Background Tumor suppressor genes p53 and p16 INK4a and the proto-oncogene MDM2 are considered to... more Background Tumor suppressor genes p53 and p16 INK4a and the proto-oncogene MDM2 are considered to be essential G1 cell cycle regulatory genes whose loss of function is associated with ESCC carcinogenesis. We assessed the aberrant methylation of the p16 gene and its impact on p16 INK4a protein expression and correlations with p53 and MDM2 protein expressions in patients with ESCC in the Golestan province of northeastern Iran in which ESCC has the highest incidence of cancer, well above the world average.
Background Previous reports show a high proportion of young CRC patients in Iran. In this study w... more Background Previous reports show a high proportion of young CRC patients in Iran. In this study we aim to look for the clustering of colorectal cancer in families of a series of CRC patients from Iran. Methods The family history of cancer is traced in 449 CRC patients of which 112 were 45 yrs or younger and 337 were older than 45 yrs at time of diagnosis. The patients were admitted in two hospitals in Tehran, during a 4-year period. Results Clinical diagnosis of HNPCC was established in 21 (4.7%) probands.
The hepatitis B virus (HBV) is one of the most common chronic pathogens in the world. Over 2 bill... more The hepatitis B virus (HBV) is one of the most common chronic pathogens in the world. Over 2 billion of the world's population have been exposed to this virus. About 350 million of these, making 5% of the world's population, are chronic carriers. 1 Annually up to 1 million of this population die due to the consequences of this infection such as cirrhosis and hepatocellular carcinoma. 2 The HBV is 100 time more infectious than HIV (Table 1).
Background: There are no population-based data available for cancer in Tehran, a city that includ... more Background: There are no population-based data available for cancer in Tehran, a city that includes almost 10% of the Iranian population. This is the first report of cancer incidence in Tehran from a population-based cancer registry for the period of 1998–2001. Methods: The cancer registry collects data on all new cases of cancer diagnosed in the resident population of Tehran metropolitan area.
Background/Aims: Ardabil Province, in northwestern Iran, has the highest rate of gastric (predomi... more Background/Aims: Ardabil Province, in northwestern Iran, has the highest rate of gastric (predominantly cardia) adenocarcinoma in Iran. This study aimed to investigate the feasibility of endoscopic screening and to look for associated Helicobacter pylori infection and gastric precancerous lesions.
AIM: The healthy ranges for serum alanine aminotransferase (ALT) levels are less well studied. Th... more AIM: The healthy ranges for serum alanine aminotransferase (ALT) levels are less well studied. The aim of this study was to define the upper limit of normal (ULN) for serum ALT levels, and to assess factors associated with serum ALT activity in apparently healthy blood donors. METHODS: A total of 1 939 blood donors were included. ALT measurements were performed for all cases using the same laboratory method. Healthy ranges for ALT levels were computed from the population at the lowest risk for liver disease.
Abstract Previous studies have shown that oesophageal and gastric cancers are the most common cau... more Abstract Previous studies have shown that oesophageal and gastric cancers are the most common causes of cancer death in the Golestan Province, Iran. In 2001, we established Atrak Clinic, a referral clinic for gastrointestinal (GI) diseases in Gonbad, the major city of eastern Golestan, which has permitted, for the first time in this region, endoscopic localisation and histologic examination of upper GI cancers.
AIM: Both observational and experimental studies have shown that higher selenium status reduces t... more AIM: Both observational and experimental studies have shown that higher selenium status reduces the risk of upper gastrointestinal cancers in selenium deficient populations. Recent cancer registry data have shown very different rates of esophageal cancer (EC) and gastric cancer (GC) in four Provinces of Iran, namely Ardabil, Mazandaran, Golestan, and Kerman.
Golestan Province in northeastern Iran has one of the highest rates of esophageal squamous cell c... more Golestan Province in northeastern Iran has one of the highest rates of esophageal squamous cell cancer in the world. This article reviews the studies conducted on esophageal squamous cell cancer in this area and summarizes the data on epidemiologic patterns, incidence trends, and etiology of esophageal squamous cell cancer in this province.
Objective To investigate the association between tea drinking habits in Golestan province, northe... more Objective To investigate the association between tea drinking habits in Golestan province, northern Iran, and risk of oesophageal squamous cell carcinoma. Design Population based case-control study. In addition, patterns of tea drinking and temperature at which tea was drunk were measured among healthy participants in a cohort study. Setting Golestan province, northern Iran, an area with a high incidence of oesophageal squamous cell carcinoma.
The very high incidence of oesophageal squamous cell carcinoma (ESCC) in Golestan Province in nor... more The very high incidence of oesophageal squamous cell carcinoma (ESCC) in Golestan Province in northeastern Iran was suggested by studies in the 1970s as partly due to opium use, which is not uncommon in this area, but based on limited numbers. From December 2003 to June 2007, we administered a validated structured questionnaire to 300 ESCC cases and 571 controls, matched on neighbourhood of residence, age (±2 years), and sex.
Background HBV infection is a serious global heath problem. It is crucial to monitor this disease... more Background HBV infection is a serious global heath problem. It is crucial to monitor this disease more closely with a non-invasive marker in clinical trials. We aimed to evaluate the predictive value of serum hyaluronate for the presence of extensive liver fibrosis and inflammation. Methods 28 healthy volunteers and 65 patients with HBeAg negative chronic hepatitis B were enrolled. Liver biopsies scored according to Ishak system.
Although the global incidence of gastric cancer has been decreased dramatically in recent decades... more Although the global incidence of gastric cancer has been decreased dramatically in recent decades, it is the most common cancer in north and northwest Iran. The wide variation in incidence across different geographical areas and higher proportion of cardia cancer are two main characteristics of gastric cancer in Iran. Current investigations indicate that a high prevalence of H. pylori infection, high dietary intake of salt and smoking are the main environmental factors of gastric cancer in Iran.
Abstract To investigate the incidence of oesophageal cancer (EC) in the Golestan province of Nort... more Abstract To investigate the incidence of oesophageal cancer (EC) in the Golestan province of North-East Iran, we invited 1349 rural and urban inhabitants of Golestan province aged 35–80 to undergo extensive lifestyle interviews and to provide biological samples. The interview was repeated on a subset of 130 participants to assess reliability of questionnaire and medical information. Temperature at which tea was consumed was measured on two occasions by 110 subjects.
The prevalence of overweight and obesity in most developed and developing countries have been inc... more The prevalence of overweight and obesity in most developed and developing countries have been increasing markedly over the past two decades. This increase includes all ages, genders, racial and ethnic groups, income, and educational levels. A variety of genetic, environmental, physiological, psychological and sociocultural factors influence the development of obesity. Iran like many other developing countries is now experiencing the global epidemic of obesity and its consequences.
Background: Hepatitis B virus infection is a very common cause of chronic liver disease worldwide... more Background: Hepatitis B virus infection is a very common cause of chronic liver disease worldwide. It is estimated that 3% of Iranians are chronically infected with hepatitis B virus. Current population-based studies on both rural and urban prevalence of hepatitis B virus infection in Iran are sparse with results that do not always agree. We performed this study to find the prevalence of hepatitis B surface antigen, anti-hepatitis B core antibody, and associated factors in the general population of three provinces of Iran.
Background: In the West, the subsite incidence of gastric cancer has changed in recent decades, w... more Background: In the West, the subsite incidence of gastric cancer has changed in recent decades, with cancer of the cardia increasing in incidence and that of the more distal stomach decreasing. NW Iran has a very high incidence of upper gastrointestinal cancer and we have examined the anatomical site specific incidence in this geographical region.
Background: Upper gastrointestinal cancer is the most common cancer in Ardabil Province, North-We... more Background: Upper gastrointestinal cancer is the most common cancer in Ardabil Province, North-West of Iran, accounting for more than 50% of all cancer deaths in this area. We conducted this study to determine the present survival rate of patients with esophageal and gastric cancers before launching interventional studies.
AIM: To assess the proteome of normal versus tumor tissue in squamous cell carcinoma of the esoph... more AIM: To assess the proteome of normal versus tumor tissue in squamous cell carcinoma of the esophagus (SCCE) in Iranian patients and compare our results with former reports by using proteomics. METHODS: Protein was extracted from normal and tumor tissues. Two dimensional electrophoresis was carried out and spots with differential expression were identified with mass spectrometry. RNA extraction and RT-PCR along with immunodetection were performed.
Abstract We tested the association between tooth loss and oral hygiene and the risk of esophageal... more Abstract We tested the association between tooth loss and oral hygiene and the risk of esophageal squamous cell carcinoma (ESCC) in people living in a high-risk area of Iran. We used a case-control study of pathologically confirmed ESCC cases (n= 283) and controls (n= 560) matched on sex, age, and neighborhood. Subjects with ESCC had significantly more decayed, missing, or filled teeth (DMFT) with a median (interquartile range) of 31 (23-32) compared with controls 28 (16-32; P= 0.0045).
Background Tumor suppressor genes p53 and p16 INK4a and the proto-oncogene MDM2 are considered to... more Background Tumor suppressor genes p53 and p16 INK4a and the proto-oncogene MDM2 are considered to be essential G1 cell cycle regulatory genes whose loss of function is associated with ESCC carcinogenesis. We assessed the aberrant methylation of the p16 gene and its impact on p16 INK4a protein expression and correlations with p53 and MDM2 protein expressions in patients with ESCC in the Golestan province of northeastern Iran in which ESCC has the highest incidence of cancer, well above the world average.
Background Previous reports show a high proportion of young CRC patients in Iran. In this study w... more Background Previous reports show a high proportion of young CRC patients in Iran. In this study we aim to look for the clustering of colorectal cancer in families of a series of CRC patients from Iran. Methods The family history of cancer is traced in 449 CRC patients of which 112 were 45 yrs or younger and 337 were older than 45 yrs at time of diagnosis. The patients were admitted in two hospitals in Tehran, during a 4-year period. Results Clinical diagnosis of HNPCC was established in 21 (4.7%) probands.
The hepatitis B virus (HBV) is one of the most common chronic pathogens in the world. Over 2 bill... more The hepatitis B virus (HBV) is one of the most common chronic pathogens in the world. Over 2 billion of the world's population have been exposed to this virus. About 350 million of these, making 5% of the world's population, are chronic carriers. 1 Annually up to 1 million of this population die due to the consequences of this infection such as cirrhosis and hepatocellular carcinoma. 2 The HBV is 100 time more infectious than HIV (Table 1).
Background: There are no population-based data available for cancer in Tehran, a city that includ... more Background: There are no population-based data available for cancer in Tehran, a city that includes almost 10% of the Iranian population. This is the first report of cancer incidence in Tehran from a population-based cancer registry for the period of 1998–2001. Methods: The cancer registry collects data on all new cases of cancer diagnosed in the resident population of Tehran metropolitan area.
Background/Aims: Ardabil Province, in northwestern Iran, has the highest rate of gastric (predomi... more Background/Aims: Ardabil Province, in northwestern Iran, has the highest rate of gastric (predominantly cardia) adenocarcinoma in Iran. This study aimed to investigate the feasibility of endoscopic screening and to look for associated Helicobacter pylori infection and gastric precancerous lesions.
AIM: The healthy ranges for serum alanine aminotransferase (ALT) levels are less well studied. Th... more AIM: The healthy ranges for serum alanine aminotransferase (ALT) levels are less well studied. The aim of this study was to define the upper limit of normal (ULN) for serum ALT levels, and to assess factors associated with serum ALT activity in apparently healthy blood donors. METHODS: A total of 1 939 blood donors were included. ALT measurements were performed for all cases using the same laboratory method. Healthy ranges for ALT levels were computed from the population at the lowest risk for liver disease.
Abstract Previous studies have shown that oesophageal and gastric cancers are the most common cau... more Abstract Previous studies have shown that oesophageal and gastric cancers are the most common causes of cancer death in the Golestan Province, Iran. In 2001, we established Atrak Clinic, a referral clinic for gastrointestinal (GI) diseases in Gonbad, the major city of eastern Golestan, which has permitted, for the first time in this region, endoscopic localisation and histologic examination of upper GI cancers.
AIM: Both observational and experimental studies have shown that higher selenium status reduces t... more AIM: Both observational and experimental studies have shown that higher selenium status reduces the risk of upper gastrointestinal cancers in selenium deficient populations. Recent cancer registry data have shown very different rates of esophageal cancer (EC) and gastric cancer (GC) in four Provinces of Iran, namely Ardabil, Mazandaran, Golestan, and Kerman.
Golestan Province in northeastern Iran has one of the highest rates of esophageal squamous cell c... more Golestan Province in northeastern Iran has one of the highest rates of esophageal squamous cell cancer in the world. This article reviews the studies conducted on esophageal squamous cell cancer in this area and summarizes the data on epidemiologic patterns, incidence trends, and etiology of esophageal squamous cell cancer in this province.
Objective To investigate the association between tea drinking habits in Golestan province, northe... more Objective To investigate the association between tea drinking habits in Golestan province, northern Iran, and risk of oesophageal squamous cell carcinoma. Design Population based case-control study. In addition, patterns of tea drinking and temperature at which tea was drunk were measured among healthy participants in a cohort study. Setting Golestan province, northern Iran, an area with a high incidence of oesophageal squamous cell carcinoma.
The very high incidence of oesophageal squamous cell carcinoma (ESCC) in Golestan Province in nor... more The very high incidence of oesophageal squamous cell carcinoma (ESCC) in Golestan Province in northeastern Iran was suggested by studies in the 1970s as partly due to opium use, which is not uncommon in this area, but based on limited numbers. From December 2003 to June 2007, we administered a validated structured questionnaire to 300 ESCC cases and 571 controls, matched on neighbourhood of residence, age (±2 years), and sex.
Background HBV infection is a serious global heath problem. It is crucial to monitor this disease... more Background HBV infection is a serious global heath problem. It is crucial to monitor this disease more closely with a non-invasive marker in clinical trials. We aimed to evaluate the predictive value of serum hyaluronate for the presence of extensive liver fibrosis and inflammation. Methods 28 healthy volunteers and 65 patients with HBeAg negative chronic hepatitis B were enrolled. Liver biopsies scored according to Ishak system.
Although the global incidence of gastric cancer has been decreased dramatically in recent decades... more Although the global incidence of gastric cancer has been decreased dramatically in recent decades, it is the most common cancer in north and northwest Iran. The wide variation in incidence across different geographical areas and higher proportion of cardia cancer are two main characteristics of gastric cancer in Iran. Current investigations indicate that a high prevalence of H. pylori infection, high dietary intake of salt and smoking are the main environmental factors of gastric cancer in Iran.
Abstract To investigate the incidence of oesophageal cancer (EC) in the Golestan province of Nort... more Abstract To investigate the incidence of oesophageal cancer (EC) in the Golestan province of North-East Iran, we invited 1349 rural and urban inhabitants of Golestan province aged 35–80 to undergo extensive lifestyle interviews and to provide biological samples. The interview was repeated on a subset of 130 participants to assess reliability of questionnaire and medical information. Temperature at which tea was consumed was measured on two occasions by 110 subjects.
The prevalence of overweight and obesity in most developed and developing countries have been inc... more The prevalence of overweight and obesity in most developed and developing countries have been increasing markedly over the past two decades. This increase includes all ages, genders, racial and ethnic groups, income, and educational levels. A variety of genetic, environmental, physiological, psychological and sociocultural factors influence the development of obesity. Iran like many other developing countries is now experiencing the global epidemic of obesity and its consequences.
Background: Hepatitis B virus infection is a very common cause of chronic liver disease worldwide... more Background: Hepatitis B virus infection is a very common cause of chronic liver disease worldwide. It is estimated that 3% of Iranians are chronically infected with hepatitis B virus. Current population-based studies on both rural and urban prevalence of hepatitis B virus infection in Iran are sparse with results that do not always agree. We performed this study to find the prevalence of hepatitis B surface antigen, anti-hepatitis B core antibody, and associated factors in the general population of three provinces of Iran.
Background: In the West, the subsite incidence of gastric cancer has changed in recent decades, w... more Background: In the West, the subsite incidence of gastric cancer has changed in recent decades, with cancer of the cardia increasing in incidence and that of the more distal stomach decreasing. NW Iran has a very high incidence of upper gastrointestinal cancer and we have examined the anatomical site specific incidence in this geographical region.
Background: Upper gastrointestinal cancer is the most common cancer in Ardabil Province, North-We... more Background: Upper gastrointestinal cancer is the most common cancer in Ardabil Province, North-West of Iran, accounting for more than 50% of all cancer deaths in this area. We conducted this study to determine the present survival rate of patients with esophageal and gastric cancers before launching interventional studies.
AIM: To assess the proteome of normal versus tumor tissue in squamous cell carcinoma of the esoph... more AIM: To assess the proteome of normal versus tumor tissue in squamous cell carcinoma of the esophagus (SCCE) in Iranian patients and compare our results with former reports by using proteomics. METHODS: Protein was extracted from normal and tumor tissues. Two dimensional electrophoresis was carried out and spots with differential expression were identified with mass spectrometry. RNA extraction and RT-PCR along with immunodetection were performed.
Abstract We tested the association between tooth loss and oral hygiene and the risk of esophageal... more Abstract We tested the association between tooth loss and oral hygiene and the risk of esophageal squamous cell carcinoma (ESCC) in people living in a high-risk area of Iran. We used a case-control study of pathologically confirmed ESCC cases (n= 283) and controls (n= 560) matched on sex, age, and neighborhood. Subjects with ESCC had significantly more decayed, missing, or filled teeth (DMFT) with a median (interquartile range) of 31 (23-32) compared with controls 28 (16-32; P= 0.0045).
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Papers by Reza Malekzadeh