Abstract
Standard Mammogram Form (SMF), is a standardized, quantitative representation of a breast x-ray that can be easily estimated. From SMF it is possible to compute the volume of non-fat tissue and measures of breast density, both of which are of significant interest in determining breast cancer risk. Previous theoretical analysis of SMF suggested that a complete and substantial set of calibration data (such as mAs and kVp) would be needed to generate realistic breast composition measures, which is problematical since there have been many interesting trials that have retrospectively collected images with no calibration data. In this paper, we show how implementations of SMF include self-compensation mechanisms, so that SMF can be applied retrospectively to data for which calibration parameters are not (or only partially) available. To illustrate our findings, the current implementation of SMF (version 2.2β) was run over 4,028 digitized film-screen mammograms taken from 6 sites during the years 1988-2002, both with and without using the known calibration data. Results show that the SMF implementation running with no calibration data generates results which display a strong relationship with those obtained using a complete set of calibration data. More importantly, they bear a close relationship to an expert’s visual assessment of breast composition using established techniques.
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References
Boyd, N., Lockwood, G., Byng, J., Tritchler, D., Yaffe, M.: Mammographic densities and breast cancer risk. Cancer Epidemiol. Biomarkers Prev. 7, 1133–1144 (1998)
Burch, A., Law, J.: A method for estimating compressed breast thickness during mammography. British J. Radiology 68, 394–399 (1995)
Heine, J., Malhotra, P.: Mammographic tissue, breast cancer risk, serial image analysis, and digital mammography. Part 1: Tissue and related risk factors. Acad. Radiol. 9(3), 298–316 (2002)
Highnam, R., Brady, M.: Mammographic Image Analysis. Kluwer Academic Publishers, Dordrecht (1999)
Hufton, A., Astley, S., Marchant, T., Patel, H.: A method for the quantification of dense breast tissue from digitised mammograms. In: Proceedings of the IWDM 2004, vol. 2 (in press, 2004)
Jeffreys, M., Warren, R., Gunnell, D., McCarron, P., Highnam, R., Davey Smith, G.: Body Mass Index in young adulthood and breast cancer risk (abstract). Australasian Epidemiologist 2003 10(3), 17 (2003a)
Jeffreys, M., Warren, R., Highnam, R., Davey Smith, G.: Initial experience of using an automated volumetric measure of breast density: the standard mammogram form (SMF). British Journal of Radiology (in press, 2006)
Pawluczyk, O., Augustine, B.J., Yaffe, M.J., Rico, D., Yang, J., Mawdsley, G.E.: A volumetric method for estimation of breast density on digitized screen-film mammograms. Med. Phys. 2003 30(3), 352–364 (2003)
Tromans, C.: Measuring breast density from x-ray mammograms, DPhil. Thesis to be submitted March 2006, University of Oxford (2006)
Wolfe, J.N.: Breast patterns as an index of risk for developing breast cancer. Am. J. Roentgenol. 126(6), 1130–1137 (1976)
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© 2006 Springer-Verlag Berlin Heidelberg
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Highnam, R., Pan, XB., Warren, R., Jeffreys, M., Smith, G.D., Brady, M. (2006). Breast Composition Measurements Using Retrospective Standard Mammogram Form (SMF). In: Astley, S.M., Brady, M., Rose, C., Zwiggelaar, R. (eds) Digital Mammography. IWDM 2006. Lecture Notes in Computer Science, vol 4046. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11783237_34
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DOI: https://doi.org/10.1007/11783237_34
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-35625-7
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