The effect of exercise upon the uptake of radioiodine by the thyroid was examined in both rats an... more The effect of exercise upon the uptake of radioiodine by the thyroid was examined in both rats and humans. Rats that exercised intermittently on a mechanical wheel for a period of 20 days had significantly lower uptake values (p < 0.0001) than sedentary controls. Human volunteers that ran at least ten miles/week had a lower mean 24-hr uptake value (8.0 +/- 2.8%) than nonexercising subjects (14.3 +/- 5.1%, p < 0.01). Other thyroid function studies (thyroxine, triiodothyronine, triiodothyronine resin uptake, thyroid-stimulating hormone) did not differ significantly between the exercising and nonexercising groups. These studies suggest that exercise significantly alters thyroid iodine economy.
Bravos for Cohen and Insel! 1 They correctly identify major deficiencies in using the Physician&#... more Bravos for Cohen and Insel! 1 They correctly identify major deficiencies in using the Physician's Desk Reference 2 ( PDR ) and make recommendations for improvement. They ask in their article, "Without the PDR or similar equivalent, where would physicians derive drug information and would it be an improvement?" They recommend a number of well-meaning improvements in the way the PDR is put together; however, because of the legal- and consumer-oriented pharmaceutical manufacturers' frame of reference, I doubt that such recommendations will ever be carried out. What I have done, and recommend that other physicians and institutions do, is to use the American Hospital Formulary Service information books, eg, AHFS Drug Information 3 ). Every year, I get a new book that costs just under $100. Updates are sent to me throughout the year. The books, and the updates, do a great job of discussing actions of pharmaceutical agents, side effects, contraindications, drug
JAMA: The Journal of the American Medical Association, 1979
To the Editor.— I was pleased to see the excellent article by Siegel et al (241:391, 1979). The p... more To the Editor.— I was pleased to see the excellent article by Siegel et al (241:391, 1979). The problem of exercise related to hematuria has long been of interest to urologists. With the increasing popularity of running in this country in the last several years, the association of gross hematuria with jogging and, more specifically, with marathon running is becoming a more frequently seen problem in the office of the urologist. The syndrome that the authors describe does indeed appear to have a different cause than the renal-based hematurias previously associated with contact sports, particularly boxing. However, I think a word of caution is in order, in that the cause suggested by Blacklock (their reference 3), trauma at the bladder neck area related to the pressure of the interabdominal contents transferred through the posterior bladder wall and to the bladder neck area as being the cause of the bleeding, is
Abstract Aims Type-2 diabetes mellitus (T2DM) is a common health condition which prevalence incre... more Abstract Aims Type-2 diabetes mellitus (T2DM) is a common health condition which prevalence increases with age. Besides lifestyle modifications, passive heating could be a promising intervention to improve glycemic control. This study aimed to assess the efficacy of passive heat therapy on glycemic and cardiovascular parameters, and body weight among patients with T2DM. Methods A systematic review and meta-analysis were reported according to PRISMA Statement. We conducted a systematic search in three databases (MEDLINE, Embase, CENTRAL) from inception to 19 August 2021. We included interventional studies reporting on T2DM patients treated with heat therapy. The main outcomes were the changes in pre-and post-treatment cardiometabolic parameters (fasting plasma glucose, glycated plasma hemoglobin, and triglyceride). For these continuous variables, weighted mean differences (WMD) with 95% confidence intervals (CIs) were calculated. Study protocol number: CRD42020221500. Results Five studies were included in the qualitative and quantitative synthesis, respectively. The results showed a not significant difference in the hemoglobin A1c [WMD −0.549%, 95% CI (−1.262, 0.164), p = 0.131], fasting glucose [WMD −0.290 mmol/l, 95% CI (−0.903, 0.324), p = 0.355]. Triglyceride [WMD 0.035 mmol/l, 95% CI (−0.130, 0.200), p = 0.677] levels were comparable regarding the pre-, and post intervention values. Conclusion Passive heating can be beneficial for patients with T2DM since the slight improvement in certain cardiometabolic parameters support that. However, further randomized controlled trials with longer intervention and follow-up periods are needed to confirm the beneficial effect of passive heat therapy.
The classic heat shock (stress) response (HSR) was originally attributed to protein denaturation.... more The classic heat shock (stress) response (HSR) was originally attributed to protein denaturation. However, heat shock protein (Hsp) induction occurs in many circumstances where no protein denaturation is observed. Recently considerable evidence has been accumulated to the favor of the "Membrane Sensor Hypothesis" which predicts that the level of Hsps can be changed as a result of alterations to the plasma membrane. This is especially pertinent to mild heat shock, such as occurs in fever. In this condition the sensitivity of many transient receptor potential (TRP) channels is particularly notable. Small temperature stresses can modulate TRP gating significantly and this is influenced by lipids. In addition, stress hormones often modify plasma membrane structure and function and thus initiate a cascade of events, which may affect HSR. The major transactivator heat shock factor-1 integrates the signals originating from the plasma membrane and orchestrates the expression of in...
The effect of exercise upon the uptake of radioiodine by the thyroid was examined in both rats an... more The effect of exercise upon the uptake of radioiodine by the thyroid was examined in both rats and humans. Rats that exercised intermittently on a mechanical wheel for a period of 20 days had significantly lower uptake values (p < 0.0001) than sedentary controls. Human volunteers that ran at least ten miles/week had a lower mean 24-hr uptake value (8.0 +/- 2.8%) than nonexercising subjects (14.3 +/- 5.1%, p < 0.01). Other thyroid function studies (thyroxine, triiodothyronine, triiodothyronine resin uptake, thyroid-stimulating hormone) did not differ significantly between the exercising and nonexercising groups. These studies suggest that exercise significantly alters thyroid iodine economy.
Bravos for Cohen and Insel! 1 They correctly identify major deficiencies in using the Physician&#... more Bravos for Cohen and Insel! 1 They correctly identify major deficiencies in using the Physician's Desk Reference 2 ( PDR ) and make recommendations for improvement. They ask in their article, "Without the PDR or similar equivalent, where would physicians derive drug information and would it be an improvement?" They recommend a number of well-meaning improvements in the way the PDR is put together; however, because of the legal- and consumer-oriented pharmaceutical manufacturers' frame of reference, I doubt that such recommendations will ever be carried out. What I have done, and recommend that other physicians and institutions do, is to use the American Hospital Formulary Service information books, eg, AHFS Drug Information 3 ). Every year, I get a new book that costs just under $100. Updates are sent to me throughout the year. The books, and the updates, do a great job of discussing actions of pharmaceutical agents, side effects, contraindications, drug
JAMA: The Journal of the American Medical Association, 1979
To the Editor.— I was pleased to see the excellent article by Siegel et al (241:391, 1979). The p... more To the Editor.— I was pleased to see the excellent article by Siegel et al (241:391, 1979). The problem of exercise related to hematuria has long been of interest to urologists. With the increasing popularity of running in this country in the last several years, the association of gross hematuria with jogging and, more specifically, with marathon running is becoming a more frequently seen problem in the office of the urologist. The syndrome that the authors describe does indeed appear to have a different cause than the renal-based hematurias previously associated with contact sports, particularly boxing. However, I think a word of caution is in order, in that the cause suggested by Blacklock (their reference 3), trauma at the bladder neck area related to the pressure of the interabdominal contents transferred through the posterior bladder wall and to the bladder neck area as being the cause of the bleeding, is
Abstract Aims Type-2 diabetes mellitus (T2DM) is a common health condition which prevalence incre... more Abstract Aims Type-2 diabetes mellitus (T2DM) is a common health condition which prevalence increases with age. Besides lifestyle modifications, passive heating could be a promising intervention to improve glycemic control. This study aimed to assess the efficacy of passive heat therapy on glycemic and cardiovascular parameters, and body weight among patients with T2DM. Methods A systematic review and meta-analysis were reported according to PRISMA Statement. We conducted a systematic search in three databases (MEDLINE, Embase, CENTRAL) from inception to 19 August 2021. We included interventional studies reporting on T2DM patients treated with heat therapy. The main outcomes were the changes in pre-and post-treatment cardiometabolic parameters (fasting plasma glucose, glycated plasma hemoglobin, and triglyceride). For these continuous variables, weighted mean differences (WMD) with 95% confidence intervals (CIs) were calculated. Study protocol number: CRD42020221500. Results Five studies were included in the qualitative and quantitative synthesis, respectively. The results showed a not significant difference in the hemoglobin A1c [WMD −0.549%, 95% CI (−1.262, 0.164), p = 0.131], fasting glucose [WMD −0.290 mmol/l, 95% CI (−0.903, 0.324), p = 0.355]. Triglyceride [WMD 0.035 mmol/l, 95% CI (−0.130, 0.200), p = 0.677] levels were comparable regarding the pre-, and post intervention values. Conclusion Passive heating can be beneficial for patients with T2DM since the slight improvement in certain cardiometabolic parameters support that. However, further randomized controlled trials with longer intervention and follow-up periods are needed to confirm the beneficial effect of passive heat therapy.
The classic heat shock (stress) response (HSR) was originally attributed to protein denaturation.... more The classic heat shock (stress) response (HSR) was originally attributed to protein denaturation. However, heat shock protein (Hsp) induction occurs in many circumstances where no protein denaturation is observed. Recently considerable evidence has been accumulated to the favor of the "Membrane Sensor Hypothesis" which predicts that the level of Hsps can be changed as a result of alterations to the plasma membrane. This is especially pertinent to mild heat shock, such as occurs in fever. In this condition the sensitivity of many transient receptor potential (TRP) channels is particularly notable. Small temperature stresses can modulate TRP gating significantly and this is influenced by lipids. In addition, stress hormones often modify plasma membrane structure and function and thus initiate a cascade of events, which may affect HSR. The major transactivator heat shock factor-1 integrates the signals originating from the plasma membrane and orchestrates the expression of in...
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