invivoPKfit: Fits Toxicokinetic Models to In Vivo PK Data Sets

Takes in vivo toxicokinetic concentration-time data and fits parameters of 1-compartment and 2-compartment models for each chemical. These methods are described in detail in "Informatics for Toxicokinetics" (submitted).

Version:	2.0.0
Depends:	R (≥ 3.5.0)
Imports:	cli, devtools, dplyr, ggplot2, glue, httk, magrittr, MASS, Matrix, multidplyr (≥ 0.1.3), numDeriv, optimx, PK, pracma, purrr, rlang, scales, tibble, tidyr, tidyselect
Suggests:	cowplot, knitr, RColorBrewer, rmarkdown, stringr, testthat (≥ 3.0.0), tidyverse
Published:	2025-01-09
DOI:	10.32614/CRAN.package.invivoPKfit
Author:	John Wambaugh [aut, cre], Caroline Ring [aut], Gilberto Padilla Mercado [aut], Chris Cook [aut]
Maintainer:	John Wambaugh <wambaugh.john at epa.gov>
License:	GPL-3
NeedsCompilation:	no
Materials:	NEWS
CRAN checks:	invivoPKfit results

Documentation:

Reference manual:	invivoPKfit.pdf
Vignettes:	invivoPKfit User Guide (source, R code) Wambaugh et al. (2018): Estimating TK Parameters from In Vivo Data (source, R code) manuscript2023 (source, R code) Informatics for toxicokinetics (source, R code)

Downloads:

Package source:	invivoPKfit_2.0.0.tar.gz
Windows binaries:	r-devel: not available, r-release: not available, r-oldrel: not available
macOS binaries:	r-release (arm64): invivoPKfit_2.0.0.tgz, r-oldrel (arm64): invivoPKfit_2.0.0.tgz, r-release (x86_64): invivoPKfit_2.0.0.tgz, r-oldrel (x86_64): invivoPKfit_2.0.0.tgz

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