A GIS-based approach has been used to assess existing and potential near-future coastal habitats ... more A GIS-based approach has been used to assess existing and potential near-future coastal habitats under different sea-level rise and management scenarios. For six local case studies on the south coast of the UK, difficulties in meeting the requirements of the EC Habitats Directive within individual case study areas were found. The most significant issues were related to intertidal saltmarsh and
Visual arrestin-1 plays a key role in the rapid and reproducible shutoff of rhodopsin signaling. ... more Visual arrestin-1 plays a key role in the rapid and reproducible shutoff of rhodopsin signaling. Its highly selective binding to light-activated phosphorylated rhodopsin is an integral part of the functional perfection of rod photoreceptors. Structure-function studies revealed key elements of the sophisticated molecular mechanism ensuring arrestin-1 selectivity and paved the way to the targeted manipulation of the arrestin-1 molecule to design mutants that can compensate for congenital defects in rhodopsin phosphorylation. Arrestin-1 self-association and light-dependent translocation in photoreceptor cells work together to keep a constant supply of active rhodopsin-binding arrestin-1 monomer in the outer segment. Recent discoveries of arrestin-1 interaction with other signaling proteins suggest that it is a much more versatile signaling regulator than previously thought, affecting the function of the synaptic terminals and rod survival. Elucidation of the fine molecular mechanisms of arrestin-1 interactions with rhodopsin and other binding partners is necessary for the comprehensive understanding of rod function and for devising novel molecular tools and therapeutic approaches to the treatment of visual disorders.
A GIS-based approach has been used to assess existing and potential near-future coastal habitats ... more A GIS-based approach has been used to assess existing and potential near-future coastal habitats under different sea-level rise and management scenarios. For six local case studies on the south coast of the UK, difficulties in meeting the requirements of the EC Habitats Directive within individual case study areas were found. The most significant issues were related to intertidal saltmarsh and
Visual arrestin-1 plays a key role in the rapid and reproducible shutoff of rhodopsin signaling. ... more Visual arrestin-1 plays a key role in the rapid and reproducible shutoff of rhodopsin signaling. Its highly selective binding to light-activated phosphorylated rhodopsin is an integral part of the functional perfection of rod photoreceptors. Structure-function studies revealed key elements of the sophisticated molecular mechanism ensuring arrestin-1 selectivity and paved the way to the targeted manipulation of the arrestin-1 molecule to design mutants that can compensate for congenital defects in rhodopsin phosphorylation. Arrestin-1 self-association and light-dependent translocation in photoreceptor cells work together to keep a constant supply of active rhodopsin-binding arrestin-1 monomer in the outer segment. Recent discoveries of arrestin-1 interaction with other signaling proteins suggest that it is a much more versatile signaling regulator than previously thought, affecting the function of the synaptic terminals and rod survival. Elucidation of the fine molecular mechanisms of arrestin-1 interactions with rhodopsin and other binding partners is necessary for the comprehensive understanding of rod function and for devising novel molecular tools and therapeutic approaches to the treatment of visual disorders.
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Papers by Susan Hanson