Male breast cancer remains under diagnosed and due to delays in diagnosis is often also under tre... more Male breast cancer remains under diagnosed and due to delays in diagnosis is often also under treated. Papillary carcinoma of the male breast is a rare neoplasm. Only a few cases have been reported in the literature. Since papillary carcinoma has a favourable prognosis as compar ed to other histopathological subtypes, an accurate diagnosis is essential. Papillary lesions of the male breast comprise a spectrum of lesions ranging from benign intraductal papilloma to intraductal papillary carcinoma and invasive papillary carcinoma. We describe a case of male breast papillary carcinoma diagnosed by fine-needle aspiration cytology (FNAC). A 70 year old man presented with a subareolar painless mass in left breast. FNAC examination revealed a cellular aspirate and the diagnosis of papillary carcinoma was rendere d. The patient underwent modified radical mastectomy for left breast and the histopathology of resected specimen confirmed the FNAC diagnosis.
Oncology, Gastroenterology and Hepatology Reports, 2013
Primary splenic lymphoma is defined as generalized lymphoma with splenic involvement as the domin... more Primary splenic lymphoma is defined as generalized lymphoma with splenic involvement as the dominant feature. Primary splenic lymphoma is an infrequent disease. It comprises less than 1% of the all malignant lymphoma. We present a case of 55 years old male with fever, pain and lump in abdomen of 1 month duration. The purpose of this paper is to report a rare occurrence of primary splenic lymphoma and to demonstrate the possibility of it misdiagnosed as splenic abscess clinically and on imaging.
Ameloblastoma is a tumour of odontogenic epithelium that occurs in the jaws. We describe a case o... more Ameloblastoma is a tumour of odontogenic epithelium that occurs in the jaws. We describe a case of an ameloblastoma of the mandible that was diagnosed by fine needle aspiration cytology (FNAC). The biopsy for preope rative diagnosis would be cumbersome and traumatic, as surgery is the mainstay of treatment. So the FNAC was performed and the aspirated material from the left mandibular swelling showed benign basaloid epithelial cells in sheets and clusters with focal peripheral palisading. A diagnosis of ameloblastoma was done. Histological examination of the resected specimen confirmed the cytological diagnosis.
Lipoma of the breast often causes diagnostic and therapeutic uncertainty. Clinically it may be di... more Lipoma of the breast often causes diagnostic and therapeutic uncertainty. Clinically it may be difficult to distinguish a Lipoma from other conditions. Lipoma of the breast is usually, benign neoplasm which can be treated by simple excision. Diagnosis of breast lipoma is difficult because of normal fatty composition of the breast. We present a case of 68 year old female with a painless lump in right breast.
Ameloblastoma is a tumour of odontogenic epithelium that occurs in the jaws. We describe a case o... more Ameloblastoma is a tumour of odontogenic epithelium that occurs in the jaws. We describe a case of an ameloblastoma of the mandible that was diagnosed by fine needle aspiration cytology (FNAC). The biopsy for preope rative diagnosis would be cumbersome and traumatic, as surgery is the mainstay of treatment. So the FNAC was performed and the aspirated material from the left mandibular swelling showed benign basaloid epithelial cells in sheets and clusters with focal peripheral palisading. A diagnosis of ameloblastoma was done. Histological examination of the resected specimen confirmed the cytological diagnosis.
Objective : To study gross and microscopic pathology in various organs in serologically proven de... more Objective : To study gross and microscopic pathology in various organs in serologically proven dengue related deaths. Materials &Methods : Autopsies carried out in fatal dengue cases from January 2015 to December 2016 were analysed. Results : Complete autopsies were conducted in all 8 cases of dengue fatalities. Edema and intrapulmonary hemorrhage were significant pathologies in lungs. Acute tubular necrosis of kidney was noted in majority of cases. Hemorrhage in the gastrointestinal mucosa, hepatic necrosis and myocardial interstitial haemorrhage were occasionally observed. Conclusion :Dengue fever should be regarded as a multiorgan infection. Autopsy studies will enlighten pathology in different organs. A better understanding of changes in different organs in dengue fever will help in the management and prevent fatalities.
Cystadenofibroma, a rare variant of benign cystoma of the ovary is generally regarded as a nonfun... more Cystadenofibroma, a rare variant of benign cystoma of the ovary is generally regarded as a nonfunctioning benign tumour. Small tumours of this kind are relatively common, but large, bilateral and functioning tumours are extremely rare. A 48 year old postmenopausal woman presented with bleeding per vagina and abdominal pain. We report a case of bilateral cystodenofibromas of the ovaries, producing oestrogenic substance, in postmenopausa l woman.
International journal of scientific research, 2020
Background Dengue fever is caused by dengue virus which is a mosquito borne pathogen and this dis... more Background Dengue fever is caused by dengue virus which is a mosquito borne pathogen and this disease is now endemic in India. This infection produces varied haematological changes in the patient which can at times be life threatening. The aim of this study was to identify these changes in serologically confirmed dengue cases. Methods 50 cases diagnosed as dengue based on NS1 antigen were analysed for haematological parameters which included haematocrit value , total leucocyte count, differential leucocyte count, platelet count and peripheral blood smear. Results Common haematological abnormalities detected were leucopenia, raised haematocrit, thrombocytopenia and presence of activated lymphocytes. Conclusion Hematological parameters play a key role in early diagnosis of dengue infection. Monitoring these parameters aids in effective management of patients and prevention of complications.
Male breast cancer remains under diagnosed and due to delays in diagnosis is often also under tre... more Male breast cancer remains under diagnosed and due to delays in diagnosis is often also under treated. Papillary carcinoma of the male breast is a rare neoplasm. Only a few cases have been reported in the literature. Since papillary carcinoma has a favourable prognosis as compar ed to other histopathological subtypes, an accurate diagnosis is essential. Papillary lesions of the male breast comprise a spectrum of lesions ranging from benign intraductal papilloma to intraductal papillary carcinoma and invasive papillary carcinoma. We describe a case of male breast papillary carcinoma diagnosed by fine-needle aspiration cytology (FNAC). A 70 year old man presented with a subareolar painless mass in left breast. FNAC examination revealed a cellular aspirate and the diagnosis of papillary carcinoma was rendere d. The patient underwent modified radical mastectomy for left breast and the histopathology of resected specimen confirmed the FNAC diagnosis.
Lipoma of the breast often causes diagnostic and therapeutic uncertainty. Clinically it may be di... more Lipoma of the breast often causes diagnostic and therapeutic uncertainty. Clinically it may be difficult to distinguish a Lipoma from other conditions. Lipoma of the breast is usually, benign neoplasm which can be treated by simple excision. Diagnosis of breast lipoma is difficult because of normal fatty composition of the breast. We present a case of 68 year old female with a painless lump in right breast.
Desmoplastic ganglioglioma is a rare markedly desmoplastic variant of ganglioglioma that usually ... more Desmoplastic ganglioglioma is a rare markedly desmoplastic variant of ganglioglioma that usually presents in the first year of life. It is a mixed glial and cerebral neuronal tumour. A few cases of desmoplastic ganglioglioma have been reported in non infantile patients. We report a case of a 17 year old girl who presented with a right temporal lobe space occupying lesion in the outer third of right sphenoid wing enhancing well on contrast, attached to pia. Histological examination revealed a cellular glioneuronal tumour showing nuclear atypia. Atypical ganglion cells were present in the tumour. Immunohistochemistry revealed GFAP positive glial component and synaptophysin and chromogranin positive ganglion cells. This case confirms that desmoplastic ganglioglioma is an entity that can be seen even in young adults.
Adenocarcinoma of rete testis, a rare tumour warrants a distinctive diagnosis and needs to be dif... more Adenocarcinoma of rete testis, a rare tumour warrants a distinctive diagnosis and needs to be differentiated from other malignant tumours of testis in view of its poor prognosis and the fact that no form of therapy can influence the final outcome. These tumour almost immediately metastasize to various sites and the expected survival is less than one year. They have a distinctive gross appearance as they are centred in the region of hilus of testis and the tumour is distinct from the testicular parenchyma. W e report a case of a 50 year old male who presented with a painless, hard scrotal swelling. Microscopic examination revealed a papillary adenocarcinoma of rete testis.
We report a case of conjunctival cysticercus cellulosae cyst in a 22 year old male from low Socio... more We report a case of conjunctival cysticercus cellulosae cyst in a 22 year old male from low Socio-economic class. The excised mass was 0.4 x 0.6 cm, greyish white in colour. Histopathology revealed a conjunctival cyst with a parasite embedded within, showing morphological features of cysticercus cellulosae.
Mucormycosis (previously referred to as zygomycosis) is a rare but fatal infection caused by fung... more Mucormycosis (previously referred to as zygomycosis) is a rare but fatal infection caused by fungal species of the order Mucorales, family Mucoraceae. It is usually seen in immunocompromised individuals, such as those suffering from diabetes, recipients of organ transplants or patients on chemotherapy. Depending on the site affected, the disease can be pulmonary, cutaneous, rhinocerebral, gastrointestinal or disseminated. We present the case of a 40-year old male who was a known chronic alcoholic and was admitted with haematemesis from oesophageal varices for which endoscopic banding was done. However, his condition continued to deteriorate. He subsequently succumbed and a gastric ulcer due to mucormycosis was found among other observations.
This study was performed to quantify the number of neutrophils and eosinophils in nasal secretion... more This study was performed to quantify the number of neutrophils and eosinophils in nasal secretions from paediatric patients with perennial rhinitis, under infected and non infected conditions, to differentiate infected bacterial from viral rhinitis and allergic from infected rhinitis. Nasal secretions and mucosal scrapings of 93 children up to 12 years with symptoms and signs of perennial rhinitis were subjected to cytological analysis. The smears were stained with H and E and 10 HPF’s were examined. Grading was done utilizing the semiquantitative nasal cytology grading score of Meltzer. 21 healthy children were used as controls. The material was also subjected to bacteriologic al analysis. Additional ancillary investigations done were a CBC and an absolute eosinophil count. There were distinctive differences in the grading scores between the cases of perennial rhinitis and the control groups, both were significantly higher in the former, we were able to differentiate between infect...
Male breast cancer remains under diagnosed and due to delays in diagnosis is often also under tre... more Male breast cancer remains under diagnosed and due to delays in diagnosis is often also under treated. Papillary carcinoma of the male breast is a rare neoplasm. Only a few cases have been reported in the literature. Since papillary carcinoma has a favourable prognosis as compar ed to other histopathological subtypes, an accurate diagnosis is essential. Papillary lesions of the male breast comprise a spectrum of lesions ranging from benign intraductal papilloma to intraductal papillary carcinoma and invasive papillary carcinoma. We describe a case of male breast papillary carcinoma diagnosed by fine-needle aspiration cytology (FNAC). A 70 year old man presented with a subareolar painless mass in left breast. FNAC examination revealed a cellular aspirate and the diagnosis of papillary carcinoma was rendere d. The patient underwent modified radical mastectomy for left breast and the histopathology of resected specimen confirmed the FNAC diagnosis.
Oncology, Gastroenterology and Hepatology Reports, 2013
Primary splenic lymphoma is defined as generalized lymphoma with splenic involvement as the domin... more Primary splenic lymphoma is defined as generalized lymphoma with splenic involvement as the dominant feature. Primary splenic lymphoma is an infrequent disease. It comprises less than 1% of the all malignant lymphoma. We present a case of 55 years old male with fever, pain and lump in abdomen of 1 month duration. The purpose of this paper is to report a rare occurrence of primary splenic lymphoma and to demonstrate the possibility of it misdiagnosed as splenic abscess clinically and on imaging.
Ameloblastoma is a tumour of odontogenic epithelium that occurs in the jaws. We describe a case o... more Ameloblastoma is a tumour of odontogenic epithelium that occurs in the jaws. We describe a case of an ameloblastoma of the mandible that was diagnosed by fine needle aspiration cytology (FNAC). The biopsy for preope rative diagnosis would be cumbersome and traumatic, as surgery is the mainstay of treatment. So the FNAC was performed and the aspirated material from the left mandibular swelling showed benign basaloid epithelial cells in sheets and clusters with focal peripheral palisading. A diagnosis of ameloblastoma was done. Histological examination of the resected specimen confirmed the cytological diagnosis.
Lipoma of the breast often causes diagnostic and therapeutic uncertainty. Clinically it may be di... more Lipoma of the breast often causes diagnostic and therapeutic uncertainty. Clinically it may be difficult to distinguish a Lipoma from other conditions. Lipoma of the breast is usually, benign neoplasm which can be treated by simple excision. Diagnosis of breast lipoma is difficult because of normal fatty composition of the breast. We present a case of 68 year old female with a painless lump in right breast.
Ameloblastoma is a tumour of odontogenic epithelium that occurs in the jaws. We describe a case o... more Ameloblastoma is a tumour of odontogenic epithelium that occurs in the jaws. We describe a case of an ameloblastoma of the mandible that was diagnosed by fine needle aspiration cytology (FNAC). The biopsy for preope rative diagnosis would be cumbersome and traumatic, as surgery is the mainstay of treatment. So the FNAC was performed and the aspirated material from the left mandibular swelling showed benign basaloid epithelial cells in sheets and clusters with focal peripheral palisading. A diagnosis of ameloblastoma was done. Histological examination of the resected specimen confirmed the cytological diagnosis.
Objective : To study gross and microscopic pathology in various organs in serologically proven de... more Objective : To study gross and microscopic pathology in various organs in serologically proven dengue related deaths. Materials &Methods : Autopsies carried out in fatal dengue cases from January 2015 to December 2016 were analysed. Results : Complete autopsies were conducted in all 8 cases of dengue fatalities. Edema and intrapulmonary hemorrhage were significant pathologies in lungs. Acute tubular necrosis of kidney was noted in majority of cases. Hemorrhage in the gastrointestinal mucosa, hepatic necrosis and myocardial interstitial haemorrhage were occasionally observed. Conclusion :Dengue fever should be regarded as a multiorgan infection. Autopsy studies will enlighten pathology in different organs. A better understanding of changes in different organs in dengue fever will help in the management and prevent fatalities.
Cystadenofibroma, a rare variant of benign cystoma of the ovary is generally regarded as a nonfun... more Cystadenofibroma, a rare variant of benign cystoma of the ovary is generally regarded as a nonfunctioning benign tumour. Small tumours of this kind are relatively common, but large, bilateral and functioning tumours are extremely rare. A 48 year old postmenopausal woman presented with bleeding per vagina and abdominal pain. We report a case of bilateral cystodenofibromas of the ovaries, producing oestrogenic substance, in postmenopausa l woman.
International journal of scientific research, 2020
Background Dengue fever is caused by dengue virus which is a mosquito borne pathogen and this dis... more Background Dengue fever is caused by dengue virus which is a mosquito borne pathogen and this disease is now endemic in India. This infection produces varied haematological changes in the patient which can at times be life threatening. The aim of this study was to identify these changes in serologically confirmed dengue cases. Methods 50 cases diagnosed as dengue based on NS1 antigen were analysed for haematological parameters which included haematocrit value , total leucocyte count, differential leucocyte count, platelet count and peripheral blood smear. Results Common haematological abnormalities detected were leucopenia, raised haematocrit, thrombocytopenia and presence of activated lymphocytes. Conclusion Hematological parameters play a key role in early diagnosis of dengue infection. Monitoring these parameters aids in effective management of patients and prevention of complications.
Male breast cancer remains under diagnosed and due to delays in diagnosis is often also under tre... more Male breast cancer remains under diagnosed and due to delays in diagnosis is often also under treated. Papillary carcinoma of the male breast is a rare neoplasm. Only a few cases have been reported in the literature. Since papillary carcinoma has a favourable prognosis as compar ed to other histopathological subtypes, an accurate diagnosis is essential. Papillary lesions of the male breast comprise a spectrum of lesions ranging from benign intraductal papilloma to intraductal papillary carcinoma and invasive papillary carcinoma. We describe a case of male breast papillary carcinoma diagnosed by fine-needle aspiration cytology (FNAC). A 70 year old man presented with a subareolar painless mass in left breast. FNAC examination revealed a cellular aspirate and the diagnosis of papillary carcinoma was rendere d. The patient underwent modified radical mastectomy for left breast and the histopathology of resected specimen confirmed the FNAC diagnosis.
Lipoma of the breast often causes diagnostic and therapeutic uncertainty. Clinically it may be di... more Lipoma of the breast often causes diagnostic and therapeutic uncertainty. Clinically it may be difficult to distinguish a Lipoma from other conditions. Lipoma of the breast is usually, benign neoplasm which can be treated by simple excision. Diagnosis of breast lipoma is difficult because of normal fatty composition of the breast. We present a case of 68 year old female with a painless lump in right breast.
Desmoplastic ganglioglioma is a rare markedly desmoplastic variant of ganglioglioma that usually ... more Desmoplastic ganglioglioma is a rare markedly desmoplastic variant of ganglioglioma that usually presents in the first year of life. It is a mixed glial and cerebral neuronal tumour. A few cases of desmoplastic ganglioglioma have been reported in non infantile patients. We report a case of a 17 year old girl who presented with a right temporal lobe space occupying lesion in the outer third of right sphenoid wing enhancing well on contrast, attached to pia. Histological examination revealed a cellular glioneuronal tumour showing nuclear atypia. Atypical ganglion cells were present in the tumour. Immunohistochemistry revealed GFAP positive glial component and synaptophysin and chromogranin positive ganglion cells. This case confirms that desmoplastic ganglioglioma is an entity that can be seen even in young adults.
Adenocarcinoma of rete testis, a rare tumour warrants a distinctive diagnosis and needs to be dif... more Adenocarcinoma of rete testis, a rare tumour warrants a distinctive diagnosis and needs to be differentiated from other malignant tumours of testis in view of its poor prognosis and the fact that no form of therapy can influence the final outcome. These tumour almost immediately metastasize to various sites and the expected survival is less than one year. They have a distinctive gross appearance as they are centred in the region of hilus of testis and the tumour is distinct from the testicular parenchyma. W e report a case of a 50 year old male who presented with a painless, hard scrotal swelling. Microscopic examination revealed a papillary adenocarcinoma of rete testis.
We report a case of conjunctival cysticercus cellulosae cyst in a 22 year old male from low Socio... more We report a case of conjunctival cysticercus cellulosae cyst in a 22 year old male from low Socio-economic class. The excised mass was 0.4 x 0.6 cm, greyish white in colour. Histopathology revealed a conjunctival cyst with a parasite embedded within, showing morphological features of cysticercus cellulosae.
Mucormycosis (previously referred to as zygomycosis) is a rare but fatal infection caused by fung... more Mucormycosis (previously referred to as zygomycosis) is a rare but fatal infection caused by fungal species of the order Mucorales, family Mucoraceae. It is usually seen in immunocompromised individuals, such as those suffering from diabetes, recipients of organ transplants or patients on chemotherapy. Depending on the site affected, the disease can be pulmonary, cutaneous, rhinocerebral, gastrointestinal or disseminated. We present the case of a 40-year old male who was a known chronic alcoholic and was admitted with haematemesis from oesophageal varices for which endoscopic banding was done. However, his condition continued to deteriorate. He subsequently succumbed and a gastric ulcer due to mucormycosis was found among other observations.
This study was performed to quantify the number of neutrophils and eosinophils in nasal secretion... more This study was performed to quantify the number of neutrophils and eosinophils in nasal secretions from paediatric patients with perennial rhinitis, under infected and non infected conditions, to differentiate infected bacterial from viral rhinitis and allergic from infected rhinitis. Nasal secretions and mucosal scrapings of 93 children up to 12 years with symptoms and signs of perennial rhinitis were subjected to cytological analysis. The smears were stained with H and E and 10 HPF’s were examined. Grading was done utilizing the semiquantitative nasal cytology grading score of Meltzer. 21 healthy children were used as controls. The material was also subjected to bacteriologic al analysis. Additional ancillary investigations done were a CBC and an absolute eosinophil count. There were distinctive differences in the grading scores between the cases of perennial rhinitis and the control groups, both were significantly higher in the former, we were able to differentiate between infect...
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