mais on en sait peu sur son efficacité en Asie du sud-est. Nous avons comparé l’efficacité de la dihydroartémisinine (DHP) et celle de l’AAQ contre la malaria falciparum dans le centre du Vietnam.Méthodes: Essai clinique randomisé ouvert sur 116 patients (36 enfants de 6 à 14 ans et 80 adultes âgés de 15 à 60 ans) aléatoirement soumis à 3 jours de traitement avec soit DHP (∼ 2,3 mg/kg dihydroartémisinine plus ∼ 18,5 mg/kg de pipéraquine par jour), soit AAQ (∼ 4,4 mg/kg d’artésunate plus ∼ 10,6 mg/kg d’amodiaquine par jour). La période de suivi était de 42 jours.Résultats: Les deux combinaisons de médicaments étaient bien tolérées par tous les groupes d’âge sans événements indésirables évidents associés aux médicaments. Parmi les patients qui ont complété 42 jours de suivi, 49 étaient sous DHP (15 enfants, 34 adultes) et 49 sous AAQ (14 enfants, 35 adultes). Les taux de guérison à 42 jours, ajustés par les réinfections identifiés par génotypage PCR, étaient similaires pour les deux groupes [100% (49/49) et 98% (48/49) pour le DHP et AAQ, respectivement]. La DHP, avec moins de réinfections, semble posséder une activité prophylactique post-traitement plus élevée que l’AAQ.Conclusion: L’AAQ, combinaison à base d’artémisinine peu coûteuse, pourrait être une option supplémentaire à la DHP pour le traitement de la malaria falciparum multirésistante au Vietnam.Objetivo: El artesunato - amodiaquina (AAQ) es un tratamiento eficaz de la malaria no complicada por Plasmodium falciparum en África, pero se conoce poco acerca de su eficacia en el sudeste asiático. Hemos comparado la eficacia de la dihidroartemisinina-piperaquina (DHP) y la AAQ frente a la malaria por falciparum en Vietnam central.Métodos: Ensayo clínico abierto y aleatorizado con 116 pacientes (36 niños con edades entre los 6-14 años, 80 adultos con edades entre los 15-60 años) que fueron asignados a un tratamiento de 3-días con DHP (∼2.3 mg/kg dihidroartemisinina más ∼18.5 mg/kg of piperaquina por día) o AAQ (∼4.4 mg/kg de artesunato más ∼10.6 mg/kg de amodiaquina por día). El periodo de seguimiento fue de 42 días.Resultados: Las dos combinaciones de medicamentos fueron bien toleradas por todos los grupos de edad, sin ningún efecto adverso obvio asociado. De los pacientes que terminaron el seguimiento de 42 días, 49 habían sido tratados con DHP (15 niños, 34 adultos) y 49 con AAQ (14 niños, 35 adultos). La tasa de curación a día 42, ajustada para reinfección identificada mediante el genotipaje por PCR, fue similar en los dos grupos [100% (49/49) y 98% (48/49) para DHP y AAQ, respectivamente]. Con un menor número de reinfecciones, la DHP parece poseer una mayor actividad profiláctica post-tratamiento que la AAQ.Conclusión: La AAQ, un tratamiento barato de combinación basado en la artemisinina, podría ser una opción adicional al DHP para el tratamiento de la malaria multirresistente por falciparum en Vietnam.Objetivo: El artesunato - amodiaquina (AAQ) es un tratamiento eficaz de la malaria no complicada por Plasmodium falciparum en África, pero se conoce poco acerca de su eficacia en el sudeste asiático. Hemos comparado la eficacia de la dihidroartemisinina-piperaquina (DHP) y la AAQ frente a la malaria por falciparum en Vietnam central.Métodos: Ensayo clínico abierto y aleatorizado con 116 pacientes (36 niños con edades entre los 6-14 años, 80 adultos con edades entre los 15-60 años) que fueron asignados a un tratamiento de 3-días con DHP (∼2.3 mg/kg dihidroartemisinina más ∼18.5 mg/kg of piperaquina por día) o AAQ (∼4.4 mg/kg de artesunato más ∼10.6 mg/kg de amodiaquina por día). El periodo de seguimiento fue de 42 días.Resultados: Las dos combinaciones de medicamentos fueron bien toleradas por todos los grupos de edad, sin ningún efecto adverso obvio asociado. De los pacientes que terminaron el seguimiento de 42 días, 49 habían sido tratados con DHP (15 niños, 34 adultos) y 49 con AAQ (14 niños, 35 adultos). La tasa de curación a día 42, ajustada para reinfección identificada mediante el genotipaje por PCR, fue similar en los dos grupos [100% (49/49) y 98% (48/49) para DHP y AAQ, respectivamente]. Con un menor número de reinfecciones, la DHP parece poseer una mayor actividad profiláctica post-tratamiento que la AAQ.Conclusión: La AAQ, un tratamiento barato de combinación basado en la artemisinina, podría ser una opción adicional al DHP para el tratamiento de la malaria multirresistente por falciparum en Vietnam.
1. The effect of certain pesticides on the functional integrity of the developing blood-brain bar... more 1. The effect of certain pesticides on the functional integrity of the developing blood-brain barrier (BBB) was studied following single and repeated exposure, and after subsequent withdrawal in rats. 2. Ten-day-old rat pups exposed orally to quinalphos (QP, organophosphate), cypermethrin (CM, pyrethroid) and lindane (LD, organochlorine) at a dose of 1/50th of LD50, showed a significant increase in the brain uptake index (BUI) for a micromolecular tracer, sodium fluorescein (SF), by 97, 37 and 72%, respectively, after 2 h. Residual increases in the BUI were found even after 3 days of the single treatment of QP (28%) and LD (23%). 3. Repeated exposure for 8 days (postnatal days (PND) 10-17) with QP, CM and LD increased the BBB permeability by 130, 80 and 50%, respectively. Recovery from these changes was complete in QP and LD-treated animals after 13 days (PND 18-30) of withdrawal. However, CM showed persistent effects that were normalized only after 43 days (PND 18-60) of withdrawal. 4. A single dose reduced to 1/100th of LD50 also increased BUI in 10-day-old rat pups following QP (20%) and CM (28%) exposure at 2 h. 5. An age-dependent effect of these pesticides was evident from the study showing higher magnitude of BUI changes in 10-day-old rats as compared to that in 15-day-old rats. Furthermore, adult rats did not show any effect on BBB permeability even at a higher dose (1/25th of LD50) of these pesticides given alone or in combination with piperonyl butoxide (600 mg/kg, i.p.) for 3 consecutive days. 6. This study showed that developing BBB is highly vulnerable to single or repeated exposure of certain pesticides. The observed persistent effects during brain development even after withdrawal of the treatment may produce some neurological dysfunction at later life as well.
We observed a plume of air highly enriched in carbon monoxide and particles in the stratosphere a... more We observed a plume of air highly enriched in carbon monoxide and particles in the stratosphere at altitudes up to 15.8 km. It can be unambiguously attributed to North American forest fires. This plume demonstrates an extra-tropical direct transport path from the planetary boundary layer several kilometers deep into the stratosphere, which is not fully captured by large-scale atmospheric transport
Title: Polarized orbital calculations of positron collisions with lithium atoms. Authors: Tien Da... more Title: Polarized orbital calculations of positron collisions with lithium atoms. Authors: Tien Dai,Bui; Stauffer, AD. Publication: Canadian Journal of Physics. Vol. 49, p.2527. Publication Date: 00/1971. Origin: ADS. Bibliographic Code: 1971CaJPh..49.2527T. Abstract. Not Available
Adequate homeostasis of cellular energetics is important for proper cell functioning. Phenomena l... more Adequate homeostasis of cellular energetics is important for proper cell functioning. Phenomena like adaptation to environmental changes, differentiation of cells, stress tolerance and the architectural dynamics of cells are all critically dependent on the localised availability of ATP, the main carrier of chemical energy. Mitochondria as the major supplier for ATP are, therefore, central to the control of these processes. During energy stress, cells may remodel their mitochondrial network in accordance to the metabolic needs. In parallel, changes in the cell energy state also may result in dynamic adaptations of the acto-myosin cytoskeleton. Since cell surface characteristics like filopodia, lamellipodia, ruffles and phagosomes are largely determined by the actomyosin cytoskeleton, we hypothesize that the cellular energy state can be reflected by the surface morphology of the cell.
The ionization rates of electrons and holes in Ge have been measured from 200 to 300°K and were f... more The ionization rates of electrons and holes in Ge have been measured from 200 to 300°K and were fit to the Baraff theory, in which the optical-phonon mean free path is verified to be temperature dependent and fits to the formula λ=λ0 tanh(Ep∕2KT), where Ep is the average optical-phonon energy. The asymptotic optical-phonon mean free paths deduced from experiments are
Abstract: Precise sample stage positioning plays an important role for various FIB (Focused Ion B... more Abstract: Precise sample stage positioning plays an important role for various FIB (Focused Ion Beam) and SEM (scanning electron microscope) applications in micro-and nanotechnology. During the last few years, FIB instruments have become an ...
AimsTo evaluate the effects of gender, food and grapefruit juice on the pharmacokinetics of prima... more AimsTo evaluate the effects of gender, food and grapefruit juice on the pharmacokinetics of primaquine in healthy subjects.To evaluate the effects of gender, food and grapefruit juice on the pharmacokinetics of primaquine in healthy subjects.MethodsIn a randomized, two-phase cross-over study, 10 male and 10 female healthy Vietnamese subjects were administered 30 mg primaquine in the fasting state or with food, followed by administration of primaquine with grapefruit juice.In a randomized, two-phase cross-over study, 10 male and 10 female healthy Vietnamese subjects were administered 30 mg primaquine in the fasting state or with food, followed by administration of primaquine with grapefruit juice.ResultsThe pharmacokinetics of primaquine were comparable between male and female subjects, with geometric mean ratios of Cmax = 0.89 [95% confidence interval (CI) 0.65, 1.22] and AUC = 0.80 (95% CI 0.56, 1.15). The mean CL/F of primaquine was slightly higher in males than in females [0.52 l h−1 kg−1vs. 0.43 l h−1 kg−1, mean difference of 0.09 (95% CI –0.10, 0.28), P = 0.32]. When compared with fasting state values, food increased the geometric mean Cmax of primaquine by 26% (95% CI 12, 40) and the AUC by 14% (95% CI 3, 27). Similarly, grapefruit juice increased the geometric mean Cmax by 23% (95% CI 4, 45) and the AUC by 19% (95% CI 4, 37).The pharmacokinetics of primaquine were comparable between male and female subjects, with geometric mean ratios of Cmax = 0.89 [95% confidence interval (CI) 0.65, 1.22] and AUC = 0.80 (95% CI 0.56, 1.15). The mean CL/F of primaquine was slightly higher in males than in females [0.52 l h−1 kg−1vs. 0.43 l h−1 kg−1, mean difference of 0.09 (95% CI –0.10, 0.28), P = 0.32]. When compared with fasting state values, food increased the geometric mean Cmax of primaquine by 26% (95% CI 12, 40) and the AUC by 14% (95% CI 3, 27). Similarly, grapefruit juice increased the geometric mean Cmax by 23% (95% CI 4, 45) and the AUC by 19% (95% CI 4, 37).ConclusionsThe disposition of primaquine was comparable between genders, suggesting no need to modify the dose of primaquine for malaria treatment or prophylaxis. Food increased the oral bioavailability of primaquine, which may lead to higher antimalarial efficacy. Grapefruit juice increased the bioavailability of primaquine, with marked interindividual differences suggesting that people should not take primaquine with grapefruit juice.The disposition of primaquine was comparable between genders, suggesting no need to modify the dose of primaquine for malaria treatment or prophylaxis. Food increased the oral bioavailability of primaquine, which may lead to higher antimalarial efficacy. Grapefruit juice increased the bioavailability of primaquine, with marked interindividual differences suggesting that people should not take primaquine with grapefruit juice.
Objective Artesunate–amodiaquine (AAQ) is efficacious for the treatment of uncomplicated Plasmod... more Objective Artesunate–amodiaquine (AAQ) is efficacious for the treatment of uncomplicated Plasmodium falciparum malaria in Africa, but little is known about its efficacy in Southeast Asia. We compared the efficacy of dihydroartemisinin–piperaquine (DHP) and AAQ against falciparum malaria in central Vietnam.Methods Open, randomized clinical trial of 116 patients (36 children aged 6–14 years, 80 adults aged 15–60 years) were randomly allocated a 3-day course of either DHP (∼2.3 mg/kg dihydroartemisinin plus ∼18.5 mg/kg of piperaquine per day) or AAQ (∼4.4 mg/kg of artesunate plus ∼10.6 mg/kg of amodiaquine per day). The follow-up period was 42 days.Results The two drug combinations were well tolerated by all age groups with no obvious drug associated adverse events. Of the patients who completed 42 days of follow-up, 49 were on DHP (15 children, 34 adults) and 49 were on AAQ (14 children, 35 adults). The 42 day cure rates adjusted for reinfection identified by PCR genotyping for the two groups were similar [100% (49/49) and 98% (48/49) for DHP and AAQ, respectively]. With fewer reinfections, DHP appears to possess greater post-treatment prophylactic activity than AAQ.Conclusion AAQ, an inexpensive artemisinin-based combination, could be an additional option to DHP for the treatment of multidrug-resistant falciparum malaria in Vietnam.Objectif: L’artésunate - amodiaquine (AAQ) est efficace pour le traitement de la malaria non compliquéàPlasmodium falciparum en Afrique, mais on en sait peu sur son efficacité en Asie du sud-est. Nous avons comparé l’efficacité de la dihydroartémisinine (DHP) et celle de l’AAQ contre la malaria falciparum dans le centre du Vietnam.Méthodes: Essai clinique randomisé ouvert sur 116 patients (36 enfants de 6 à 14 ans et 80 adultes âgés de 15 à 60 ans) aléatoirement soumis à 3 jours de traitement avec soit DHP (∼ 2,3 mg/kg dihydroartémisinine plus ∼ 18,5 mg/kg de pipéraquine par jour), soit AAQ (∼ 4,4 mg/kg d’artésunate plus ∼ 10,6 mg/kg d’amodiaquine par jour). La période de suivi était de 42 jours.Résultats: Les deux combinaisons de médicaments étaient bien tolérées par tous les groupes d’âge sans événements indésirables évidents associés aux médicaments. Parmi les patients qui ont complété 42 jours de suivi, 49 étaient sous DHP (15 enfants, 34 adultes) et 49 sous AAQ (14 enfants, 35 adultes). Les taux de guérison à 42 jours, ajustés par les réinfections identifiés par génotypage PCR, étaient similaires pour les deux groupes [100% (49/49) et 98% (48/49) pour le DHP et AAQ, respectivement]. La DHP, avec moins de réinfections, semble posséder une activité prophylactique post-traitement plus élevée que l’AAQ.Conclusion: L’AAQ, combinaison à base d’artémisinine peu coûteuse, pourrait être une option supplémentaire à la DHP pour le traitement de la malaria falciparum multirésistante au Vietnam.Objectif: L’artésunate - amodiaquine (AAQ) est efficace pour le traitement de la malaria non compliquéàPlasmodium falciparum en Afrique, mais on en sait peu sur son efficacité en Asie du sud-est. Nous avons comparé l’efficacité de la dihydroartémisinine (DHP) et celle de l’AAQ contre la malaria falciparum dans le centre du Vietnam.Méthodes: Essai clinique randomisé ouvert sur 116 patients (36 enfants de 6 à 14 ans et 80 adultes âgés de 15 à 60 ans) aléatoirement soumis à 3 jours de traitement avec soit DHP (∼ 2,3 mg/kg dihydroartémisinine plus ∼ 18,5 mg/kg de pipéraquine par jour), soit AAQ (∼ 4,4 mg/kg d’artésunate plus ∼ 10,6 mg/kg d’amodiaquine par jour). La période de suivi était de 42 jours.Résultats: Les deux combinaisons de médicaments étaient bien tolérées par tous les groupes d’âge sans événements indésirables évidents associés aux médicaments. Parmi les patients qui ont complété 42 jours de suivi, 49 étaient sous DHP (15 enfants, 34 adultes) et 49 sous AAQ (14 enfants, 35 adultes). Les taux de guérison à 42 jours, ajustés par les réinfections identifiés par génotypage PCR, étaient similaires pour les deux groupes [100% (49/49) et 98% (48/49) pour le DHP et AAQ, respectivement]. La DHP, avec moins de réinfections, semble posséder une activité prophylactique post-traitement plus élevée que l’AAQ.Conclusion: L’AAQ, combinaison à base d’artémisinine peu coûteuse, pourrait être une option supplémentaire à la DHP pour le traitement de la malaria falciparum multirésistante au Vietnam.Objetivo: El artesunato - amodiaquina (AAQ) es un tratamiento eficaz de la malaria no complicada por Plasmodium falciparum en África, pero se conoce poco acerca de su eficacia en el sudeste asiático. Hemos comparado la eficacia de la dihidroartemisinina-piperaquina (DHP) y la AAQ frente a la malaria por falciparum en Vietnam central.Métodos: Ensayo clínico abierto y aleatorizado con 116 pacientes (36 niños con edades entre los 6-14 años, 80 adultos con edades entre los 15-60 años) que fueron asignados a un tratamiento de 3-días con DHP (∼2.3 mg/kg dihidroartemisinina más ∼18.5 mg/kg of piperaquina por día) o AAQ (∼4.4 mg/kg de artesunato más ∼10.6 mg/kg de amodiaquina por día). El periodo de seguimiento fue de 42 días.Resultados: Las dos combinaciones de medicamentos fueron bien toleradas por todos los grupos de edad, sin ningún efecto adverso obvio asociado. De los pacientes que terminaron el seguimiento de 42 días, 49 habían sido tratados con DHP (15 niños, 34 adultos) y 49 con AAQ (14 niños, 35 adultos). La tasa de curación a día 42, ajustada para reinfección identificada mediante el genotipaje por PCR, fue similar en los dos grupos [100% (49/49) y 98% (48/49) para DHP y AAQ, respectivamente]. Con un menor número de reinfecciones, la DHP parece poseer una mayor actividad profiláctica post-tratamiento que la AAQ.Conclusión: La AAQ, un tratamiento barato de combinación basado en la artemisinina, podría ser una opción adicional al DHP para el tratamiento de la malaria multirresistente por falciparum en Vietnam.Objetivo: El artesunato - amodiaquina (AAQ) es un tratamiento eficaz de la malaria no complicada por Plasmodium falciparum en África, pero se conoce poco acerca de su eficacia en el sudeste asiático. Hemos comparado la eficacia de la dihidroartemisinina-piperaquina (DHP) y la AAQ frente a la malaria por falciparum en Vietnam central.Métodos: Ensayo clínico abierto y aleatorizado con 116 pacientes (36 niños con edades entre los 6-14 años, 80 adultos con edades entre los 15-60 años) que fueron asignados a un tratamiento de 3-días con DHP (∼2.3 mg/kg dihidroartemisinina más ∼18.5 mg/kg of piperaquina por día) o AAQ (∼4.4 mg/kg de artesunato más ∼10.6 mg/kg de amodiaquina por día). El periodo de seguimiento fue de 42 días.Resultados: Las dos combinaciones de medicamentos fueron bien toleradas por todos los grupos de edad, sin ningún efecto adverso obvio asociado. De los pacientes que terminaron el seguimiento de 42 días, 49 habían sido tratados con DHP (15 niños, 34 adultos) y 49 con AAQ (14 niños, 35 adultos). La tasa de curación a día 42, ajustada para reinfección identificada mediante el genotipaje por PCR, fue similar en los dos grupos [100% (49/49) y 98% (48/49) para DHP y AAQ, respectivamente]. Con un menor número de reinfecciones, la DHP parece poseer una mayor actividad profiláctica post-tratamiento que la AAQ.Conclusión: La AAQ, un tratamiento barato de combinación basado en la artemisinina, podría ser una opción adicional al DHP para el tratamiento de la malaria multirresistente por falciparum en Vietnam.
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