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Authors: Feng, Yi | Qin, Dui | Zhang, Jun | Ma, Chenxiang | Wan, Mingxi

Article Type: Research Article

Abstract: Cavitation has great application potential in microvessel damage and targeted drug delivery. Concerning cavitation, droplet vaporization has been widely investigated in vitro and in vivo with plasmonic nanoparticles. Droplets with a liquid dodecafluoropentane (DDFP) core enclosed in an albumin shell have a stable and simple structure with good characteristics of laser absorbing; thus, DDFP droplets could be an effective aim for laser-induced cavitation. The DDPF droplet was prepared and perfused in a mimic microvessel in the optical microscopic system with a passive acoustic detection module. Three patterns of laser-induced cavitation in the droplets were observed. The emitted acoustic signals showed …specific spectrum components at specific time points. It was suggested that a nanosecond laser pulse could induce cavitation in DDPF droplets, and specific acoustic signals would be emitted. Analyzing its characteristics could aid in monitoring the laser-induced cavitation process in droplets, which is meaningful to theranostic application. Show more

Keywords: DDFP droplet, laser induced cavitation, acoustic signal, spectrum analysis, time-frequency analysis

DOI: 10.3233/BME-151331

Citation: Bio-Medical Materials and Engineering, vol. 26, no. s1, pp. S423-S427, 2015