Abstract
Blood oxygenation level dependent (BOLD) contrast based functional magnetic resonance imaging (fMRI) has been widely utilized to detect brain neural activities and great efforts are now stressed on the hemodynamic processes of different brain regions activated by a stimulus. The focus of this paper is Gaussian dynamic convolution models of the fMRI BOLD response. The convolutions are between the perfusion function of the neural response to a stimulus and a Gaussian function. The parameters of the models are estimated by a nonlinear least-squares optimal algorithm for the fMRI data of eight subjects collected in a visual stimulus experiment. The results show that the Gaussian model is better in fitting the data.
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References
Kwong, K., Belliveau, J., Chesler, D.: Dynamic Magnetic Resonance Imaging of Human Brain Activity During Primary Sensory Stimulation. Proc. Natl. Acad. Sci. USA 89, 5675–5679 (1992)
Ogawa, S., Tank, D.W., Menon, R., Ellermann, J.M., Kim, S.G., Merkle, H., Ugurbil, K.: Intrinsic Signal Changes Accompanying Sensory Stimulation: Functional Brain Mapping with Magnetic Resonance Imaging. Proc. Natl. Acad. Sci. USA 89, 5951–5955 (1992)
Bandettini, P.A., Jesmanowicz, A., Wong, E.C., Hyde, J.S.: Processing Strategies for Time-Course Data Sets in Functional MRI of the Human Brain. Magnetic Resonance in Medicine 30(2), 161–173 (1993)
Rasmus, M.B., Ziad, S.S., Peter, A.N.: Spatial Heterogeneity of the Nonlinear Dynamics in the FMRI BOLD Response. NeuroImage 14(5), 817–826 (2001)
Yao, D.: Highresoltion EEG Mappings:A Spherical Harmonic Spectra Theory and Simulation Results.  Clinical Neurophysiology 111(1), 81–92 (2000)
Boynton, G.M., Engel, S.A., Glover, G.H., Heeger, D.J.: Linear Systems Analysis of Functional Magnetic Resonance Imaging in Human V1. J. of Neuroscience 16(13), 4207–4221 (1996)
Rao, S.M., Bandettini, P.A., Binder, J.R., Bobholz, J.A., Hammeke, T.A., Stein, v., Hyde, v.: Relationship Between Finger Movement Rate and Functional Magnetic Resonance Signal Change in Human Primary Motor Cortex. J. of Cerebral Blood Flow and Metabolis 16(6), 1250–1254 (1996)
Miller., V., Luh, W.M., Liu, T.T., Martinez, A., Obata, T., Wong, E.C., Frank, L.R., Buxton, R.B.: Nonlinear Temporal Dynamics of the Cerebral Blood Flow Response. Human Brain Mapping 13(1), 1–12 (2001)
Buxton, R.B., Liu, T.T., Wong, E.C.: Nonlinearity of the Hemodynamic Response: Modeling the Neural and BOLD Contributions. In: Proc. 9th ISMRM, vol. 1164 (2001)
Liu, H.L., Gao, J.H.: An investigation of the Impulse Functions for the Nonlinear BOLD Response in functional MRI. Magnetic Resonance Imaging 18(8), 931–938 (2000)
Vazquez, A.L., Noll, D.C.: Nonlinear Aspects of the BOLD Response in Functional MRI. Neuroimage 7(2), 108–118 (1998)
Aguirre, G.K., Zarahn, E., Esposito, M.D.: The Variability of Human BOLD Hemodynamic Responses. NeuroImage 8(4), 360–369 (1998)
Chen, H., Yao, D.: An Extended Gamma Dynamic Model of fMRI BOLD Response. Neurocomputing 61, 395–400 (2004)
Logothetis, N.K., Pauls, J., Augath, M., Trinath, T., Oeltermann, A.: Neurophysiological Investigation of the Basis of the FMRI Signal. Nature 412, 150–157 (2001)
Rajapakse, J.C., Kruggel, F., Maisog, J.M., VonCramon, D.Y.: Modelling Hemodynamic Response for Analysis of Functional MRI Time-series. Human Brain Mapping 6(4), 283–300 (1998)
Rosen, B.R., Buckner, R.L., Dale, A.: Event-related Functional MRI: Past, Present, and Future. Proc. Natl. Acad. Sci. USA 95, 773–780 (1998)
Chen, H., Yao, D., Liu, Z.: A Study on Asymmetry of Spatial Visual Field by Analysis of the FMRI BOLD Response. Brain topography 17(1), 39–46 (2004)
Chen, H., Yao, D., Zhuo, Y., Chen, L.: Analysis of FMRI Data by Blind Separation into Independent Temporal Component. Brain Topography 15(4), 223–232 (2003)
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Chen, H., Zeng, L., Yao, D., Gao, Q. (2006). A Gaussian Dynamic Convolution Models of the FMRI BOLD Response. In: Wang, J., Yi, Z., Zurada, J.M., Lu, BL., Yin, H. (eds) Advances in Neural Networks - ISNN 2006. ISNN 2006. Lecture Notes in Computer Science, vol 3971. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11759966_4
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DOI: https://doi.org/10.1007/11759966_4
Publisher Name: Springer, Berlin, Heidelberg
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