Abstract
The combination of classifiers has been proposed as a method to improve the accuracy achieved by a single classifier. In this study, the performances of optimistic and pessimistic ordered weighted averaging operators for protein secondary structure classifiers fusion have been investigated. Each secondary structure classifier outputs a unique structure for each input residue. We used confusion matrix of each secondary structure classifier as a general reusable pattern for converting this unique label to measurement level. The results of optimistic and pessimistic OWA operators have been compared with majority voting and five common classifiers used in the fusion process. Using a benchmark set from the EVA server, the results showed a significant improvement in the average Q3 prediction accuracy up to 1.69% toward the best classifier results.
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Argos, P., Hanei, M., Garavito, R.M.: The Chou-Fasman secondary structure prediction method with an extended database. FEBS Lett. 93(1), 19–24 (1978)
Cai, Y.D., Liu, X.J., Chou, K.C.: Prediction of protein secondary structure content by artificial neural network. J. Comput. Chem. 24(6), 727–731 (2003)
Kim, S.: Protein beta-turn prediction using nearest-neighbor method. Bioinformatics 20(1), 40–44 (2004)
Ho, T.H., Hull, J.J., Srihari, S.N.: Decision Combination in Multiple Classifier System. IEEE Transactions on Pattern Analysis and Machine Intelligence 16(1), 66–75 (1994)
Ruta, D., Gabrys, B.: An Overview of Classifier Fusion Methods. Computing and Information Systems 7, 1–10 (2000)
Xu, L., Krzyzak, A., Suen, C.Y.: Methods of Combining Multiple Classifiers and their Applications to Handwriting Recognition. IEEE Trans. SMC 22(3), 418–435 (1992)
Robles, V., Larranaga, P., Pena, J.M., Menasalvas, E., Perez, M.S., Herves, V., Wasilewska, A.: Bayesian network multi-classifiers for protein secondary structure prediction. Artif. Intell. Med. 31(2), 117–136 (2004)
Parker, J.R.: Rank and response combination from confusion matrix data. Information Fusion 2(2), 113–120 (2001)
Yager, R.R.: On ordered weighted averaging aggregation operators in multi-criteria decision making. IEEE transactions on Systems, Man and Cybernetics 18, 183–190 (1988)
Rost, B., Eyrich, V.A.: EVA: large-scale analysis of secondary structure prediction. Proteins 5, 192–199 (2001)
Raghava, G.P.S.: Protein secondary structure prediction using nearest neighbor and neural network approach. CASP 4, 75–76 (2000)
Rost, B.: PROF: predicting one-dimensional protein structure by profile based neural networks, http://cubic.bioc.columbia.edu/predictprotein
Jones, D.T.: Protein secondary structure prediction based on position-specific scoring matrices. J. Mol. Biol. 292, 195–202 (1999)
Karplus, K., Barrett, C., Hughey, R.: Hidden Markov Models for Detecting Remote Protein Homologies. Bioinformatics 14, 846–856 (1998)
Pollastri, G., Przybylski, D., Rost, B., Baldi, P.: Improving the Prediction of Protein Secondary Structure in Three and Eight Classes Using Recurrent Neural Networks and Profiles. Proteins 47, 228–235 (2002)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2005 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Kazemian, M., Moshiri, B., Nikbakht, H., Lucas, C. (2005). Protein Secondary Structure Classifiers Fusion Using OWA. In: Oliveira, J.L., Maojo, V., MartÃn-Sánchez, F., Pereira, A.S. (eds) Biological and Medical Data Analysis. ISBMDA 2005. Lecture Notes in Computer Science(), vol 3745. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11573067_34
Download citation
DOI: https://doi.org/10.1007/11573067_34
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-29674-4
Online ISBN: 978-3-540-31658-9
eBook Packages: Computer ScienceComputer Science (R0)