Background: Vulnerable patients from marginalized groups (e.g., people with disabilities, people ... more Background: Vulnerable patients from marginalized groups (e.g., people with disabilities, people experiencing homelessness, black and minority ethnic communities) experience higher rates of ill-health, inequitable access to healthcare and low engagement with screening services. Addressing these disparities and ensuring healthcare provision is impartial and fair is a priority for the United Kingdom (UK) healthcare system. Aim: Using Levesque’s access conceptual framework, this study explored the views of patients from marginalized groups, specifically on how access to pharmacy services could be improved and their experiences of receiving a medication review service. Method: Qualitative data were collected via semi-structured interviews on patient experiences of pharmacy services and how access to these could be improved (n = 10). Interviews of patients who had received a medication review from their pharmacist were also conducted (n = 10). Using an interpretivist approach, five ‘dema...
Objectives: Oxytocin is a nonapeptide hormone synthesised mostly by the neurons in the paraventri... more Objectives: Oxytocin is a nonapeptide hormone synthesised mostly by the neurons in the paraventricular and supraoptic nucleus of the hypothalamus; it is then released into the bloodstream by the posterior pituitary.1-3 (NB. It can also be synthesised in some peripheral tissues such as the uterus and placenta).1-3 The neuropeptide hormone, which is mainly involved in promoting maternal behaviour, has further also been widely studied as a potential for treatment of social deficit symptoms in many neurological disorders such as autism, personality disorders and schizophrenia.4 This meta-analysis was carried out to examine whether or not the following hypothesis was true: “oxytocin enhances emotion recognition in children and youths with ASD”. The aim was to see the impact of oxytocin administration (short-term) on social deficit symptoms in children suffering from ASD on a wider scale. In addition, the role of the neurohypophyseal hormone oxytocin in healthy individuals and adults with...
As global life expectancy increases, older people with chronic diseases are being required to man... more As global life expectancy increases, older people with chronic diseases are being required to manage multiple and complex medicine regimes. However, polypharmacy raises the risk of medicine-related problems and preventable hospital admissions. To improve medicine use, English community pharmacies are commissioned to deliver Medicines Use Reviews (MURs), which are typically delivered from the pharmacy. People who are homebound rarely receive the service. This paper describes the uptake and impact of a pilot project that seeks to provide domiciliary Medicines Use Reviews (dMURs). Participating pharmacists collected data on their dMUR activity over a 12-month period. Outcome measures (eg, adherence, side-effects, pharmacist assessment of preventable hospital admissions) were recorded. Pharmacists were also invited to submit written testimonies of their experiences of undertaking dMURs. Out of 433 possible pharmacies eligible to take part in the pilot, 186 pharmacies expressed an intere...
Introduction Increased mortality has been demonstrated in older adults with coronavirus disease 2... more Introduction Increased mortality has been demonstrated in older adults with coronavirus disease 2019 (COVID-19), but the effect of frailty has been unclear. Methods This multi-centre cohort study involved patients aged 18 years and older hospitalised with COVID-19, using routinely collected data. We used Cox regression analysis to assess the impact of age, frailty and delirium on the risk of inpatient mortality, adjusting for sex, illness severity, inflammation and co-morbidities. We used ordinal logistic regression analysis to assess the impact of age, Clinical Frailty Scale (CFS) and delirium on risk of increased care requirements on discharge, adjusting for the same variables. Results Data from 5,711 patients from 55 hospitals in 12 countries were included (median age 74, interquartile range [IQR] 54–83; 55.2% male). The risk of death increased independently with increasing age (>80 versus 18–49: hazard ratio [HR] 3.57, confidence interval [CI] 2.54–5.02), frailty (CFS 8 versu...
Background: Vulnerable patients from marginalized groups (e.g., people with disabilities, people ... more Background: Vulnerable patients from marginalized groups (e.g., people with disabilities, people experiencing homelessness, black and minority ethnic communities) experience higher rates of ill-health, inequitable access to healthcare and low engagement with screening services. Addressing these disparities and ensuring healthcare provision is impartial and fair is a priority for the United Kingdom (UK) healthcare system. Aim: Using Levesque’s access conceptual framework, this study explored the views of patients from marginalized groups, specifically on how access to pharmacy services could be improved and their experiences of receiving a medication review service. Method: Qualitative data were collected via semi-structured interviews on patient experiences of pharmacy services and how access to these could be improved (n = 10). Interviews of patients who had received a medication review from their pharmacist were also conducted (n = 10). Using an interpretivist approach, five ‘dema...
Objectives: Oxytocin is a nonapeptide hormone synthesised mostly by the neurons in the paraventri... more Objectives: Oxytocin is a nonapeptide hormone synthesised mostly by the neurons in the paraventricular and supraoptic nucleus of the hypothalamus; it is then released into the bloodstream by the posterior pituitary.1-3 (NB. It can also be synthesised in some peripheral tissues such as the uterus and placenta).1-3 The neuropeptide hormone, which is mainly involved in promoting maternal behaviour, has further also been widely studied as a potential for treatment of social deficit symptoms in many neurological disorders such as autism, personality disorders and schizophrenia.4 This meta-analysis was carried out to examine whether or not the following hypothesis was true: “oxytocin enhances emotion recognition in children and youths with ASD”. The aim was to see the impact of oxytocin administration (short-term) on social deficit symptoms in children suffering from ASD on a wider scale. In addition, the role of the neurohypophyseal hormone oxytocin in healthy individuals and adults with...
As global life expectancy increases, older people with chronic diseases are being required to man... more As global life expectancy increases, older people with chronic diseases are being required to manage multiple and complex medicine regimes. However, polypharmacy raises the risk of medicine-related problems and preventable hospital admissions. To improve medicine use, English community pharmacies are commissioned to deliver Medicines Use Reviews (MURs), which are typically delivered from the pharmacy. People who are homebound rarely receive the service. This paper describes the uptake and impact of a pilot project that seeks to provide domiciliary Medicines Use Reviews (dMURs). Participating pharmacists collected data on their dMUR activity over a 12-month period. Outcome measures (eg, adherence, side-effects, pharmacist assessment of preventable hospital admissions) were recorded. Pharmacists were also invited to submit written testimonies of their experiences of undertaking dMURs. Out of 433 possible pharmacies eligible to take part in the pilot, 186 pharmacies expressed an intere...
Introduction Increased mortality has been demonstrated in older adults with coronavirus disease 2... more Introduction Increased mortality has been demonstrated in older adults with coronavirus disease 2019 (COVID-19), but the effect of frailty has been unclear. Methods This multi-centre cohort study involved patients aged 18 years and older hospitalised with COVID-19, using routinely collected data. We used Cox regression analysis to assess the impact of age, frailty and delirium on the risk of inpatient mortality, adjusting for sex, illness severity, inflammation and co-morbidities. We used ordinal logistic regression analysis to assess the impact of age, Clinical Frailty Scale (CFS) and delirium on risk of increased care requirements on discharge, adjusting for the same variables. Results Data from 5,711 patients from 55 hospitals in 12 countries were included (median age 74, interquartile range [IQR] 54–83; 55.2% male). The risk of death increased independently with increasing age (>80 versus 18–49: hazard ratio [HR] 3.57, confidence interval [CI] 2.54–5.02), frailty (CFS 8 versu...
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